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The map label for this gene is mutS2 [H]

Identifier: 15675664

GI number: 15675664

Start: 1523305

End: 1525644

Strand: Reverse

Name: mutS2 [H]

Synonym: SPy_1837

Alternate gene names: 15675664

Gene position: 1525644-1523305 (Counterclockwise)

Preceding gene: 15675665

Following gene: 15675663

Centisome position: 82.36

GC content: 36.79

Gene sequence:

>2340_bases
ATGAATAACAAGATTTTAGAGCAGTTAGAATTTAACAAAGTTAAGGAATTGCTATTACCTTATCTCAAGACAGAACAATC
ACAAGAAGAATTATTAGAGCTGGAGCCGATGACGGAGGCTCCTAAAATAGAAAAAAGTTTTAATGAAATTTCTGACATGG
AACAGATTTTTGTTGAACATCACTCATTTGGCATAGTCAGCCTAAGTTCAATCTCTGAGAGTTTAAAACGCTTAGAGCTT
TCAACTGATCTTAATATTCAAGAACTTTTGGCTATCAAAAAAGTTTTACAGAGTTCTTCGGATATGATTCACTTTTATTC
TGATTTGGATAATGTTTCTTTCCAATCTTTGGATCGTTTGTTTGAAAATTTGGAACAATTCCCTAATCTGCAAGGGTCTT
TTCAAGCTATCAATGATGGTGGTTTTTTAGAACATTTTGCGAGTCCAGAATTAGAGCGTATCCGTCGTCAATTAACAAAT
AGTGAACGACGGGTTCGTCAGATTTTACAGGATATGCTTAAGGAAAAAGCAGAGCTTTTATCAGAGAATCTAATCGCTAG
TCGTAGTGGACGAAGTGTCCTACCAGTAAAAAATACTTATCGGAATCGTATTTCTGGTGTGGTTCATGACATCTCTTCTT
CAGGAAGTACTGTTTATATTGAGCCTCGTGCTGTAGTTACACTAAACGAAGAGATAACGCAGCTTAGAGCTGACGAACGC
CACGAAGAAGGTCGTATTTTACACGCATTTTCAGACTTGTTAAGACCTCATGTCGCCACTATTAGAAATAATGCATGGAT
TCTTGGGCATCTTGATTTTGTAAGGGCTAAATATCTTTTTATGTCTGATAATAAGGCGACGATACCTAAGATTTCTAATG
ACAGCACGTTAGCATTAATCAATGTTCGTCATCCTCTGTTAAGTAATCCTGTGGCTAATGACTTACATTTTGATCACGAT
TTAACTGCAATTGTCATCACTGGTCCCAATACTGGTGGTAAGACGATTATGCTAAAAACACTCGGTTTAGCACAATTAAT
GGGACAGTCTGGTTTGCCAGTATTAGCGGATAAAGGTAGTAAAATTGCAGTATTTAACAATATCTTTGCAGATATTGGCG
ATGAGCAATCTATTGAACAAAGTCTATCAACTTTTTCTAGTCATATGACGCACATAGTCAGTATTTTAAACGAGGCTGAC
CACAATAGTTTAGTTCTCTTTGATGAACTAGGAGCAGGAACGGATCCTCAAGAAGGTGCTAGTTTGGCCATGGCTATTTT
AGAACACCTTAGGTTAAGTCATATCAAAACGATGGCGACCACGCACTATCCAGAATTAAAAGCTTATGGGATTGAGACAA
ATTTTGTAGAGAATGCGAGCATGGAATTTGATGCAGAAACGCTTAGCCCCACATATCGCTTTATGCAAGGAGTTCCTGGA
CGCTCAAATGCATTTGAAATTGCTTCTCGCCTTGGTTTAGCTCCATTTATTGTTAAACAAGCTAAGCAGATGACAGATTC
TGACTCAGATGTTAACCGTATTATTGAACAGTTAGAGGCACAGACACTTGAGACACGTAGAAGACTGGATCATATTAAAG
AAGTTGAACAAGAAAACCTCAAATTCAATCGTGCGGTTAAGAAACTCTATAATGAATTTTCACATGAACGCGATAAAGAG
TTAGAAAAAATCTATCAAGAAGCTCAAGAAATTGTAGATATGGCTTTGAATGAGAGTGATACTATCTTAAAAAAACTCAA
TGATAAGAGCCAATTAAAACCTCACGAAATTATAGATGCTAAGGCACAAATAAAAAAATTAGCACCTCAAGTTGATTTAT
CAAAAAATAAAGTCTTAAATAAGGCTAAAAAAATCAAAGCAGCTCGTGCCCCTAGAATTGGTGATGATATTATAGTGACT
AGTTATGGACAGCGAGGTACCTTAACTAGTCAATTAAAAGATGGCCGTTGGGAAGCACAAGTGGGAATTATCAAAATGAC
ATTAACACAAGATGAATTTAGCCTCGTTAGAGTCCAAGAAGAACAGAAAGTCAAAAATAAACAGATTAATGTGGTTAAAA
AGGCTGATGGTTCTGGACCAAGAGCTCGACTTGATCTTAGAGGTAAAAGATACGAAGAAGCAATGCAAGAGTTAGATCAT
TTTATTGATCAAGCATTGCTTAACAATATGGGACAAGTTGATATCATTCATGGTATTGGTACAGGCGTTATTCGTGAGGG
AGTGACAAAATATCTTCGTCGTAATAAGCATGTTAAGCATTTTGCTTATGCCCCACAAAATGCAGGGGGATCTGGTGCCA
CAATTGTAACGTTAGGGTAA

Upstream 100 bases:

>100_bases
GTTCTTTATTTACGAGAAACTGTTTAGAAATAAAGAGAACGCATGGGAACTTAGTGACTTTCTTGCCCCATTTTCCATCA
TTTTAGGTATAATGAAGAGT

Downstream 100 bases:

>100_bases
ATGATGGAATCATATGAACACTTTTATGCCAAACTATCTCAACCTTTTAGAAAAACCCCACAGTTAATAATTCTTTTAAA
TGTTTTACTAAAAATAATCA

Product: putative DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 779; Mature: 779

Protein sequence:

>779_residues
MNNKILEQLEFNKVKELLLPYLKTEQSQEELLELEPMTEAPKIEKSFNEISDMEQIFVEHHSFGIVSLSSISESLKRLEL
STDLNIQELLAIKKVLQSSSDMIHFYSDLDNVSFQSLDRLFENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTN
SERRVRQILQDMLKEKAELLSENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADER
HEEGRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPKISNDSTLALINVRHPLLSNPVANDLHFDHD
LTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGSKIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEAD
HNSLVLFDELGAGTDPQEGASLAMAILEHLRLSHIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPG
RSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEVEQENLKFNRAVKKLYNEFSHERDKE
LEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDAKAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVT
SYGQRGTLTSQLKDGRWEAQVGIIKMTLTQDEFSLVRVQEEQKVKNKQINVVKKADGSGPRARLDLRGKRYEEAMQELDH
FIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG

Sequences:

>Translated_779_residues
MNNKILEQLEFNKVKELLLPYLKTEQSQEELLELEPMTEAPKIEKSFNEISDMEQIFVEHHSFGIVSLSSISESLKRLEL
STDLNIQELLAIKKVLQSSSDMIHFYSDLDNVSFQSLDRLFENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTN
SERRVRQILQDMLKEKAELLSENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADER
HEEGRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPKISNDSTLALINVRHPLLSNPVANDLHFDHD
LTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGSKIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEAD
HNSLVLFDELGAGTDPQEGASLAMAILEHLRLSHIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPG
RSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEVEQENLKFNRAVKKLYNEFSHERDKE
LEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDAKAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVT
SYGQRGTLTSQLKDGRWEAQVGIIKMTLTQDEFSLVRVQEEQKVKNKQINVVKKADGSGPRARLDLRGKRYEEAMQELDH
FIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG
>Mature_779_residues
MNNKILEQLEFNKVKELLLPYLKTEQSQEELLELEPMTEAPKIEKSFNEISDMEQIFVEHHSFGIVSLSSISESLKRLEL
STDLNIQELLAIKKVLQSSSDMIHFYSDLDNVSFQSLDRLFENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTN
SERRVRQILQDMLKEKAELLSENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADER
HEEGRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPKISNDSTLALINVRHPLLSNPVANDLHFDHD
LTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGSKIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEAD
HNSLVLFDELGAGTDPQEGASLAMAILEHLRLSHIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPG
RSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEVEQENLKFNRAVKKLYNEFSHERDKE
LEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDAKAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVT
SYGQRGTLTSQLKDGRWEAQVGIIKMTLTQDEFSLVRVQEEQKVKNKQINVVKKADGSGPRARLDLRGKRYEEAMQELDH
FIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=252, Percent_Identity=32.9365079365079, Blast_Score=108, Evalue=3e-23,
Organism=Homo sapiens, GI284813531, Length=242, Percent_Identity=29.7520661157025, Blast_Score=94, Evalue=7e-19,
Organism=Homo sapiens, GI4557761, Length=318, Percent_Identity=26.7295597484277, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI4504191, Length=223, Percent_Identity=29.5964125560538, Blast_Score=91, Evalue=5e-18,
Organism=Homo sapiens, GI26638666, Length=220, Percent_Identity=32.2727272727273, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4505253, Length=220, Percent_Identity=32.2727272727273, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI26638664, Length=221, Percent_Identity=32.1266968325792, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI262231786, Length=135, Percent_Identity=37.7777777777778, Blast_Score=71, Evalue=5e-12,
Organism=Escherichia coli, GI1789089, Length=277, Percent_Identity=31.7689530685921, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17534743, Length=254, Percent_Identity=27.1653543307087, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508445, Length=372, Percent_Identity=23.9247311827957, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=292, Percent_Identity=25.6849315068493, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321912, Length=318, Percent_Identity=24.8427672955975, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324482, Length=407, Percent_Identity=25.0614250614251, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6321109, Length=200, Percent_Identity=29, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319935, Length=221, Percent_Identity=27.6018099547511, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320047, Length=299, Percent_Identity=25.0836120401338, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320302, Length=235, Percent_Identity=25.1063829787234, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24584320, Length=251, Percent_Identity=29.8804780876494, Blast_Score=103, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24664545, Length=236, Percent_Identity=27.5423728813559, Blast_Score=86, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 87805; Mature: 87805

Theoretical pI: Translated: 6.49; Mature: 6.49

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKILEQLEFNKVKELLLPYLKTEQSQEELLELEPMTEAPKIEKSFNEISDMEQIFVEH
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
HSFGIVSLSSISESLKRLELSTDLNIQELLAIKKVLQSSSDMIHFYSDLDNVSFQSLDRL
HCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHH
FENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTNSERRVRQILQDMLKEKAELL
HHHHHHCCCCCCCCEEECCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADER
HHHHHHCCCCCEECCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECHHHHHHHHHCC
HEEGRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPKISNDSTLALI
HHCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHEEEEEECCCCCCCCCCCCCEEEEE
NVRHPLLSNPVANDLHFDHDLTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGS
EECCCHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHCCCCCCEEECCCC
KIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEADHNSLVLFDELGAGTDPQEGA
EEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHH
SLAMAILEHLRLSHIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPG
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCHHHCCHHHHHHHCCCC
RSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEVEQENL
CCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFNRAVKKLYNEFSHERDKELEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHH
KAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVTSYGQRGTLTSQLKDGRWEAQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHCCCCEEEE
VGIIKMTLTQDEFSLVRVQEEQKVKNKQINVVKKADGSGPRARLDLRGKRYEEAMQELDH
EEEEEEEEECCCHHHHEECHHHHHCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHH
FIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG
HHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure
MNNKILEQLEFNKVKELLLPYLKTEQSQEELLELEPMTEAPKIEKSFNEISDMEQIFVEH
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
HSFGIVSLSSISESLKRLELSTDLNIQELLAIKKVLQSSSDMIHFYSDLDNVSFQSLDRL
HCCCEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEHHCCCCCCHHHHHHH
FENLEQFPNLQGSFQAINDGGFLEHFASPELERIRRQLTNSERRVRQILQDMLKEKAELL
HHHHHHCCCCCCCCEEECCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SENLIASRSGRSVLPVKNTYRNRISGVVHDISSSGSTVYIEPRAVVTLNEEITQLRADER
HHHHHHCCCCCEECCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEECHHHHHHHHHCC
HEEGRILHAFSDLLRPHVATIRNNAWILGHLDFVRAKYLFMSDNKATIPKISNDSTLALI
HHCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHEEEEEECCCCCCCCCCCCCEEEEE
NVRHPLLSNPVANDLHFDHDLTAIVITGPNTGGKTIMLKTLGLAQLMGQSGLPVLADKGS
EECCCHHCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHCCCCCCEEECCCC
KIAVFNNIFADIGDEQSIEQSLSTFSSHMTHIVSILNEADHNSLVLFDELGAGTDPQEGA
EEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHH
SLAMAILEHLRLSHIKTMATTHYPELKAYGIETNFVENASMEFDAETLSPTYRFMQGVPG
HHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCHHHCCHHHHHHHCCCC
RSNAFEIASRLGLAPFIVKQAKQMTDSDSDVNRIIEQLEAQTLETRRRLDHIKEVEQENL
CCHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFNRAVKKLYNEFSHERDKELEKIYQEAQEIVDMALNESDTILKKLNDKSQLKPHEIIDA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHH
KAQIKKLAPQVDLSKNKVLNKAKKIKAARAPRIGDDIIVTSYGQRGTLTSQLKDGRWEAQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHCCCCEEEE
VGIIKMTLTQDEFSLVRVQEEQKVKNKQINVVKKADGSGPRARLDLRGKRYEEAMQELDH
EEEEEEEEECCCHHHHEECHHHHHCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHH
FIDQALLNNMGQVDIIHGIGTGVIREGVTKYLRRNKHVKHFAYAPQNAGGSGATIVTLG
HHHHHHHCCCCCEEEEHHCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA