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The map label for this gene is pepP [H]

Identifier: 15675652

GI number: 15675652

Start: 1512611

End: 1513684

Strand: Reverse

Name: pepP [H]

Synonym: SPy_1824

Alternate gene names: 15675652

Gene position: 1513684-1512611 (Counterclockwise)

Preceding gene: 15675653

Following gene: 15675651

Centisome position: 81.71

GC content: 43.11

Gene sequence:

>1074_bases
ATGTCAGGATTTTTAGAACAACGATTAGGTCACTGCCTAAGGCAGATGGCAGAGAAGGGGCTAGAGGCTCTTCTAGTCAC
CCATTTAACCAATAGTTATTACTTGACAGGTTTTTCTGGAACTGCAGCAACTGTTTTGATAACGGCCAAACGTCGTGTTT
TGATCACAGATTCACGTTATACCTTGCTTGCTAAAGCTAGTGTTGAGGGATTTGATATTATCGAAAGCCGCACGCCGCTT
AAGGTTGTGGCAGAATTGTTAGAGGCTGATCAAATAGATTGCCTTGGTTTTGAGGACCAGGTATCGTTTTCTTTTTACCA
GGCCATGCAAGCAGAACTGTCAGGAATAACCTTGCTTGCTCAGTCAGGTTTTGTGGAGCATTTACGTCTTATTAAGGACG
CCTCTGAAATCGATACCATTGCTAAAGCGTGCTCGATCTCAGACAAAGCATTTGAAGATGCTCTTGATTTTATTAAACCA
GGGACAACCACTGAACGTGACCTGGCTAATTTTTTAGATTTTCGTATGCGTCAGTATGGTGCCAGCGGCACATCATTTGA
TATCATTGTAGCTTCAGGCTATCTCTCTGCCATGCCTCATGGACGCGCCAGTGACAAGGTTATCCAGAATAAAGAGAGCT
TGACCATGGACTTTGGGTGTTACTACAATCACTATGTTAGTGATATGACGAGGACCATTCATATTGGCCAAGTTACTGAT
GAAGAACGTGAGATTTATGCTCTTGTTCTTGCTGCTAATAAGGCTTTAATTGCTAAAGCTAGCGCTGGCATGACTTATAG
TGACTTTGACGGTATTCCGCGCCAACTCATCACTGAGGCGGGTTATGGCAGTCGCTTCACACATGGCATTGGTCATGGCA
TCGGGCTTGACATCCATGAGAATCCATTTTTTGGGAAATCTGAGCAACTTCTCCAAGCTGGAATGGTGGTAACAGATGAG
CCAGGTATCTATTTGGATAACAAATATGGTGTCCGTATTGAAGATGACTTGGTTATCACAAAAACTGGTTGTCAAGTCTT
GACCTTGGCACCCAAAGAATTAATTGTATTGTAA

Upstream 100 bases:

>100_bases
TTGAGCTCCTTTTAATCTTTTAAATGCTCTCAAATCATGGTAAACTTAAAGTAGTTTTTTCATGCTACAATATTCTCAAA
AGTTACCAAAGGAGTTCGCG

Downstream 100 bases:

>100_bases
AAGAATGGTTCAGGAAAGGATTAGGGGAGAAGCAATGACAAATCGTTTATCATGGCAAGACTATTTTATGGCCAATGCAG
AGCTGATTTCCAAGCGCTCT

Product: Xaa-Pro dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDIIESRTPL
KVVAELLEADQIDCLGFEDQVSFSFYQAMQAELSGITLLAQSGFVEHLRLIKDASEIDTIAKACSISDKAFEDALDFIKP
GTTTERDLANFLDFRMRQYGASGTSFDIIVASGYLSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
EEREIYALVLAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSRFTHGIGHGIGLDIHENPFFGKSEQLLQAGMVVTDE
PGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL

Sequences:

