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The map label for this gene is fba

Identifier: 15675705

GI number: 15675705

Start: 1567024

End: 1567905

Strand: Reverse

Name: fba

Synonym: SPy_1889

Alternate gene names: 15675705

Gene position: 1567905-1567024 (Counterclockwise)

Preceding gene: 15675706

Following gene: 15675704

Centisome position: 84.64

GC content: 41.72

Gene sequence:

>882_bases
ATGGCAATCGTTTCAGCAGAAAAATTTGTCCAAGCAGCTCGTGAAAACGGATATGCTGTTGGTGGATTTAACACAAACAA
CTTAGAGTGGACTCAAGCAATCTTGCGTGCAGCAGAAGCTAAACAAGCTCCAGTTCTTATCCAAACATCAATGGGTGCAG
CAAAATACATGGGTGGTTATAAAGTATGTCAATCTCTTATTACTAACCTTGTTGAGTCAATGGGTATCACTGTTCCTGTT
GCTATCCACCTTGATCATGGTCACTACGAAGATGCTCTTGAGTGTATCGAAGTAGGTTACACTTCAATCATGTTTGACGG
TTCACACCTTCCAGTTGAAGAAAACCTTGCTAAAACTGCAGAAGTTGTTAAAATTGCACATGCTAAAGGCGTTTCAGTTG
AAGCTGAAGTTGGTACAATCGGTGGTGAAGAAGACGGTATCATCGGTAAAGGTGAGCTCGCTCCAATCGAAGATGCTAAA
GCAATGGTTGAAACTGGAATTGACTTCTTGGCAGCTGGTATCGGTAACATCCACGGTCCATACCCAGAAAACTGGGAAGG
TCTTGCTCTTGACCACTTAGAAAAATTAACAGCAGCTGTACCAGGTTTCCCAATCGTATTGCACGGTGGTTCTGGTATTC
CTGACGATCAAATCAAAGAAGCAATCCGTCTTGGTGTTGCTAAAGTTAATGTTAACACTGAAAGTCAAATCGCTTTCTCT
AACGCAACTCGTGAATTTGCTCGTAACTACGAAGCTAACGAAGCAGAATATGATGGTAAAAAATTATTTGACCCACGTAA
ATTCTTGGCTCCAGGTATGAAAGCTGTTCAAGGTGCTGTTGAAGAACGTATCGATGTTTTCGGATCAGCTAACAAAGCAT
AA

Upstream 100 bases:

>100_bases
CGCTTTAAGCTTGTGAAAGGCTAGAAATTTATGGAAAATTGTGCTAGAATGAACAATGTAAACGGGGAGTTATCCCGAAA
AATAAGAGGAGGCCTTACAA

Downstream 100 bases:

>100_bases
TTTAGAGTATTAAACACCCTAAAGCCCTCTTGAGGGCTTTTTTAGATATAATTGACACCCTAAAATGGATACCAGTTTCT
GTGAAATAATCTTTGATTGT

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPV
AIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAK
AMVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFS
NATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA

Sequences:

>Translated_293_residues
MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPV
AIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAK
AMVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFS
NATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA
>Mature_292_residues
AIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGYKVCQSLITNLVESMGITVPVA
IHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTAEVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAKA
MVETGIDFLAAGIGNIHGPYPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFSN
ATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family

Homologues:

Organism=Escherichia coli, GI1789526, Length=301, Percent_Identity=37.5415282392027, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082041, Length=300, Percent_Identity=35.3333333333333, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1788072, Length=290, Percent_Identity=34.8275862068965, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1789293, Length=342, Percent_Identity=26.3157894736842, Blast_Score=90, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322790, Length=341, Percent_Identity=27.2727272727273, Blast_Score=91, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALF_STRP1 (P68905)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269879.1
- RefSeq:   YP_282970.1
- ProteinModelPortal:   P68905
- SMR:   P68905
- EnsemblBacteria:   EBSTRT00000001088
- EnsemblBacteria:   EBSTRT00000027793
- GeneID:   3571297
- GeneID:   902096
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1889
- KEGG:   spz:M5005_Spy_1607
- GeneTree:   EBGT00050000027845
- HOGENOM:   HBG327581
- OMA:   EYEANEA
- ProtClustDB:   PRK07315
- BioCyc:   SPYO160490:SPY1889-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1607-MONOMER
- GO:   GO:0006096
- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF001359
- TIGRFAMs:   TIGR00167
- TIGRFAMs:   TIGR01859

Pfam domain/function: PF01116 F_bP_aldolase

EC number: =4.1.2.13

Molecular weight: Translated: 31209; Mature: 31077

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00602 ALDOLASE_CLASS_II_1; PS00806 ALDOLASE_CLASS_II_2

Important sites: ACT_SITE 85-85 BINDING 50-50 BINDING 179-179

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGY
CCCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHH
KVCQSLITNLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTA
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
EVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGP
HHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFS
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHEEECCCCHHEEHH
NATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AIVSAEKFVQAARENGYAVGGFNTNNLEWTQAILRAAEAKQAPVLIQTSMGAAKYMGGY
CCCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHH
KVCQSLITNLVESMGITVPVAIHLDHGHYEDALECIEVGYTSIMFDGSHLPVEENLAKTA
HHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHH
EVVKIAHAKGVSVEAEVGTIGGEEDGIIGKGELAPIEDAKAMVETGIDFLAAGIGNIHGP
HHHHHHHCCCCEEEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
YPENWEGLALDHLEKLTAAVPGFPIVLHGGSGIPDDQIKEAIRLGVAKVNVNTESQIAFS
CCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHEEECCCCHHEEHH
NATREFARNYEANEAEYDGKKLFDPRKFLAPGMKAVQGAVEERIDVFGSANKA
HHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296