Click here to switch to the map view.

The map label for this gene is cobT [H]

Identifier: 157157289

GI number: 157157289

Start: 2241215

End: 2242294

Strand: Reverse

Name: cobT [H]

Synonym: EcE24377A_2273

Alternate gene names: 157157289

Gene position: 2242294-2241215 (Counterclockwise)

Preceding gene: 157157942

Following gene: 157155230

Centisome position: 45.03

GC content: 52.41

Gene sequence:

>1080_bases
ATGCAAACACTTGCCGATTTACTGAATACGATCCCTGCCATCGATCCTGCCGCGATGTCGCGTGCACAACGGCATATTGA
CGGGTTACTCAAACCTGTTGGTAGCCTGGGAAGGCTGGAGGCGCTTGCCATACAACTGGCAGGAATGCCGGGGTTGAATG
GCATACCGCATGTGGGCAAAAAAGCGGTACTGGTTATGTGTGCCGATCACGGCGTCTGGGAGGAAGGGGTCGCTATTTCC
CCAAAAGAAGTGACAGCCATTCAGGCTGAAAATATGACCCGCGGAACAACCGGCGTGTGTGTGCTGGCAGCACAAGCGGG
CGCTAACGTCTACGTAATTGATGTTGGTATTGATACTGCTGAGCCTATCCCCGGGCTTATCAACATGCGTGTTGCTCGAG
GTAGTGGCAATATTGCTTCAGCTCCGGCAATGAGTCGCCATCAGGCAGAAAAGTTGCTTTTGGACGTCATATGTTATACG
CGGGAGCTGGCAAAAAACGGTGTTACGCTGTTTGGTGTAGGTGAACTGGGGATGGCAAACACGACACCGGCAGCGGCAAT
AGTCAGCACAATCACTGGCCGGGCTCCTGAAGAAGTGGTTGGGATTGGCGCAAACCTGCCGACAGATAAACTGGCTAATA
AAATTGATGTTGTGCGCCGGGCGATTACGTTGAATCAACCAAATCCGCAGGATGGCGTTGATGTCCTGGCAAAAGTGGGT
GGATTTGATTTGGTCGGAATGGCTGGCGTGATGTTAGGCGCTGCTTCCTGCGGTTTACCCGTGTTGCTGGATGGATTTCT
TTCTTATGCTGCCGCGCTCGCAGCCTGCCAGATGTCTCCTGCAATCAAACCGTATCTCATTCCTTCTCACCTGTCGGCAG
AAAAAGGGGCGCGTATTGCGCTGTCGCATTTGGGGCTGGAGCCTTATCTCAATATGGAGATGCGTTTAGGTGAGGGGAGT
GGCGCAGCTCTGGCGATGCCCATCATCGAAGCTGCCTGTGCGATATATAACAACATGGGCGAACTTGCTGCCAGTAATAT
TGTTCTACCGGGGAATACGACTTCTGATTTGAACAGTTAA

Upstream 100 bases:

>100_bases
TCAAACGTACGCTGGGCGGGCAAACCGGCGATACGCTGGGAGCTGCTATAGAGCTTGGTGAACTGGTCTTCCTGCTGGCA
CTGCTATAAAGAGACGTGAC

Downstream 100 bases:

>100_bases
AAACGAAAAGTCTGATAAAAGCTATACTTAACGGATAGCTTTCGCGACTTAGGAAAGGGACATGATGCGTCGTGTAAATA
TTTTTTGCTCATTTGCTCTG

Product: nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALAIQLAGMPGLNGIPHVGKKAVLVMCADHGVWEEGVAIS
PKEVTAIQAENMTRGTTGVCVLAAQAGANVYVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRHQAEKLLLDVICYT
RELAKNGVTLFGVGELGMANTTPAAAIVSTITGRAPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVG
GFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPYLNMEMRLGEGS
GAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS

Sequences:

>Translated_359_residues
MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALAIQLAGMPGLNGIPHVGKKAVLVMCADHGVWEEGVAIS
PKEVTAIQAENMTRGTTGVCVLAAQAGANVYVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRHQAEKLLLDVICYT
RELAKNGVTLFGVGELGMANTTPAAAIVSTITGRAPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVG
GFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPYLNMEMRLGEGS
GAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
>Mature_359_residues
MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALAIQLAGMPGLNGIPHVGKKAVLVMCADHGVWEEGVAIS
PKEVTAIQAENMTRGTTGVCVLAAQAGANVYVIDVGIDTAEPIPGLINMRVARGSGNIASAPAMSRHQAEKLLLDVICYT
RELAKNGVTLFGVGELGMANTTPAAAIVSTITGRAPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVG
GFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIALSHLGLEPYLNMEMRLGEGS
GAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) [H]

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family [H]

Homologues:

Organism=Escherichia coli, GI1788300, Length=359, Percent_Identity=96.9359331476323, Blast_Score=695, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846 [H]

Pfam domain/function: PF02277 DBI_PRT [H]

EC number: =2.4.2.21 [H]

Molecular weight: Translated: 36906; Mature: 36906

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALAIQLAGMPGLNGIPHVGK
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCCCCCC
KAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAAQAGANVYVIDVGIDTA
CEEEEEEECCCCCCCCCEECCHHEEEEECCCCCCCCCCEEEEEEECCCEEEEEEECCCCC
EPIPGLINMRVARGSGNIASAPAMSRHQAEKLLLDVICYTRELAKNGVTLFGVGELGMAN
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
TTPAAAIVSTITGRAPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVG
CCHHHHHHHHHCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIA
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEE
LSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
HHHCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCC
>Mature Secondary Structure
MQTLADLLNTIPAIDPAAMSRAQRHIDGLLKPVGSLGRLEALAIQLAGMPGLNGIPHVGK
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHEECCCCCCCCCCCCCC
KAVLVMCADHGVWEEGVAISPKEVTAIQAENMTRGTTGVCVLAAQAGANVYVIDVGIDTA
CEEEEEEECCCCCCCCCEECCHHEEEEECCCCCCCCCCEEEEEEECCCEEEEEEECCCCC
EPIPGLINMRVARGSGNIASAPAMSRHQAEKLLLDVICYTRELAKNGVTLFGVGELGMAN
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
TTPAAAIVSTITGRAPEEVVGIGANLPTDKLANKIDVVRRAITLNQPNPQDGVDVLAKVG
CCHHHHHHHHHCCCCCHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHC
GFDLVGMAGVMLGAASCGLPVLLDGFLSYAAALAACQMSPAIKPYLIPSHLSAEKGARIA
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCEEE
LSHLGLEPYLNMEMRLGEGSGAALAMPIIEAACAIYNNMGELAASNIVLPGNTTSDLNS
HHHCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA