Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is isp [H]

Identifier: 15675802

GI number: 15675802

Start: 1688021

End: 1689646

Strand: Reverse

Name: isp [H]

Synonym: SPy_2025

Alternate gene names: 15675802

Gene position: 1689646-1688021 (Counterclockwise)

Preceding gene: 15675803

Following gene: 15675801

Centisome position: 91.21

GC content: 44.53

Gene sequence:

>1626_bases
ATGAAGAAAAGGAAATTGTTAGCAGTAACACTATTAAGTACCATACTCTTAAACAGTGCAGTGCCATTAGTTGTTGCTGA
TACCTCCTTGCGTAATAGCACATCATCCACTGATCAGCCTACTACAGCAGATACTGATACGGATGACGAGAGTGAAACAC
CAAAAAAAGACAAAAAAAGCAAGGAAACAGCGTCGCAGCACGACACCCAAAAAGACCATAAGCCATCACACACTCACCCA
ACCCCCCCTTCAAATGATACTAAGCAGACCGATCAGGCATCATCTGAAGCTACTGACAAACCAAATAAAGACAAAAACGA
CACCAAGCAACCAGACAGCAGTGATCAATCCACCCCATCTCCCAAAGACCAGTCGTCTCAAAAAGAGTCACAAAACAAAG
ACGGCCGACCTACCCCATCACCTGATCAGCAAAAAGATCAGACACCTGATAAAACACCAGAAAAATCAGCTGATAAAACC
CCTGAAAAAGGACCAGAAAAAGCAACTGATAAAACACCAGAGCCAAATCGTGACGCTCCAAAACCCATCCAACCTCCTTT
AGCAGCTGCTCCTGTCTTTATACCTTGGAGAGAAAGTGACAAAGACCTGAGCAAGCTAAAACCAAGCAGTCGCTCATCAG
CGGCTTACGTGAGACACTGGACAGGTGACTCTGCCTACACTCACAACCTGTTGTCACGCCGTTATGGGATTACTGCTGAA
CAGCTAGATGGTTTTTTGAACAGTCTAGGTATTCACTATGATAAAGAACGCTTAAACGGAAAGCGTTTATTAGAATGGGA
AAAACTAACAGGACTAGACGTTCGAGCTATCGTAGCTATTGCAATGGCAGAAAGCTCACTAGGTACTCAGGGAGTTGCTA
AAGAAAAAGGAGCCAATATGTTTGGTTATGGCGCCTTTGACTTCAACCCAAACAATGCCAAAAAATACAGCGATGAGGTT
GCTATTCGTCACATGGTAGAAGACACCATCATTGCCAACAAAAACCAAACCTTTGAAAGACAAGACCTCAAAGCAAAAAA
ATGGTCACTAGGCCAGTTGGATACCTTGATTGATGGTGGGGTTTACTTTACAGATACAAGTGGCAGTGGGCAAAGACGAG
CAGATATCATGACCAAACTAGACCAATGGATAGATGATCATGGAAGCACACCTGAGATTCCAGAACATCTCAAGATAACT
TCCGGGACACAATTTAGCGAAGTGCCCGTAGGTTATAAAAGAAGTCAGCCACAAAACGTTTTGACCTACAAGTCAGAGAC
CTACAGCTTTGGCCAATGCACTTGGTACGCCTATAATCGTGTCAAAGAGCTAGGTTATCAAGTCGACAGGTACATGGGTA
ACGGTGGCGACTGGCAGCGCAAGCCAGGTTTTGTGACCACCCATAAACCTAAAGTGGGCTATGTCGTCTCATTTGCACCA
GGCCAAGCAGGAGCAGATGCAACCTATGGTCACGTTGCTGTTGTAGAGCAAATCAAAGAAGATGGTTCTATCTTAATTTC
AGAGTCAAATGTTATGGGACTAGGCACCATTTCCTATCGGACGTTCACAGCTGAGCAGGCTAGTTTGTTGACCTATGTCG
TAGGGGACAAACTCCCAAGACCATAA

