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The map label for this gene is mre11 [H]

Identifier: 156937073

GI number: 156937073

Start: 239556

End: 240710

Strand: Reverse

Name: mre11 [H]

Synonym: Igni_0278

Alternate gene names: 156937073

Gene position: 240710-239556 (Counterclockwise)

Preceding gene: 156937074

Following gene: 156937069

Centisome position: 18.55

GC content: 60.43

Gene sequence:

>1155_bases
TTGCTGATCGTCCACGCCGCCGACGTCCACTTGGGCAAGAGGCAGTACGGCTTGAAGGAGAGGGAGGAGGACTTCTACAA
GGCCTTCGAAGACTTGGTGGAAGCCACGATAAGGGAGAAGGCCGACGCCCTCGTAATAGCTGGAGACTTGTTCGACACCC
CCGTGCCGGACAGCACAATGAAGCCGTTCAAGGTCGCGGTCGAAGGGGTAAGGAGGCTGAGGGAAAATGGCATAGAAGTG
ATAATGGTTGCCGGGGACCACGACATACCGAAGGTGAGGGGATATCCAGCTATAGCTTACTTGAGCGAGCTGACCGGGGC
CAAGCTGCTCAGGGGGGAGCTGGGGGCCAAGGGGTACGAGCTCAAGGGCTTTACCTTCTACGGGGACGACGCCGTCACCC
CCTCCAAGAGGGGGCCCCTGGAGCGCTTGAGGGCGGTCAAACCTAAGAAGAACTCCGTCTTGCTCCTTCACGTAGGCCTG
TGCAGGGCGCTCCCCTTCAGCTGTGTGGACGAGGGCCTGTTGCCCAAGGGCTACAAGTACTACGCGCTCGGCCACGTCCA
CAAGCCCACAGTCTTGGAGGTCCACGGGGCGCCCGCCGCCTACCCGGGCTCCTTGGAGGCCACCACAGTTGACGAGGTGT
TGTGGGAGTCTTCGGACAACCCGTTGTTGAGGCGGGGACCCTTGCTTGTGGACTTAGGGGGCGACGAGGCCCAGATAGTA
GGCAAGTTAAACGTATACAACAGGAAGCAGATAATAAAGAAGTACGAGTTACCGAAGGACTACAAGAGGGCGCTCGCGGA
GGCGGAGTCCGTACCCCAAGGCGCGGTGGTGCACCTTTACCTAACCGGCAAGGTGGGTAAGGACGCCGTAAGGGCGATAT
CCTCCAAGTTCCAAGCGAGGGCGTTGACCGTGAGGGTGAACTTCCTCGCGGAGGAGGAAGAGGAAGTGGAGGAGACCGTC
ACGAACTTTACGGGGCTGGAGGACTTGATAATAGAGTTCTACGGGAAGGAGCTCGGCCGGCTCCTCTACGAGCTCGTGAA
GGCGGCACAAGAGAGGAGGTCCGACGAGCTCAAGAGGGTCGCCGAGGAGATCTTCGAGAGCGGAGCGTGGCGTAGAGCTC
AGCGTGCCTCCTCGCAACGCGGTCGACGGCGGTGA

Upstream 100 bases:

>100_bases
TTAGGGCTGTGGGGCTGCTACCGGAGGGCCGTGAGCGGATCGAGGTAAGCCGAGGCGAGTGAGGTAGTTATCCCCGGGCG
AGCCCTCAAGGGTGGTCGCG

Downstream 100 bases:

>100_bases
AGCGCGCGTACGCCAAGGCCCCCGGGTTGCACAAGTTGCCCCTCAAAACCTCGTCTATCGCCCTCCTCAAGGCTTGTTTC
ATCGTAGGCAGCGGGTCGTC

Product: metallophosphoesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MLIVHAADVHLGKRQYGLKEREEDFYKAFEDLVEATIREKADALVIAGDLFDTPVPDSTMKPFKVAVEGVRRLRENGIEV
IMVAGDHDIPKVRGYPAIAYLSELTGAKLLRGELGAKGYELKGFTFYGDDAVTPSKRGPLERLRAVKPKKNSVLLLHVGL
CRALPFSCVDEGLLPKGYKYYALGHVHKPTVLEVHGAPAAYPGSLEATTVDEVLWESSDNPLLRRGPLLVDLGGDEAQIV
GKLNVYNRKQIIKKYELPKDYKRALAEAESVPQGAVVHLYLTGKVGKDAVRAISSKFQARALTVRVNFLAEEEEEVEETV
TNFTGLEDLIIEFYGKELGRLLYELVKAAQERRSDELKRVAEEIFESGAWRRAQRASSQRGRRR

