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The map label for this gene is cbl [H]

Identifier: 157158758

GI number: 157158758

Start: 2237791

End: 2238741

Strand: Reverse

Name: cbl [H]

Synonym: EcE24377A_2269

Alternate gene names: 157158758

Gene position: 2238741-2237791 (Counterclockwise)

Preceding gene: 157158368

Following gene: 157158251

Centisome position: 44.96

GC content: 48.16

Gene sequence:

>951_bases
GTGAATTTCCAACAACTAAAGATAATCCGCGAGGCTGCACGTCAGGATTACAACCTGACAGAGGTTGCGAATATGCTTTT
TACCTCACAGTCAGGCGTCAGCCGTCATATTCGGGAACTGGAGGATGAACTTGGCATCGAAATATTTGTTCGACGAGGTA
AGCGACTGCTGGGCATGACTGAACCGGGCAAAGCATTACTGGTCATTGCAGAACGTATTCTGAATGAAGCCAGTAATGTT
CGTCGGCTTGCAGACCTGTTTACCAACGATACGTCTGGCGTTCTCACTATTGCAACGACGCATACTCAGGCACGTTATAG
CTTGCCAGAGGTCATTAAAGCTTTTCGCGAACTTTTCCCGGAGGTTCGGCTCGAGCTAATCCAGGGGACGCCACAGGAAA
TTGCGACATTGTTGCAAAATGGCGAAGCTGATATTGGTATCGCCAGCGAGCGTTTGAGTAATGACCCGCAGCTCGTCGCC
TTCCCGTGGTTTCGTTGGCACCATAGTTTGCTTGTTCCACACGATCATCCCTTGACGCAAATTTCACCATTGACGCTGGA
ATCAATAGCGAAGTGGCCGTTAATCACTTACCGACAGGGGATTACGGGGCGCTCACGTATTGATGACGCATTTGCCCGCA
AAGGTTTGCTGGCAGATATTGTATTAAGTGCGCAGGATTCTGATGTCATTAAAACCTATGTTGCTCTTGGGCTTGGGATC
GGATTAGTTGCCGAACAATCCAGCGGCGAACAAGAGGAAGAGAATTTAATCCGTCTGGATACGCGGCATCTTTTCGATGC
TAATACTGTCTGGTTGGGACTGAAGCGAGGACAACTTCAGCGTAACTATGTCTGGCGCTTTCTGGAACTTTGTAATGCAG
GACTGTCAGTTGAGGATATCAAGCGGCAGGTGATGGAAAACAGTGAAGAGGAAATTGATTATCAGATATAG

Upstream 100 bases:

>100_bases
TGTTATATCGGAATGGAATAAGATGCGGGTTTTTATTATTTGTTATGCCGGGCATTAGACTTTAACAATAACGGGAAATC
TGAACTGCCCGGAGTTTACC

Downstream 100 bases:

>100_bases
CAAAAAGCCCGCTATAAAAGCGGGCTTTTCAGAAATTTGGCTCCTCTGACTGGACTCGAACCAGTGACATACGGATTAAC
AGTCCGCCGTTCTACCGACT

Product: transcriptional regulator Cbl

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPHDHPLTQISPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Sequences:

>Translated_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPHDHPLTQISPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI
>Mature_316_residues
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMTEPGKALLVIAERILNEASNV
RRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFPEVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVA
FPWFRWHHSLLVPHDHPLTQISPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDIKRQVMENSEEEIDYQI

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=316, Percent_Identity=99.6835443037975, Blast_Score=641, Evalue=0.0,
Organism=Escherichia coli, GI1787530, Length=313, Percent_Identity=41.2140575079872, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI1788481, Length=293, Percent_Identity=27.3037542662116, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=28.9855072463768, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790208, Length=249, Percent_Identity=28.5140562248996, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788887, Length=235, Percent_Identity=28.0851063829787, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367136, Length=245, Percent_Identity=24.8979591836735, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693105, Length=232, Percent_Identity=25, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87081904, Length=208, Percent_Identity=29.3269230769231, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082132, Length=134, Percent_Identity=35.0746268656716, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35883; Mature: 35883

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPHDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEECCCCCCCCC
ISPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
CCCCCHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC
>Mature Secondary Structure
MNFQQLKIIREAARQDYNLTEVANMLFTSQSGVSRHIRELEDELGIEIFVRRGKRLLGMT
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHCCCHHCCCC
EPGKALLVIAERILNEASNVRRLADLFTNDTSGVLTIATTHTQARYSLPEVIKAFRELFP
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHHHHHHHHH
EVRLELIQGTPQEIATLLQNGEADIGIASERLSNDPQLVAFPWFRWHHSLLVPHDHPLTQ
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCEEEECHHHHCCCEECCCCCCCCC
ISPLTLESIAKWPLITYRQGITGRSRIDDAFARKGLLADIVLSAQDSDVIKTYVALGLGI
CCCCCHHHHHCCCCHHHHCCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHH
GLVAEQSSGEQEEENLIRLDTRHLFDANTVWLGLKRGQLQRNYVWRFLELCNAGLSVEDI
HEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
KRQVMENSEEEIDYQI
HHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]