Upstream 100 bases:

>100_bases
CCATACTAGTAGGACGACAAAAGTCATCAATCATTAACCAAGCCTTGACCTTTACCCATCATTGTTTAGGCAAGTATAAA
AAAGAGGAGAGAAATCATAT

Downstream 100 bases:

>100_bases
CCCCCACAACCAAGAAGCTACCTGCCTGTTGACCAATCTCAAAAAGAGACAGCGTCAACTTAGAATGAGGTTCATCAGAT
GATAAAGAAAGTGACCACCC

Product: immunogenic secreted protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKKRKLLAVTLLSTILLNSAVPLVVADTSLRNSTSSTDQPTTADTDTDDESETPKKDKKSKETASQHDTQKDHKPSHTHP
TPPSNDTKQTDQASSEATDKPNKDKNDTKQPDSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKT
PEKGPEKATDKTPEPNRDAPKPIQPPLAAAPVFIPWRESDKDLSKLKPSSRSSAAYVRHWTGDSAYTHNLLSRRYGITAE
QLDGFLNSLGIHYDKERLNGKRLLEWEKLTGLDVRAIVAIAMAESSLGTQGVAKEKGANMFGYGAFDFNPNNAKKYSDEV
AIRHMVEDTIIANKNQTFERQDLKAKKWSLGQLDTLIDGGVYFTDTSGSGQRRADIMTKLDQWIDDHGSTPEIPEHLKIT
SGTQFSEVPVGYKRSQPQNVLTYKSETYSFGQCTWYAYNRVKELGYQVDRYMGNGGDWQRKPGFVTTHKPKVGYVVSFAP
GQAGADATYGHVAVVEQIKEDGSILISESNVMGLGTISYRTFTAEQASLLTYVVGDKLPRP

Sequences:

>Translated_541_residues
MKKRKLLAVTLLSTILLNSAVPLVVADTSLRNSTSSTDQPTTADTDTDDESETPKKDKKSKETASQHDTQKDHKPSHTHP
TPPSNDTKQTDQASSEATDKPNKDKNDTKQPDSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKT
PEKGPEKATDKTPEPNRDAPKPIQPPLAAAPVFIPWRESDKDLSKLKPSSRSSAAYVRHWTGDSAYTHNLLSRRYGITAE
QLDGFLNSLGIHYDKERLNGKRLLEWEKLTGLDVRAIVAIAMAESSLGTQGVAKEKGANMFGYGAFDFNPNNAKKYSDEV
AIRHMVEDTIIANKNQTFERQDLKAKKWSLGQLDTLIDGGVYFTDTSGSGQRRADIMTKLDQWIDDHGSTPEIPEHLKIT
SGTQFSEVPVGYKRSQPQNVLTYKSETYSFGQCTWYAYNRVKELGYQVDRYMGNGGDWQRKPGFVTTHKPKVGYVVSFAP
GQAGADATYGHVAVVEQIKEDGSILISESNVMGLGTISYRTFTAEQASLLTYVVGDKLPRP
>Mature_541_residues
MKKRKLLAVTLLSTILLNSAVPLVVADTSLRNSTSSTDQPTTADTDTDDESETPKKDKKSKETASQHDTQKDHKPSHTHP
TPPSNDTKQTDQASSEATDKPNKDKNDTKQPDSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKT
PEKGPEKATDKTPEPNRDAPKPIQPPLAAAPVFIPWRESDKDLSKLKPSSRSSAAYVRHWTGDSAYTHNLLSRRYGITAE
QLDGFLNSLGIHYDKERLNGKRLLEWEKLTGLDVRAIVAIAMAESSLGTQGVAKEKGANMFGYGAFDFNPNNAKKYSDEV
AIRHMVEDTIIANKNQTFERQDLKAKKWSLGQLDTLIDGGVYFTDTSGSGQRRADIMTKLDQWIDDHGSTPEIPEHLKIT
SGTQFSEVPVGYKRSQPQNVLTYKSETYSFGQCTWYAYNRVKELGYQVDRYMGNGGDWQRKPGFVTTHKPKVGYVVSFAP
GQAGADATYGHVAVVEQIKEDGSILISESNVMGLGTISYRTFTAEQASLLTYVVGDKLPRP

