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The map label for this gene is rph [C]

Identifier: 156937004

GI number: 156937004

Start: 185567

End: 186397

Strand: Reverse

Name: rph [C]

Synonym: Igni_0209

Alternate gene names: 156937004

Gene position: 186397-185567 (Counterclockwise)

Preceding gene: 156937005

Following gene: 156937003

Centisome position: 14.37

GC content: 57.64

Gene sequence:

>831_bases
ATGTCCATAACGCCGTTTAACGTCCCTATCGTGCCCAAGCTGAAGAGGGATACCATACTGTCCCTCGCCAAGAGGGGGAC
GAGGATAGACAAGAGGAGGCTCGACCAGTATCGGCCAATCAAAATAACGCTAGGCGTAGGTGGGAAGGCCCACGGGAGCG
CTTTGGTAGAGATAGGCAACACCAAGGTTCTAGCCGGCGTAAAGGTCGAGGTGGGGAAGCCCTTCAAGGACGTCCCGGAC
GCCGGGGTGCTTAACGTAAACGCCGAGCTGCTCCCGCTGGCCTCCTCGGAGTTCGAGCCGGGCCCGCCGGACGAGAACGC
GATAGAGCTGGCGAGGGTCATAGACCGCGCTCTGAGGGAGCCCGGAGTGATAGACTTGAAGGAGTTAGTCCTCATACCCG
GCGAGAAAGTATTAGTAGTGTGGTTGGACGTTTACGTGCTCGACCACGACGGCAACTTGTTCGACGCATCCATGCTAGCG
TCCATGGCCGCGCTGTTAGACACTAGGTACCCAGAATACGTCGTCCGGGAGGACGGGAGCGTGGAGGTAGACGAGGCCAA
CAAGAGGCCGCTACCGATAGCTAACAAGGTGGTTAGCGTAACGCTGAACGTGCTCGAGAACTTGTTTATGGTAGACCCGA
CGCTGGAGGAAGAAGTGGTGGCGGACGGGAAGATAGTCTTCGCGTTCGACGAAAGGGGGAGGTTGGTGGGACTACAGAAG
AGCGGGCCCGCTTGGCTGGACTTGGATAAGAGTACCACTGCCTTCAACTTGGCCTACTCCAAGTATAAGGAGCTGTTGGA
GGTCCTAGAGAAGAGCTTAGCGGAGCGCTGA

Upstream 100 bases:

>100_bases
GTTCCCCCAAGCCCTCAAGCTGGCTTGGGAGGGCATCAAGAAAATTCATGCAATGCAGAAGAAGGTCTTAGCGGAGAAGT
ACGGCGGGGGTGAGGCCTAA

Downstream 100 bases:

>100_bases
CCTTACGTTCACGTACTTTAAGTGGTCTAAAGGTACAGAACGTCTGATTACTGCGTCTGTAACATCAGACTCCGGGACGA
CCGTTTGCAATGTGTAGAAG

Product: exosome complex RNA-binding protein Rrp42

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MSITPFNVPIVPKLKRDTILSLAKRGTRIDKRRLDQYRPIKITLGVGGKAHGSALVEIGNTKVLAGVKVEVGKPFKDVPD
AGVLNVNAELLPLASSEFEPGPPDENAIELARVIDRALREPGVIDLKELVLIPGEKVLVVWLDVYVLDHDGNLFDASMLA
SMAALLDTRYPEYVVREDGSVEVDEANKRPLPIANKVVSVTLNVLENLFMVDPTLEEEVVADGKIVFAFDERGRLVGLQK
SGPAWLDLDKSTTAFNLAYSKYKELLEVLEKSLAER

Sequences:

