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The map label for this gene is hisA [H]

Identifier: 156936972

GI number: 156936972

Start: 157892

End: 158599

Strand: Reverse

Name: hisA [H]

Synonym: Igni_0177

Alternate gene names: 156936972

Gene position: 158599-157892 (Counterclockwise)

Preceding gene: 156936985

Following gene: 156936971

Centisome position: 12.22

GC content: 56.64

Gene sequence:

>708_bases
ATGAGGGTTTTTCCTAGCATAGACGTGTCGGAGGGGCGGGCAGTAAAGAGGGTAAGGGGTGTCAAGGGCACCGGCTTGGA
CCTGGGCGATCCGGTCAAGTGGGCCGAATTCTGGGCGCTCGAGGGAGCCAAGGGGCTTCACGTAGTAGACTTGGACGGCG
CAGAGGCAGGAAAGCCGATAAACGTTGAGGTGATAAACAAAGTAATAGAGAAGGCGAAGGAGTACGGGCTGTGGGTCCAA
GTCGCAGGGGGCTTAAGGGAAGTAGAACACTTAGAGCGCTACCCTAAAGCAGACGCATTCGTCATTGGTAGTAGGGCCCA
CAAGGATCCGGAGTTCCTAGAGGTCGCCTCGGAAGCGGTCGGGGCGGACAAGGTAATCGTCGCAATAGACTTGAAAGGAG
GCAAGGTAAGCGTCGAAGGATGGAAGGAAGAGATACCCGTAGGTCTGAAGGAGGCACTCGAGAAGTTTAAGGGAAGGTCC
TTTAGGGGTTTCCTCTACACTTACGTGGACACTGAAGGAACTATGGAAGGGCCCGACGTGAGCGGCGTCAAGTACATTAG
AAGGGAGTACCCGGACAAGCTCCTAGAGTACGCCGGGGGCGTGGGGAGTCCGGAGCACGTGAAGCTCTTGGAGAGCGCCG
GGGCGGACGTGGTCGTTTTGGGGATGGCTTTATATTCCGGCAAGCTGCGCCTCAAGGATCTGGTGTAG

Upstream 100 bases:

>100_bases
ACTTCGCTAAGTAAACCTCCGCCTCGGCTCCCTTAGCCAGGAGGTTCAAGACCTCCAGTATTTACCTCACCCGCCGTCCG
GTCCCCCCGGCTGGACGGAA

Downstream 100 bases:

>100_bases
GGAATGGGCTTCTGGCCAAACAAGAGGGAGATGAGCGTTTACTATTTGCTCAAGAAGCGCTTCGGGGACCGCTTTAACCT
GGGAGAGGGCCTAGAGGTCT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRVFPSIDVSEGRAVKRVRGVKGTGLDLGDPVKWAEFWALEGAKGLHVVDLDGAEAGKPINVEVINKVIEKAKEYGLWVQ
VAGGLREVEHLERYPKADAFVIGSRAHKDPEFLEVASEAVGADKVIVAIDLKGGKVSVEGWKEEIPVGLKEALEKFKGRS
FRGFLYTYVDTEGTMEGPDVSGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDLV

Sequences:

>Translated_235_residues
MRVFPSIDVSEGRAVKRVRGVKGTGLDLGDPVKWAEFWALEGAKGLHVVDLDGAEAGKPINVEVINKVIEKAKEYGLWVQ
VAGGLREVEHLERYPKADAFVIGSRAHKDPEFLEVASEAVGADKVIVAIDLKGGKVSVEGWKEEIPVGLKEALEKFKGRS
FRGFLYTYVDTEGTMEGPDVSGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDLV
>Mature_235_residues
MRVFPSIDVSEGRAVKRVRGVKGTGLDLGDPVKWAEFWALEGAKGLHVVDLDGAEAGKPINVEVINKVIEKAKEYGLWVQ
VAGGLREVEHLERYPKADAFVIGSRAHKDPEFLEVASEAVGADKVIVAIDLKGGKVSVEGWKEEIPVGLKEALEKFKGRS
FRGFLYTYVDTEGTMEGPDVSGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDLV

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=241, Percent_Identity=29.045643153527, Blast_Score=97, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 25608; Mature: 25608

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFPSIDVSEGRAVKRVRGVKGTGLDLGDPVKWAEFWALEGAKGLHVVDLDGAEAGKPI
CCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCC
NVEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPKADAFVIGSRAHKDPEFLEVASEAV
CHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHC
GADKVIVAIDLKGGKVSVEGWKEEIPVGLKEALEKFKGRSFRGFLYTYVDTEGTMEGPDV
CCCEEEEEEECCCCEEEECCCHHHCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
SGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDLV
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHCCCEEEECCC
>Mature Secondary Structure
MRVFPSIDVSEGRAVKRVRGVKGTGLDLGDPVKWAEFWALEGAKGLHVVDLDGAEAGKPI
CCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCCCC
NVEVINKVIEKAKEYGLWVQVAGGLREVEHLERYPKADAFVIGSRAHKDPEFLEVASEAV
CHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHC
GADKVIVAIDLKGGKVSVEGWKEEIPVGLKEALEKFKGRSFRGFLYTYVDTEGTMEGPDV
CCCEEEEEEECCCCEEEECCCHHHCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
SGVKYIRREYPDKLLEYAGGVGSPEHVKLLESAGADVVVLGMALYSGKLRLKDLV
HHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA