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The map label for this gene is trpA [H]

Identifier: 156937225

GI number: 156937225

Start: 383194

End: 383946

Strand: Reverse

Name: trpA [H]

Synonym: Igni_0431

Alternate gene names: 156937225

Gene position: 383946-383194 (Counterclockwise)

Preceding gene: 156937226

Following gene: 156937224

Centisome position: 29.59

GC content: 58.96

Gene sequence:

>753_bases
TTGAAGGTGGACCCCTCCAAGAGGCCTTGGCTGGTGGCCTACCTAACCTTGAACTACCCCGACGAACGGACCTTCCTCAA
GGCCTTGGAGTACTTGAAGGATAAGGCGGAGCTCGTGGAGATAGGCATACCCCCGAAGTTCGCCAAGTACGACGGGCCCA
CAATAAGGAGGAGCTACAAGGCGGTCTCCTCCAAGGGCTTGGGCTTACACAACTTCGAGGGGGAGCTGCGCAAGGCTTGT
CGCGCCTTCCCGGAAGAAAGAATAATTGTGATGACATATTATGACGACGTTAAGGAGAACTACGAAGAGTTCTTGGATAA
GGCGTGCGGAGGGGGAGTGCTCTTCGCGGACGCCGTCATAGACTTCGCGGACCGCTTGGAGGAGATCGCGAGTAAGGCGA
AGGAGCGCGGCAAGAGCGCGGTGTTCTTCGTCTCCCCCACCACCCCCGACCACGTGATAAGGAAGGCCGCGGAGCTGAGC
GACCCGGTGGTTTACCTAGGCGTCAGGCCGGCCACCGGGATCCCCCTGCCCGTAGGGATACCGAACTTGCTGAGGAGGGT
GAAGTCTTTGACCAACAAGTACGTGGTAGTGGGCTTCGGCTTGAAGGAAGAGGAGGTCCCCCAAGCGGTGGGAGCGGGGG
CGGACGGGGTAGTGGTGGGGAGCGCTTTGGTTAAGGCCTTAGGGGAGGGCTTCGATAACTTCAAAAAGGTGGTGGATAGG
TACTTGGCCCTCCTCAGCCTCCCCAAGAGATGA

Upstream 100 bases:

>100_bases
GTTTTTTCGTTTCCGGAAGTGAGGACTCCGGCAGGAGCCGAGGGGGTGAGGAAACGCCGATAGTCCGACTCCTCGGGTCG
CCCTAGGCGAAGGGGAGTTG

Downstream 100 bases:

>100_bases
CCAGCCCGCCGGGCCCGGAGGAGGTGGTCAAGCTGAAAGTTATTTCCGAGGTGACCGCGCTCGCCGCCCCTCCGGCTATC
GCGCAGTAGGGCGCGCTGGG

Product: tryptophan synthase, alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 250; Mature: 250

Protein sequence:

>250_residues
MKVDPSKRPWLVAYLTLNYPDERTFLKALEYLKDKAELVEIGIPPKFAKYDGPTIRRSYKAVSSKGLGLHNFEGELRKAC
RAFPEERIIVMTYYDDVKENYEEFLDKACGGGVLFADAVIDFADRLEEIASKAKERGKSAVFFVSPTTPDHVIRKAAELS
DPVVYLGVRPATGIPLPVGIPNLLRRVKSLTNKYVVVGFGLKEEEVPQAVGAGADGVVVGSALVKALGEGFDNFKKVVDR
YLALLSLPKR

Sequences:

>Translated_250_residues
MKVDPSKRPWLVAYLTLNYPDERTFLKALEYLKDKAELVEIGIPPKFAKYDGPTIRRSYKAVSSKGLGLHNFEGELRKAC
RAFPEERIIVMTYYDDVKENYEEFLDKACGGGVLFADAVIDFADRLEEIASKAKERGKSAVFFVSPTTPDHVIRKAAELS
DPVVYLGVRPATGIPLPVGIPNLLRRVKSLTNKYVVVGFGLKEEEVPQAVGAGADGVVVGSALVKALGEGFDNFKKVVDR
YLALLSLPKR
>Mature_250_residues
MKVDPSKRPWLVAYLTLNYPDERTFLKALEYLKDKAELVEIGIPPKFAKYDGPTIRRSYKAVSSKGLGLHNFEGELRKAC
RAFPEERIIVMTYYDDVKENYEEFLDKACGGGVLFADAVIDFADRLEEIASKAKERGKSAVFFVSPTTPDHVIRKAAELS
DPVVYLGVRPATGIPLPVGIPNLLRRVKSLTNKYVVVGFGLKEEEVPQAVGAGADGVVVGSALVKALGEGFDNFKKVVDR
YLALLSLPKR

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321412, Length=234, Percent_Identity=30.3418803418803, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 27638; Mature: 27638

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVDPSKRPWLVAYLTLNYPDERTFLKALEYLKDKAELVEIGIPPKFAKYDGPTIRRSYK
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
AVSSKGLGLHNFEGELRKACRAFPEERIIVMTYYDDVKENYEEFLDKACGGGVLFADAVI
HHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEHHHHHH
DFADRLEEIASKAKERGKSAVFFVSPTTPDHVIRKAAELSDPVVYLGVRPATGIPLPVGI
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
PNLLRRVKSLTNKYVVVGFGLKEEEVPQAVGAGADGVVVGSALVKALGEGFDNFKKVVDR
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
YLALLSLPKR
HHHHHHCCCC
>Mature Secondary Structure
MKVDPSKRPWLVAYLTLNYPDERTFLKALEYLKDKAELVEIGIPPKFAKYDGPTIRRSYK
CCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHH
AVSSKGLGLHNFEGELRKACRAFPEERIIVMTYYDDVKENYEEFLDKACGGGVLFADAVI
HHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCEEHHHHHH
DFADRLEEIASKAKERGKSAVFFVSPTTPDHVIRKAAELSDPVVYLGVRPATGIPLPVGI
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCC
PNLLRRVKSLTNKYVVVGFGLKEEEVPQAVGAGADGVVVGSALVKALGEGFDNFKKVVDR
HHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHH
YLALLSLPKR
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]