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The map label for this gene is fpoH [H]

Identifier: 156937932

GI number: 156937932

Start: 1022011

End: 1023078

Strand: Direct

Name: fpoH [H]

Synonym: Igni_1144

Alternate gene names: 156937932

Gene position: 1022011-1023078 (Clockwise)

Preceding gene: 156937930

Following gene: 156937933

Centisome position: 78.77

GC content: 58.61

Gene sequence:

>1068_bases
ATGATCGGCGGCGAGCTCCTAATCATAATAGCGCTCGTCTCCGTGCTCTTGGCTTTCGGCTACGCCGGGCTGCTGGACTT
GGTAACAATCTACATGGAGAGGAAGATGTGGGGTAAGATAATGCAGAGGTACGGGCCGACCCACGTGGGCTACGCGGGGC
TGTTGCAGCTCATAGCTGACTTCTTGAAGTACTTGTCCAAAGAGCTGTTCGCCCCCAGGAGGCCCAACAAGCTCTTCTAC
TACGGCCTGCCGCTGCTGCTGATAGCCATAATATCCATACCGTTAGTGTTGATCCCGCTGGACTACGTGGCCCTCTCCGG
CTTGGAGGGGCTGCTCAAGCTCGCCGGAATAAACGTTAACTTGAGCGACTACGCAGCCTCCAAGCTTTTGGACGAGCTGG
CCCCCGGCGTGGGGCTCTTGGGCTACGTCGCGGTAGTGGCAGTAACCATGCCGTTGATGTACATGCTCTCCTGGAACCAA
GCGAACAAGTACGGCGCCTTGGGCGCTTTCAGGACGGTGTTGCTACTCGTAACTTACGAGGTCCCCTTCCTGATAGCCAT
AGCCGCCGTGGCCGCCCTAGGGGGGCTGAGCTTCTACGGGGTGGTGGACTTCCAGAAGTCCGCTTGGCTGGCGCTGCTCA
ACCCCATAGCGGCCCTAGTGCTGTTCATAACTCTCCTCGCGGAGAGCGAGAGGCCCCCCTTCGACCACCCGGAGGCGGAG
CAAGAGATAGTGCACGGCTGGAACGTGGAGTACGGGGCGGGCGAGTTCATACTCCTTTACGGTTTATACTTGTACACTAA
GGCCCTCTACGCGGACGCGCTGATCACGCTGTTCTTGCTCGGGGGGTGGCTGGGCCCGGCGTTGCCGGGGCTGCCGGTCG
AGCTGACTAACGCCATATGGTTTACGGTAAAGATGGTTGCGGTGTTCGCGCTGTTCATACTGGTAAGGGCGGCCCTCGCG
AGGCCCAGGGTGGATCAGATACTCGAACTGGGCTGGACCAAGATACTGGCCTTATCGATAGTAGCCCTTTTCATATCCCT
TATTGTAAAGAGCGTCTGGCTCGCGTGA

Upstream 100 bases:

>100_bases
AGCCCCTCGCTCCTGCTCAAAGCCGCGTACCCAGCGGGCCCCCTCTTCGGCGTTAACAAAGATAATCTAATTCCGCGCTC
TCGAGCTAGGGCCACAGTCG

Downstream 100 bases:

>100_bases
GGTGAAACCCTTGGAGGAGAGGAGGTTCGTAGAGGTTAGGGAAAGGTGGGGTAGGAAGACCAACGCCCTCGGAGTTTTGA
AGTCCTTGAAGGCCGTTGCC

Product: NADH dehydrogenase (quinone)

Products: NAD+; ubiquinol

Alternate protein names: F(420)H(2) dehydrogenase subunit H; FPO subunit H [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MIGGELLIIIALVSVLLAFGYAGLLDLVTIYMERKMWGKIMQRYGPTHVGYAGLLQLIADFLKYLSKELFAPRRPNKLFY
YGLPLLLIAIISIPLVLIPLDYVALSGLEGLLKLAGINVNLSDYAASKLLDELAPGVGLLGYVAVVAVTMPLMYMLSWNQ
ANKYGALGAFRTVLLLVTYEVPFLIAIAAVAALGGLSFYGVVDFQKSAWLALLNPIAALVLFITLLAESERPPFDHPEAE
QEIVHGWNVEYGAGEFILLYGLYLYTKALYADALITLFLLGGWLGPALPGLPVELTNAIWFTVKMVAVFALFILVRAALA
RPRVDQILELGWTKILALSIVALFISLIVKSVWLA