>Translated_357_residues
MSGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDIIESRTPL
KVVAELLEADQIDCLGFEDQVSFSFYQAMQAELSGITLLAQSGFVEHLRLIKDASEIDTIAKACSISDKAFEDALDFIKP
GTTTERDLANFLDFRMRQYGASGTSFDIIVASGYLSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
EEREIYALVLAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSRFTHGIGHGIGLDIHENPFFGKSEQLLQAGMVVTDE
PGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL
>Mature_356_residues
SGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRYTLLAKASVEGFDIIESRTPLK
VVAELLEADQIDCLGFEDQVSFSFYQAMQAELSGITLLAQSGFVEHLRLIKDASEIDTIAKACSISDKAFEDALDFIKPG
TTTERDLANFLDFRMRQYGASGTSFDIIVASGYLSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTDE
EREIYALVLAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSRFTHGIGHGIGLDIHENPFFGKSEQLLQAGMVVTDEP
GIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=260, Percent_Identity=30.7692307692308, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI93141226, Length=189, Percent_Identity=32.8042328042328, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI264681563, Length=177, Percent_Identity=32.2033898305085, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI260593665, Length=311, Percent_Identity=24.1157556270096, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI149589008, Length=311, Percent_Identity=24.1157556270096, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI264681565, Length=126, Percent_Identity=35.7142857142857, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788728, Length=346, Percent_Identity=37.8612716763006, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789275, Length=274, Percent_Identity=29.1970802919708, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17508215, Length=292, Percent_Identity=27.7397260273973, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71989583, Length=288, Percent_Identity=23.9583333333333, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=185, Percent_Identity=32.972972972973, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321118, Length=391, Percent_Identity=25.5754475703325, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322999, Length=183, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320922, Length=268, Percent_Identity=29.4776119402985, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19920384, Length=273, Percent_Identity=27.1062271062271, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI21357079, Length=288, Percent_Identity=27.7777777777778, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17137632, Length=171, Percent_Identity=29.8245614035088, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 39289; Mature: 39158

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCEEEEECCCE
TLLAKASVEGFDIIESRTPLKVVAELLEADQIDCLGFEDQVSFSFYQAMQAELSGITLLA
EEEEECCCCCCCHHCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
QSGFVEHLRLIKDASEIDTIAKACSISDKAFEDALDFIKPGTTTERDLANFLDFRMRQYG
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
ASGTSFDIIVASGYLSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
CCCCEEEEEEECCHHHHCCCCCCCCHHHCCCCCEEEEECHHHHHHHHHHHHEEEECCCCC
EEREIYALVLAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSRFTHGIGHGIGLDIHE
CCCEEEEEEEECCCEEEEECCCCCEEHHCCCCHHHHHHHCCCCCCHHHCCCCCCCCEECC
NPFFGKSEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL
CCCCCCHHHHHHCCCEEECCCCEEECCCCCEEEECCEEEEECCCEEEEECCHHEEEC
>Mature Secondary Structure 
SGFLEQRLGHCLRQMAEKGLEALLVTHLTNSYYLTGFSGTAATVLITAKRRVLITDSRY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEECCEEEEECCCE
TLLAKASVEGFDIIESRTPLKVVAELLEADQIDCLGFEDQVSFSFYQAMQAELSGITLLA
EEEEECCCCCCCHHCCCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEE
QSGFVEHLRLIKDASEIDTIAKACSISDKAFEDALDFIKPGTTTERDLANFLDFRMRQYG
CCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHC
ASGTSFDIIVASGYLSAMPHGRASDKVIQNKESLTMDFGCYYNHYVSDMTRTIHIGQVTD
CCCCEEEEEEECCHHHHCCCCCCCCHHHCCCCCEEEEECHHHHHHHHHHHHEEEECCCCC
EEREIYALVLAANKALIAKASAGMTYSDFDGIPRQLITEAGYGSRFTHGIGHGIGLDIHE
CCCEEEEEEEECCCEEEEECCCCCEEHHCCCCHHHHHHHCCCCCCHHHCCCCCCCCEECC
NPFFGKSEQLLQAGMVVTDEPGIYLDNKYGVRIEDDLVITKTGCQVLTLAPKELIVL
CCCCCCHHHHHHCCCEEECCCCEEECCCCCEEEECCEEEEECCCEEEEECCHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]