Sequences:

>Translated_384_residues
MLIVHAADVHLGKRQYGLKEREEDFYKAFEDLVEATIREKADALVIAGDLFDTPVPDSTMKPFKVAVEGVRRLRENGIEV
IMVAGDHDIPKVRGYPAIAYLSELTGAKLLRGELGAKGYELKGFTFYGDDAVTPSKRGPLERLRAVKPKKNSVLLLHVGL
CRALPFSCVDEGLLPKGYKYYALGHVHKPTVLEVHGAPAAYPGSLEATTVDEVLWESSDNPLLRRGPLLVDLGGDEAQIV
GKLNVYNRKQIIKKYELPKDYKRALAEAESVPQGAVVHLYLTGKVGKDAVRAISSKFQARALTVRVNFLAEEEEEVEETV
TNFTGLEDLIIEFYGKELGRLLYELVKAAQERRSDELKRVAEEIFESGAWRRAQRASSQRGRRR
>Mature_384_residues
MLIVHAADVHLGKRQYGLKEREEDFYKAFEDLVEATIREKADALVIAGDLFDTPVPDSTMKPFKVAVEGVRRLRENGIEV
IMVAGDHDIPKVRGYPAIAYLSELTGAKLLRGELGAKGYELKGFTFYGDDAVTPSKRGPLERLRAVKPKKNSVLLLHVGL
CRALPFSCVDEGLLPKGYKYYALGHVHKPTVLEVHGAPAAYPGSLEATTVDEVLWESSDNPLLRRGPLLVDLGGDEAQIV
GKLNVYNRKQIIKKYELPKDYKRALAEAESVPQGAVVHLYLTGKVGKDAVRAISSKFQARALTVRVNFLAEEEEEVEETV
TNFTGLEDLIIEFYGKELGRLLYELVKAAQERRSDELKRVAEEIFESGAWRRAQRASSQRGRRR

Specific function: Involved in DNA double-strand break repair (DSBR). The rad50/mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity [H]

COG id: COG0420

COG function: function code L; DNA repair exonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MRE11/RAD32 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003701
- InterPro:   IPR004843 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: NA

Molecular weight: Translated: 42874; Mature: 42874

Theoretical pI: Translated: 8.17; Mature: 8.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIVHAADVHLGKRQYGLKEREEDFYKAFEDLVEATIREKADALVIAGDLFDTPVPDSTM
CEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
KPFKVAVEGVRRLRENGIEVIMVAGDHDIPKVRGYPAIAYLSELTGAKLLRGELGAKGYE
CHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
LKGFTFYGDDAVTPSKRGPLERLRAVKPKKNSVLLLHVGLCRALPFSCVDEGLLPKGYKY
ECEEEEECCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECHHHHCCHHHHCCCCCCCCCEE
YALGHVHKPTVLEVHGAPAAYPGSLEATTVDEVLWESSDNPLLRRGPLLVDLGGDEAQIV
EEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCEEEEECCCCEEEE
GKLNVYNRKQIIKKYELPKDYKRALAEAESVPQGAVVHLYLTGKVGKDAVRAISSKFQAR
EEECHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHE
ALTVRVNFLAEEEEEVEETVTNFTGLEDLIIEFYGKELGRLLYELVKAAQERRSDELKRV
EEEEEEEEHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEEIFESGAWRRAQRASSQRGRRR
HHHHHHCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLIVHAADVHLGKRQYGLKEREEDFYKAFEDLVEATIREKADALVIAGDLFDTPVPDSTM
CEEEEECCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
KPFKVAVEGVRRLRENGIEVIMVAGDHDIPKVRGYPAIAYLSELTGAKLLRGELGAKGYE
CHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEE
LKGFTFYGDDAVTPSKRGPLERLRAVKPKKNSVLLLHVGLCRALPFSCVDEGLLPKGYKY
ECEEEEECCCCCCCCCCCCHHHHHCCCCCCCCEEEEEECHHHHCCHHHHCCCCCCCCCEE
YALGHVHKPTVLEVHGAPAAYPGSLEATTVDEVLWESSDNPLLRRGPLLVDLGGDEAQIV
EEECCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCEECCCEEEEECCCCEEEE
GKLNVYNRKQIIKKYELPKDYKRALAEAESVPQGAVVHLYLTGKVGKDAVRAISSKFQAR
EEECHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHE
ALTVRVNFLAEEEEEVEETVTNFTGLEDLIIEFYGKELGRLLYELVKAAQERRSDELKRV
EEEEEEEEHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEEIFESGAWRRAQRASSQRGRRR
HHHHHHCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11427726 [H]