Click here to switch to the map view.

The map label for this gene is hutU [H]

Identifier: 156980646

GI number: 156980646

Start: 2457519

End: 2459180

Strand: Reverse

Name: hutU [H]

Synonym: SAHV_2315

Alternate gene names: 156980646

Gene position: 2459180-2457519 (Counterclockwise)

Preceding gene: 156980649

Following gene: 156980645

Centisome position: 85.38

GC content: 39.41

Gene sequence:

>1662_bases
ATGAGAAAAATTCAAGCAAAAAAAGGTTTGAGTATTGAGTGTAAAGGTTGGGAACAAGAAGCAGTACTTAGAATGTTATA
CAACAATTTAGACCCAGAAGTTGCTGAAAGACCAGAAGATTTAGTTGTTTATGGTGGTATTGGAAAAGCAGCACGTAATT
GGGAAGCTTTTGAAGCAATAGAGAAAACGTTACGAGAATTAGAATCAGATGAGACAATGTTAGTACAATCAGGAAAGCCA
GTTGCTGTATTTAAAACACATGAAGAAGCGCCACGTGTATTAATTTCAAATTCAGTATTAGTGCCTGAATGGGCAAACTG
GGATCATTTTAATGAATTAGATAAAAAAGGTTTAATCATGTATGGACAGATGACAGCCGGTAGTTGGATATATATTGGTT
CTCAAGGTATTGTGCAAGGTACTTATGAGACATTTGCCGAGCTAGGTAATCAACACTTTAATGGAGATTTAGCAGGCACT
GTTACACTGACAGCAGGTTTAGGTGGTATGGGTGGTGCGCAACCGTTAGCAATTACTATGAATCATGGGGTAGCAATTTG
CGTGGATGTTGATGAAACACGTGTTGATAAGCGAATTGATACGAAATACTGTGATGTTAAAACAGCTGATTTAGATGAAG
CATTAAAATTAGCAGAAGAGGCGAAAGAACGTGGAGAAGGATTATCAATCGGGTTAGTTGGAAATGCTGTAGACATCCAT
CAAGCGATTCTAGAAAAAGGATTTAAAATTGACATTATTACTGACCAAACAAGTGCACATGATCCGCTAAATGGATATGT
GCCACAAGGATACTCTGTAGAAGAAGCGAAAGTATTGCGTGAAAAAGATCCGAAAAAATATGTTGAACTGTCACAAGCTT
CAATGGCAAAGCATGTTGAATTAATGCTTGAATTCCAAAAACGTGGCGCTGTAGCATTTGATTATGGTAACAATATTCGT
CAAGTAGCCTTCAATAACGGAGTGAAAAATGCTTTTGACTTCCCAGGCTTTGTACCAGCTTACATTAGACCATTATTCTG
TGAAGGTAAAGGGCAATTCCGCTTTGCTGCGTTGAGTGGTGATCCAAAAGATATCGAGCGTGCGGATGAAGAAATGCGCA
AACTTTTCCCAGAAAATGAAAAGTTATTAAGATGGCTTGATTTAGCTGAAGAAAAAATTTCATATCAAGGACTACCATCA
CGTATTGCTTGGTTAGGCTATGGAGAAAGAGCGAAAATGGGCTTAGCTTTAAATCGTCTTGTACGTGACGGTGAAATTTC
AGCACCAATTGTTATTGGACGAGACCATTTAGATGCTGGTTCAGTTGCTAGTCCTAACCGTGAAACAGAAAGTATGAAAG
ATGGCAGTGACGCGGTTGGTGATTGGGCTGTATTGAATGCACTCATTAACACAGCTGCAGGTGGTTCATGGATTTCATTC
CATCACGGTGGCGGTGTTGGCATGGGATATTCACTTCATGCGGGTATGGTTGTTGTAGCAGATGGATCAGAGCGTGCTGA
AAGAAGATTGGAACGTGTATTGACGACTGATCCAGGTATGGGTGTTGCCCGACATGTTGATGCTGGCTATGACATCGCTA
TTCAAACAGCTAAAGAAAAAGGTATTCATATTCCAATGATTGATAAAGCAGGTGATAAATAA

Upstream 100 bases:

>100_bases
TTGGCTATATTTTAACATACTATAATGAATATTGAAGATAATAATGTAAGCGTTTTAAATTTAGTGGAATTAACTTCTTA
AAAGAACAGGAGCGAATTTT

Downstream 100 bases:

>100_bases
TGAATGATTTAATAATTAATCACATAGCAGAATTAATTTTACCGAAATCAACAGATAAACCTTTGAAGGGTAAGGAATTA
GATGAATTAAATGTTGTGAA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGQFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK

Sequences:

>Translated_553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGQFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK
>Mature_553_residues
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAIEKTLRELESDETMLVQSGKP
VAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIMYGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGT
VTLTAGLGGMGGAQPLAITMNHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVELMLEFQKRGAVAFDYGNNIR
QVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGQFRFAALSGDPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPS
RIAWLGYGERAKMGLALNRLVRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEKGIHIPMIDKAGDK

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=559, Percent_Identity=33.2737030411449, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI260306182, Length=619, Percent_Identity=30.6946688206785, Blast_Score=283, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI71997891, Length=550, Percent_Identity=33.4545454545455, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60665; Mature: 60665

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHCCHHHHHHH
EKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIM
HHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCCCHHHHHCCCCEEE
YGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITM
EEEECCCCEEEECCCCCEECHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEE
NHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
CCCEEEEEECCHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVE
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGQFRFAALSG
HHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEEECC
DPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRL
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
VRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEK
ECCCCCCCCEEECCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEHHHC
GIHIPMIDKAGDK
CCEEEECCCCCCC
>Mature Secondary Structure
MRKIQAKKGLSIECKGWEQEAVLRMLYNNLDPEVAERPEDLVVYGGIGKAARNWEAFEAI
CCCCCCCCCCEEEECCCCHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHCCHHHHHHH
EKTLRELESDETMLVQSGKPVAVFKTHEEAPRVLISNSVLVPEWANWDHFNELDKKGLIM
HHHHHHHCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCCCHHHHHCCCCEEE
YGQMTAGSWIYIGSQGIVQGTYETFAELGNQHFNGDLAGTVTLTAGLGGMGGAQPLAITM
EEEECCCCEEEECCCCCEECHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCEEEEE
NHGVAICVDVDETRVDKRIDTKYCDVKTADLDEALKLAEEAKERGEGLSIGLVGNAVDIH
CCCEEEEEECCHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
QAILEKGFKIDIITDQTSAHDPLNGYVPQGYSVEEAKVLREKDPKKYVELSQASMAKHVE
HHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LMLEFQKRGAVAFDYGNNIRQVAFNNGVKNAFDFPGFVPAYIRPLFCEGKGQFRFAALSG
HHHHHHHCCCEEEECCCCEEEEEECCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEEECC
DPKDIERADEEMRKLFPENEKLLRWLDLAEEKISYQGLPSRIAWLGYGERAKMGLALNRL
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHH
VRDGEISAPIVIGRDHLDAGSVASPNRETESMKDGSDAVGDWAVLNALINTAAGGSWISF
HCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
HHGGGVGMGYSLHAGMVVVADGSERAERRLERVLTTDPGMGVARHVDAGYDIAIQTAKEK
ECCCCCCCCEEECCCEEEEECCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEHHHC
GIHIPMIDKAGDK
CCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA