Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is dppE [H]

Identifier: 15675791

GI number: 15675791

Start: 1670951

End: 1671577

Strand: Direct

Name: dppE [H]

Synonym: SPy_2004

Alternate gene names: 15675791

Gene position: 1670951-1671577 (Clockwise)

Preceding gene: 15675790

Following gene: 15675797

Centisome position: 90.2

GC content: 38.28

Gene sequence:

>627_bases
ATGACCTTAGAGGCTAAAAAGCTTGGCTTTTATCATAAAAAAGATCAATGGCTTTTTAAGGAGATTGATTTAGAGGTAGC
ACCTGGTCAAATCTTAGGGATATTTGGACAAAGTGGGTGTGGAAAAACGAGTTTATCCAGAGTGCTTGCTGGTTTTTTGC
AGCCTAAATCTGGTGAAGTATTAGTTGATGGCAGTCATTTGCCTAACAAAGCATTTAGACCTGTACAACTTATCCAACAA
CATCCTGAACAAACCATGAATCCTTTATGGCCTATGAAAAAAAGTTTGGAAGAAGCCTACTATCCAAGTCAAGATTTGCG
AGATGCTTTTGGCATTCAAGAAAAATGGCTAAAGCGTCGTCCTAGTGAACTCTCGGGAGGGGAATTGCAACGCTTTTCGA
TTGTGCGTTCATTACATCCAGAGACGAAATACCTTATTGCAGATGAAATGACTACTATGTTGGATAGCATTACACAAGCT
AGTGTATGGAAAAGCCTGTTGGAGATTGTAAAGGATAGAAATTTAGGTCTCATCATTATTAGTCATGAGTTTGATATGTT
AGAAAAACTTTGTGACGCGTGCTATATGATTGAAGAGAATCGTACTCAACTGTTCAAGCATACCTAA

Upstream 100 bases:

>100_bases
GCTAGCTTTTTTAGCGGAGGTGGGGAGCAATTACAAACAGAATTTGCGAGACGTTTATGGCGCACACTCCCTCAGCAAGA
CTTTTTGAAAGGAGTTACTC

Downstream 100 bases:

>100_bases
CACCTACGGTTATTACCTATTGAGTCTTTTCCTAACAAAATCACACCATTAAAAAAACCAGCTTACAGCTGGTTTTTTAA
TTATTTTAATTTTTCCTTAA

Product: ATPase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEVLVDGSHLPNKAFRPVQLIQQ
HPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLKRRPSELSGGELQRFSIVRSLHPETKYLIADEMTTMLDSITQA
SVWKSLLEIVKDRNLGLIIISHEFDMLEKLCDACYMIEENRTQLFKHT

Sequences:

>Translated_208_residues
MTLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEVLVDGSHLPNKAFRPVQLIQQ
HPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLKRRPSELSGGELQRFSIVRSLHPETKYLIADEMTTMLDSITQA
SVWKSLLEIVKDRNLGLIIISHEFDMLEKLCDACYMIEENRTQLFKHT
>Mature_207_residues
TLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEVLVDGSHLPNKAFRPVQLIQQH
PEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLKRRPSELSGGELQRFSIVRSLHPETKYLIADEMTTMLDSITQAS
VWKSLLEIVKDRNLGLIIISHEFDMLEKLCDACYMIEENRTQLFKHT

Specific function: Part of a transport system that may be involved in oligopeptide uptake. Probably responsible for energy coupling to the transport system. Important for S.aureus growth and survival during the infection process [H]

COG id: COG1124

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=212, Percent_Identity=28.3018867924528, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI153792144, Length=210, Percent_Identity=26.1904761904762, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI116734710, Length=205, Percent_Identity=24.390243902439, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1787758, Length=213, Percent_Identity=31.4553990610329, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1786398, Length=216, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1789891, Length=213, Percent_Identity=29.1079812206573, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1789890, Length=203, Percent_Identity=29.064039408867, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1787500, Length=191, Percent_Identity=30.8900523560209, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1788506, Length=230, Percent_Identity=29.5652173913043, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87081791, Length=179, Percent_Identity=29.608938547486, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI48994883, Length=213, Percent_Identity=29.1079812206573, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1787547, Length=210, Percent_Identity=24.2857142857143, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI145693107, Length=192, Percent_Identity=27.0833333333333, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1789962, Length=183, Percent_Identity=27.8688524590164, Blast_Score=79, Evalue=1e-16,
Organism=Escherichia coli, GI1786698, Length=195, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787029, Length=201, Percent_Identity=29.3532338308458, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI87081834, Length=190, Percent_Identity=27.8947368421053, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI48994997, Length=209, Percent_Identity=24.8803827751196, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789963, Length=215, Percent_Identity=28.8372093023256, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1788225, Length=208, Percent_Identity=25.4807692307692, Blast_Score=74, Evalue=5e-15,
Organism=Escherichia coli, GI1789751, Length=197, Percent_Identity=28.4263959390863, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1787164, Length=211, Percent_Identity=23.696682464455, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786319, Length=193, Percent_Identity=29.0155440414508, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786703, Length=204, Percent_Identity=27.4509803921569, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787759, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1787112, Length=205, Percent_Identity=28.2926829268293, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786253, Length=203, Percent_Identity=25.615763546798, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787370, Length=196, Percent_Identity=23.9795918367347, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI87081709, Length=184, Percent_Identity=23.9130434782609, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786345, Length=195, Percent_Identity=26.6666666666667, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789672, Length=192, Percent_Identity=25.5208333333333, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1787548, Length=216, Percent_Identity=23.1481481481481, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1786803, Length=190, Percent_Identity=27.3684210526316, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71984940, Length=208, Percent_Identity=29.3269230769231, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565938, Length=224, Percent_Identity=25.4464285714286, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17541710, Length=212, Percent_Identity=27.8301886792453, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71992290, Length=212, Percent_Identity=27.8301886792453, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17543740, Length=203, Percent_Identity=26.1083743842365, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558664, Length=204, Percent_Identity=27.4509803921569, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115534520, Length=214, Percent_Identity=25.2336448598131, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193208177, Length=209, Percent_Identity=25.3588516746411, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71996550, Length=218, Percent_Identity=25.6880733944954, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI193202349, Length=194, Percent_Identity=26.8041237113402, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666092, Length=197, Percent_Identity=28.9340101522843, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357907, Length=209, Percent_Identity=24.8803827751196, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 23895; Mature: 23764

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MTLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEV
CCCCCHHCCCCCCCCCHHHHHHCCEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCE
LVDGSHLPNKAFRPVQLIQQHPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLKRR
EEECCCCCCCCCHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCHHHHHHHCC
PSELSGGELQRFSIVRSLHPETKYLIADEMTTMLDSITQASVWKSLLEIVKDRNLGLIII
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SHEFDMLEKLCDACYMIEENRTQLFKHT
ECCHHHHHHHHHHHHHHHCCHHHHHCCC
>Mature Secondary Structure 
TLEAKKLGFYHKKDQWLFKEIDLEVAPGQILGIFGQSGCGKTSLSRVLAGFLQPKSGEV
CCCCHHCCCCCCCCCHHHHHHCCEECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCE
LVDGSHLPNKAFRPVQLIQQHPEQTMNPLWPMKKSLEEAYYPSQDLRDAFGIQEKWLKRR
EEECCCCCCCCCHHHHHHHHCHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCHHHHHHHCC
PSELSGGELQRFSIVRSLHPETKYLIADEMTTMLDSITQASVWKSLLEIVKDRNLGLIII
CCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
SHEFDMLEKLCDACYMIEENRTQLFKHT
ECCHHHHHHHHHHHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA