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The map label for this gene is tcaB [H]

Identifier: 156980670

GI number: 156980670

Start: 2481248

End: 2482456

Strand: Reverse

Name: tcaB [H]

Synonym: SAHV_2339

Alternate gene names: 156980670

Gene position: 2482456-2481248 (Counterclockwise)

Preceding gene: 156980671

Following gene: 156980668

Centisome position: 86.19

GC content: 33.5

Gene sequence:

>1209_bases
ATGAATGATTTAACGCATTTTAACAAGCGTTCACCGATATTTATTATTATTTTAGGATCTTTGACGGCCATTGGAGCATT
ATCGATAGATATGTTTTTGCCTGGATTACCAGATATTAGACATGATTTTCAAACAACGACGTCTAACGCACAATTAACAT
TATCGATGTTTATGATTGGTTTAGCGTTTGGTAATTTGTTTGCTGGTCCAATTTCAGATTCAACTGGGCGCAGAAAGCCG
CTTATTATAGCTATGATTATTTTTACATTAGCAAGTTTAGGTATTGTTTTTGTACATAATATTTGGCTGATGGTTGCATT
AAGATTTCTTCAAGGAGTGACAGGTGGCGCAGCAGCAGTTATTTCAAGAGCTATAGCAAGTGATATGTATAGTGGTAATG
AACTAACTAAGTTTATGGCATTATTGATGCTTGTTAATGGTATTGCACCAGTTGTTGCGCCAACAATAGGGGGCATAATT
TTAAATTATTCTGTCTGGCGTATGGTCTTTGTCATTCTGACTATCTTTGGTTTCGTCATGGTCATAGGTTCTTTATTAAA
AGTACCTGAATCATTAACAGTGACAAATCGTGAGTCAAGTAGTGGATTAAAAACAATGTTTAAAAACTTCAAAATATTAT
TGAAGACGCCACGTTTTGTATTACCAATGCTCATTCAAGGTATGACATTTGTAATATTATTTACTTATATTTCTGCGTCT
CCGTTTATTATTCAAAAAATTTATGGCATGACTGCAATACAATTTAGTTGGATGTTTGCAGGAATTGGTATTACGCTCAT
TATATCAAGTCAACTTACTGGGTACCTTGTTGATTTTATAGACTCACAAAAATTGATGAGAGGCATGACGATGATTCAGA
TTATCGGTGTAATTTTAGTGACGATTGTATTGCTTAATCATTGGAACTTTTGGATTTTAGCGATAGGATTTATCATTTTA
ATAGCACCAGTGACAGGTGTTGCGACACTTGGTTTTACAATAGCTATGGATGAAAGTAGTAGTGGTAGAGGGAGTTCATC
AAGTTTATTAGGTTTAGTGCAGTTTTTATTTGGTGGTGTTGCATCGCCATTAGTGGGGGTAAAAGGTGAAGATAATCCTA
TACCTTACATAATTATTATTATAGCTACAGCAGTTATATTAATTATTTTACAGATTTATAATATGAAGGTATTTAAAACA
AATCGATGA

Upstream 100 bases:

>100_bases
TGAAACTTGTGAGTAATGCTAATATATAAAAGAGCATATTTAAATTTAGTTTCTGTTCGTGATAGTTATAAACTAATCAT
TATATAAAGGAGATAGTCAT

Downstream 100 bases:

>100_bases
TAAACATAGTTTCTTCTATTATATTGAATTGAAAAATTAAAAAACAAAACTTGAGCTATTCATAGACCTATGAATTTAGC
ATCAAAAATAAAAATGCCGA

Product: TcaB protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MNDLTHFNKRSPIFIIILGSLTAIGALSIDMFLPGLPDIRHDFQTTTSNAQLTLSMFMIGLAFGNLFAGPISDSTGRRKP
LIIAMIIFTLASLGIVFVHNIWLMVALRFLQGVTGGAAAVISRAIASDMYSGNELTKFMALLMLVNGIAPVVAPTIGGII
LNYSVWRMVFVILTIFGFVMVIGSLLKVPESLTVTNRESSSGLKTMFKNFKILLKTPRFVLPMLIQGMTFVILFTYISAS
PFIIQKIYGMTAIQFSWMFAGIGITLIISSQLTGYLVDFIDSQKLMRGMTMIQIIGVILVTIVLLNHWNFWILAIGFIIL
IAPVTGVATLGFTIAMDESSSGRGSSSSLLGLVQFLFGGVASPLVGVKGEDNPIPYIIIIIATAVILIILQIYNMKVFKT
NR