Sequences:

>Translated_355_residues
MIGGELLIIIALVSVLLAFGYAGLLDLVTIYMERKMWGKIMQRYGPTHVGYAGLLQLIADFLKYLSKELFAPRRPNKLFY
YGLPLLLIAIISIPLVLIPLDYVALSGLEGLLKLAGINVNLSDYAASKLLDELAPGVGLLGYVAVVAVTMPLMYMLSWNQ
ANKYGALGAFRTVLLLVTYEVPFLIAIAAVAALGGLSFYGVVDFQKSAWLALLNPIAALVLFITLLAESERPPFDHPEAE
QEIVHGWNVEYGAGEFILLYGLYLYTKALYADALITLFLLGGWLGPALPGLPVELTNAIWFTVKMVAVFALFILVRAALA
RPRVDQILELGWTKILALSIVALFISLIVKSVWLA
>Mature_355_residues
MIGGELLIIIALVSVLLAFGYAGLLDLVTIYMERKMWGKIMQRYGPTHVGYAGLLQLIADFLKYLSKELFAPRRPNKLFY
YGLPLLLIAIISIPLVLIPLDYVALSGLEGLLKLAGINVNLSDYAASKLLDELAPGVGLLGYVAVVAVTMPLMYMLSWNQ
ANKYGALGAFRTVLLLVTYEVPFLIAIAAVAALGGLSFYGVVDFQKSAWLALLNPIAALVLFITLLAESERPPFDHPEAE
QEIVHGWNVEYGAGEFILLYGLYLYTKALYADALITLFLLGGWLGPALPGLPVELTNAIWFTVKMVAVFALFILVRAALA
RPRVDQILELGWTKILALSIVALFISLIVKSVWLA

Specific function: FPO shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to quinones in the F(420)H(2):heterodisulfide oxidoreduction chain. The immediate electron acceptor for the enzyme in this species is believed to be methanophenazine. Couples

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=312, Percent_Identity=29.1666666666667, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI1788618, Length=319, Percent_Identity=29.153605015674, Blast_Score=141, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023021
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: 1.6.5.3

Molecular weight: Translated: 38862; Mature: 38862

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGGELLIIIALVSVLLAFGYAGLLDLVTIYMERKMWGKIMQRYGPTHVGYAGLLQLIAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FLKYLSKELFAPRRPNKLFYYGLPLLLIAIISIPLVLIPLDYVALSGLEGLLKLAGINVN
HHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSDYAASKLLDELAPGVGLLGYVAVVAVTMPLMYMLSWNQANKYGALGAFRTVLLLVTYE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VPFLIAIAAVAALGGLSFYGVVDFQKSAWLALLNPIAALVLFITLLAESERPPFDHPEAE
HHHHHHHHHHHHHHCCHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
QEIVHGWNVEYGAGEFILLYGLYLYTKALYADALITLFLLGGWLGPALPGLPVELTNAIW
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FTVKMVAVFALFILVRAALARPRVDQILELGWTKILALSIVALFISLIVKSVWLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGGELLIIIALVSVLLAFGYAGLLDLVTIYMERKMWGKIMQRYGPTHVGYAGLLQLIAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FLKYLSKELFAPRRPNKLFYYGLPLLLIAIISIPLVLIPLDYVALSGLEGLLKLAGINVN
HHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSDYAASKLLDELAPGVGLLGYVAVVAVTMPLMYMLSWNQANKYGALGAFRTVLLLVTYE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
VPFLIAIAAVAALGGLSFYGVVDFQKSAWLALLNPIAALVLFITLLAESERPPFDHPEAE
HHHHHHHHHHHHHHCCHHHEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
QEIVHGWNVEYGAGEFILLYGLYLYTKALYADALITLFLLGGWLGPALPGLPVELTNAIW
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FTVKMVAVFALFILVRAALARPRVDQILELGWTKILALSIVALFISLIVKSVWLA
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]