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The map label for this gene is thrC [H]

Identifier: 156937824

GI number: 156937824

Start: 922896

End: 924122

Strand: Direct

Name: thrC [H]

Synonym: Igni_1034

Alternate gene names: 156937824

Gene position: 922896-924122 (Clockwise)

Preceding gene: 156937822

Following gene: 156937825

Centisome position: 71.13

GC content: 63.16

Gene sequence:

>1227_bases
GTGCGGGCCAAGCTTCGCTGCGTCCGGTGCGGGGCCGAGTACGACGTACAGCCCAAGATGTTCTCGTGCCCCAAGTGCGG
GGGCTTGCTGGAGGTGGTAATAGAGCCGGAGGAGCTGCCCCCCTTCTCTGAGTTCACCAAGAGGAGCAGGATGAAGGGGA
TATGGCGGTTCGCGGAGCTCCTCCCGGTCAAGAGCGGTTCCCCAGTAACGATGGGCGAGGGCAATACCCCCCTCATAAGG
TTGGAGAAGCTGGAGAAGGTGATAGGCGTAAGGAGGCTGTACGCGAAGTTCGAAGGGGCCAACCCTACGGGCTCCTTTAA
GGACAGGGGCATGAGCCTGGCGGTGACCGTAGCCAAGGAGGTTAAGGCCAGAGCGGTTGTGGCAGCCTCCACTGGCAACA
CGGCTGCTTCCGCTGCCGCCTACTCGGCCAGGGCGGGGCTCAAGACGTTCTTGATACTCCCGAGCGGCAAGGTGGCCTTG
GGCAAGCTGGCCCAGAGCTTGTTGCACGGGGCGGTGGTGGTCGAGCTGGAGGGGAACTTCGACGCGGCCTTGGAGGCGGT
CAAGGAGCTGGCCAAGATGCCGGAGTTTTACCCGTTGAACTCCTTCAACCCTTGGAGGCTCGAGGGTCAGAAGACCTTGG
CCTTCGAGCTGTTCGAAGAAATAGGGGTCCCGGACGTGGTCGTGGTGCCCGTGGGCAACGCGGGCAACATATCCGCCATA
TGGAAGGGATTCAAGGAGTTGAAGGAGTTCGGCTACTCCGAGGCCTTGCCCAAGATGGTCGGGGTCCAAGCGGAGGGGGC
CTCGCCCATAGCCTCCGCCTTCAAGGCCGGGCTGAACGCCCCGCTCTTCACCGACTCGCCCGAGACCGTGGCCACTGCAA
TAAGGATAGGGAAGCCCGTGAACTGGATGAAGGCTTGGAAGGCCGTGACGGAGTCCGGGGGAACCTTCGAGGTAGTTTCG
GACTCTGAAATCATAAGGGCCCAAAGGCTCCTCGCGAGGGAGGAGGGCGTGGCGGCCGAGCCGGCGGGCGCGGCGAGCTT
GGCCGGGGTGGTGAGGCTGGCCTCTGAGGGCTACTTCAACGGGGACGAAGTGGTAACCGTGGTGGTCACGGGCCACGGGC
TGAAGGACCCGGACAGCGTGAAGTTCCACCCCGCGAACAAGCTGACGGCCTTGAACGTAGAGGACGCGGTGGAGAAGGTC
GTAAGCGCGTTGAAGGTGGTCGCTTGA

Upstream 100 bases:

>100_bases
GGGAGCAAGTAGCTCAAGCCCCTCCCTCGCTCCAAACTTTTCTAAGCTTTCGATAATTAGTTAACGTCCCGGAGCTGGGC
GCTTGGAGGGAAGGAGCTCA

Downstream 100 bases:

>100_bases
GGCCTCCCAAGCTCTTCCTCCTCCTCTCCTACGCGCTGATCTTCGCTTCCCTCCTCTCCGGCCCCCTCTTCTGGGCCCTC
TTCGCCTCCGGCGCGCTCCT

Product: L-threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MRAKLRCVRCGAEYDVQPKMFSCPKCGGLLEVVIEPEELPPFSEFTKRSRMKGIWRFAELLPVKSGSPVTMGEGNTPLIR
LEKLEKVIGVRRLYAKFEGANPTGSFKDRGMSLAVTVAKEVKARAVVAASTGNTAASAAAYSARAGLKTFLILPSGKVAL
GKLAQSLLHGAVVVELEGNFDAALEAVKELAKMPEFYPLNSFNPWRLEGQKTLAFELFEEIGVPDVVVVPVGNAGNISAI
WKGFKELKEFGYSEALPKMVGVQAEGASPIASAFKAGLNAPLFTDSPETVATAIRIGKPVNWMKAWKAVTESGGTFEVVS
DSEIIRAQRLLAREEGVAAEPAGAASLAGVVRLASEGYFNGDEVVTVVVTGHGLKDPDSVKFHPANKLTALNVEDAVEKV
VSALKVVA

Sequences:

>Translated_408_residues
MRAKLRCVRCGAEYDVQPKMFSCPKCGGLLEVVIEPEELPPFSEFTKRSRMKGIWRFAELLPVKSGSPVTMGEGNTPLIR
LEKLEKVIGVRRLYAKFEGANPTGSFKDRGMSLAVTVAKEVKARAVVAASTGNTAASAAAYSARAGLKTFLILPSGKVAL
GKLAQSLLHGAVVVELEGNFDAALEAVKELAKMPEFYPLNSFNPWRLEGQKTLAFELFEEIGVPDVVVVPVGNAGNISAI
WKGFKELKEFGYSEALPKMVGVQAEGASPIASAFKAGLNAPLFTDSPETVATAIRIGKPVNWMKAWKAVTESGGTFEVVS
DSEIIRAQRLLAREEGVAAEPAGAASLAGVVRLASEGYFNGDEVVTVVVTGHGLKDPDSVKFHPANKLTALNVEDAVEKV
VSALKVVA
>Mature_408_residues
MRAKLRCVRCGAEYDVQPKMFSCPKCGGLLEVVIEPEELPPFSEFTKRSRMKGIWRFAELLPVKSGSPVTMGEGNTPLIR
LEKLEKVIGVRRLYAKFEGANPTGSFKDRGMSLAVTVAKEVKARAVVAASTGNTAASAAAYSARAGLKTFLILPSGKVAL
GKLAQSLLHGAVVVELEGNFDAALEAVKELAKMPEFYPLNSFNPWRLEGQKTLAFELFEEIGVPDVVVVPVGNAGNISAI
WKGFKELKEFGYSEALPKMVGVQAEGASPIASAFKAGLNAPLFTDSPETVATAIRIGKPVNWMKAWKAVTESGGTFEVVS
DSEIIRAQRLLAREEGVAAEPAGAASLAGVVRLASEGYFNGDEVVTVVVTGHGLKDPDSVKFHPANKLTALNVEDAVEKV
VSALKVVA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=284, Percent_Identity=27.4647887323944, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1790207, Length=338, Percent_Identity=30.1775147928994, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789505, Length=283, Percent_Identity=27.208480565371, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=280, Percent_Identity=25.3571428571429, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 43475; Mature: 43475

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKLRCVRCGAEYDVQPKMFSCPKCGGLLEVVIEPEELPPFSEFTKRSRMKGIWRFAEL
CCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LPVKSGSPVTMGEGNTPLIRLEKLEKVIGVRRLYAKFEGANPTGSFKDRGMSLAVTVAKE
HCCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEEHHH
VKARAVVAASTGNTAASAAAYSARAGLKTFLILPSGKVALGKLAQSLLHGAVVVELEGNF
HCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCH
DAALEAVKELAKMPEFYPLNSFNPWRLEGQKTLAFELFEEIGVPDVVVVPVGNAGNISAI
HHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHH
WKGFKELKEFGYSEALPKMVGVQAEGASPIASAFKAGLNAPLFTDSPETVATAIRIGKPV
HHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCH
NWMKAWKAVTESGGTFEVVSDSEIIRAQRLLAREEGVAAEPAGAASLAGVVRLASEGYFN
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
GDEVVTVVVTGHGLKDPDSVKFHPANKLTALNVEDAVEKVVSALKVVA
CCCEEEEEEECCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRAKLRCVRCGAEYDVQPKMFSCPKCGGLLEVVIEPEELPPFSEFTKRSRMKGIWRFAEL
CCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
LPVKSGSPVTMGEGNTPLIRLEKLEKVIGVRRLYAKFEGANPTGSFKDRGMSLAVTVAKE
HCCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEEEHHH
VKARAVVAASTGNTAASAAAYSARAGLKTFLILPSGKVALGKLAQSLLHGAVVVELEGNF
HCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCEEEEEECCCH
DAALEAVKELAKMPEFYPLNSFNPWRLEGQKTLAFELFEEIGVPDVVVVPVGNAGNISAI
HHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHH
WKGFKELKEFGYSEALPKMVGVQAEGASPIASAFKAGLNAPLFTDSPETVATAIRIGKPV
HHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCH
NWMKAWKAVTESGGTFEVVSDSEIIRAQRLLAREEGVAAEPAGAASLAGVVRLASEGYFN
HHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
GDEVVTVVVTGHGLKDPDSVKFHPANKLTALNVEDAVEKVVSALKVVA
CCCEEEEEEECCCCCCCCCEEEECCCCEEEECHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]