Sequences:

>Translated_402_residues
MNDLTHFNKRSPIFIIILGSLTAIGALSIDMFLPGLPDIRHDFQTTTSNAQLTLSMFMIGLAFGNLFAGPISDSTGRRKP
LIIAMIIFTLASLGIVFVHNIWLMVALRFLQGVTGGAAAVISRAIASDMYSGNELTKFMALLMLVNGIAPVVAPTIGGII
LNYSVWRMVFVILTIFGFVMVIGSLLKVPESLTVTNRESSSGLKTMFKNFKILLKTPRFVLPMLIQGMTFVILFTYISAS
PFIIQKIYGMTAIQFSWMFAGIGITLIISSQLTGYLVDFIDSQKLMRGMTMIQIIGVILVTIVLLNHWNFWILAIGFIIL
IAPVTGVATLGFTIAMDESSSGRGSSSSLLGLVQFLFGGVASPLVGVKGEDNPIPYIIIIIATAVILIILQIYNMKVFKT
NR
>Mature_402_residues
MNDLTHFNKRSPIFIIILGSLTAIGALSIDMFLPGLPDIRHDFQTTTSNAQLTLSMFMIGLAFGNLFAGPISDSTGRRKP
LIIAMIIFTLASLGIVFVHNIWLMVALRFLQGVTGGAAAVISRAIASDMYSGNELTKFMALLMLVNGIAPVVAPTIGGII
LNYSVWRMVFVILTIFGFVMVIGSLLKVPESLTVTNRESSSGLKTMFKNFKILLKTPRFVLPMLIQGMTFVILFTYISAS
PFIIQKIYGMTAIQFSWMFAGIGITLIISSQLTGYLVDFIDSQKLMRGMTMIQIIGVILVTIVLLNHWNFWILAIGFIIL
IAPVTGVATLGFTIAMDESSSGRGSSSSLLGLVQFLFGGVASPLVGVKGEDNPIPYIIIIIATAVILIILQIYNMKVFKT
NR

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=378, Percent_Identity=29.6296296296296, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI48994889, Length=234, Percent_Identity=32.4786324786325, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790794, Length=289, Percent_Identity=23.5294117647059, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1790146, Length=243, Percent_Identity=27.5720164609054, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787065, Length=215, Percent_Identity=27.4418604651163, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082312, Length=187, Percent_Identity=26.2032085561497, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787880, Length=347, Percent_Identity=25.0720461095101, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319480, Length=294, Percent_Identity=19.7278911564626, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43824; Mature: 43824

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDLTHFNKRSPIFIIILGSLTAIGALSIDMFLPGLPDIRHDFQTTTSNAQLTLSMFMIG
CCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHH
LAFGNLFAGPISDSTGRRKPLIIAMIIFTLASLGIVFVHNIWLMVALRFLQGVTGGAAAV
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ISRAIASDMYSGNELTKFMALLMLVNGIAPVVAPTIGGIILNYSVWRMVFVILTIFGFVM
HHHHHHHHHCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGSLLKVPESLTVTNRESSSGLKTMFKNFKILLKTPRFVLPMLIQGMTFVILFTYISAS
HHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCC
PFIIQKIYGMTAIQFSWMFAGIGITLIISSQLTGYLVDFIDSQKLMRGMTMIQIIGVILV
HHHHHHHHCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIVLLNHWNFWILAIGFIILIAPVTGVATLGFTIAMDESSSGRGSSSSLLGLVQFLFGGV
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHCCH
ASPLVGVKGEDNPIPYIIIIIATAVILIILQIYNMKVFKTNR
HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCC
>Mature Secondary Structure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HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]