>Translated_276_residues
MSITPFNVPIVPKLKRDTILSLAKRGTRIDKRRLDQYRPIKITLGVGGKAHGSALVEIGNTKVLAGVKVEVGKPFKDVPD
AGVLNVNAELLPLASSEFEPGPPDENAIELARVIDRALREPGVIDLKELVLIPGEKVLVVWLDVYVLDHDGNLFDASMLA
SMAALLDTRYPEYVVREDGSVEVDEANKRPLPIANKVVSVTLNVLENLFMVDPTLEEEVVADGKIVFAFDERGRLVGLQK
SGPAWLDLDKSTTAFNLAYSKYKELLEVLEKSLAER
>Mature_275_residues
SITPFNVPIVPKLKRDTILSLAKRGTRIDKRRLDQYRPIKITLGVGGKAHGSALVEIGNTKVLAGVKVEVGKPFKDVPDA
GVLNVNAELLPLASSEFEPGPPDENAIELARVIDRALREPGVIDLKELVLIPGEKVLVVWLDVYVLDHDGNLFDASMLAS
MAALLDTRYPEYVVREDGSVEVDEANKRPLPIANKVVSVTLNVLENLFMVDPTLEEEVVADGKIVFAFDERGRLVGLQKS
GPAWLDLDKSTTAFNLAYSKYKELLEVLEKSLAER

Specific function: Probably involved in the 3'->5' degradation of a variety of RNA species (Potential) [H]

COG id: COG2123

COG function: function code J; RNase PH-related exoribonuclease

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase PH family [H]

Homologues:

Organism=Homo sapiens, GI31415882, Length=250, Percent_Identity=35.6, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI77812670, Length=267, Percent_Identity=31.8352059925094, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI77812672, Length=267, Percent_Identity=31.8352059925094, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI189083688, Length=226, Percent_Identity=33.1858407079646, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI157672248, Length=216, Percent_Identity=28.2407407407407, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144570, Length=263, Percent_Identity=30.0380228136882, Blast_Score=127, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6320486, Length=275, Percent_Identity=29.4545454545455, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24642649, Length=274, Percent_Identity=32.8467153284672, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28573444, Length=199, Percent_Identity=30.6532663316583, Blast_Score=91, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001247
- InterPro:   IPR015847
- InterPro:   IPR020869
- InterPro:   IPR020568 [H]

Pfam domain/function: PF01138 RNase_PH; PF03725 RNase_PH_C [H]

EC number: 3.1.13.-

Molecular weight: Translated: 30350; Mature: 30218

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITPFNVPIVPKLKRDTILSLAKRGTRIDKRRLDQYRPIKITLGVGGKAHGSALVEIGN
CCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECC
TKVLAGVKVEVGKPFKDVPDAGVLNVNAELLPLASSEFEPGPPDENAIELARVIDRALRE
EEEEEEEEEECCCCCCCCCCCCEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
PGVIDLKELVLIPGEKVLVVWLDVYVLDHDGNLFDASMLASMAALLDTRYPEYVVREDGS
CCCEEHHHEEECCCCEEEEEEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCEEEECCCC
VEVDEANKRPLPIANKVVSVTLNVLENLFMVDPTLEEEVVADGKIVFAFDERGRLVGLQK
EEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCEEEEEECCCCCEEEEEC
SGPAWLDLDKSTTAFNLAYSKYKELLEVLEKSLAER
CCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SITPFNVPIVPKLKRDTILSLAKRGTRIDKRRLDQYRPIKITLGVGGKAHGSALVEIGN
CCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECC
TKVLAGVKVEVGKPFKDVPDAGVLNVNAELLPLASSEFEPGPPDENAIELARVIDRALRE
EEEEEEEEEECCCCCCCCCCCCEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
PGVIDLKELVLIPGEKVLVVWLDVYVLDHDGNLFDASMLASMAALLDTRYPEYVVREDGS
CCCEEHHHEEECCCCEEEEEEEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCEEEECCCC
VEVDEANKRPLPIANKVVSVTLNVLENLFMVDPTLEEEVVADGKIVFAFDERGRLVGLQK
EEECCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCHHHHHCCCEEEEEECCCCCEEEEEC
SGPAWLDLDKSTTAFNLAYSKYKELLEVLEKSLAER
CCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]