Specific function: Peptidoglycan hydrolase involved in the splitting of the septum during cell division [H]

COG id: COG3942

COG function: function code R; Surface antigen

Gene ontology:

Cell location: Secreted. Cell surface (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 peptidase C51 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007921
- InterPro:   IPR018392
- InterPro:   IPR002482 [H]

Pfam domain/function: PF05257 CHAP; PF01476 LysM [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 59801; Mature: 59801

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS50911 CHAP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRKLLAVTLLSTILLNSAVPLVVADTSLRNSTSSTDQPTTADTDTDDESETPKKDKKS
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KETASQHDTQKDHKPSHTHPTPPSNDTKQTDQASSEATDKPNKDKNDTKQPDSSDQSTPS
HHHHHHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKTPEKGPEKATDKTPEPNRDAP
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KPIQPPLAAAPVFIPWRESDKDLSKLKPSSRSSAAYVRHWTGDSAYTHNLLSRRYGITAE
CCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
QLDGFLNSLGIHYDKERLNGKRLLEWEKLTGLDVRAIVAIAMAESSLGTQGVAKEKGANM
HHHHHHHHHCCEECHHHCCCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCE
FGYGAFDFNPNNAKKYSDEVAIRHMVEDTIIANKNQTFERQDLKAKKWSLGQLDTLIDGG
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHCCCCHHHHHHCCC
VYFTDTSGSGQRRADIMTKLDQWIDDHGSTPEIPEHLKITSGTQFSEVPVGYKRSQPQNV
EEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCE
LTYKSETYSFGQCTWYAYNRVKELGYQVDRYMGNGGDWQRKPGFVTTHKPKVGYVVSFAP
EEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECC
GQAGADATYGHVAVVEQIKEDGSILISESNVMGLGTISYRTFTAEQASLLTYVVGDKLPR
CCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEEEEEEEEECCHHHHHHHHHHCCCCCC
P
C
>Mature Secondary Structure
MKKRKLLAVTLLSTILLNSAVPLVVADTSLRNSTSSTDQPTTADTDTDDESETPKKDKKS
CCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
KETASQHDTQKDHKPSHTHPTPPSNDTKQTDQASSEATDKPNKDKNDTKQPDSSDQSTPS
HHHHHHHCCHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
PKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKTPEKGPEKATDKTPEPNRDAP
CCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
KPIQPPLAAAPVFIPWRESDKDLSKLKPSSRSSAAYVRHWTGDSAYTHNLLSRRYGITAE
CCCCCCCCCCCEEEECCCCCCHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHH
QLDGFLNSLGIHYDKERLNGKRLLEWEKLTGLDVRAIVAIAMAESSLGTQGVAKEKGANM
HHHHHHHHHCCEECHHHCCCCCEEEHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCE
FGYGAFDFNPNNAKKYSDEVAIRHMVEDTIIANKNQTFERQDLKAKKWSLGQLDTLIDGG
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHCCCCHHHHHHCCC
VYFTDTSGSGQRRADIMTKLDQWIDDHGSTPEIPEHLKITSGTQFSEVPVGYKRSQPQNV
EEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCE
LTYKSETYSFGQCTWYAYNRVKELGYQVDRYMGNGGDWQRKPGFVTTHKPKVGYVVSFAP
EEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEEEECC
GQAGADATYGHVAVVEQIKEDGSILISESNVMGLGTISYRTFTAEQASLLTYVVGDKLPR
CCCCCCCCCHHHHHHHHHHCCCCEEEECCCEEEEEEEEEEEECCHHHHHHHHHHCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA