Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
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Accession | NC_002737 |
Length | 1,852,441 |
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The map label for this gene is grpE [H]
Identifier: 15675607
GI number: 15675607
Start: 1459341
End: 1459913
Strand: Reverse
Name: grpE [H]
Synonym: SPy_1761
Alternate gene names: 15675607
Gene position: 1459913-1459341 (Counterclockwise)
Preceding gene: 15675608
Following gene: 15675606
Centisome position: 78.81
GC content: 40.66
Gene sequence:
>573_bases ATGGCAGTATTCAATAAGTTATTTAAAAGGAGGCACTCAGTGTCAGAAGAAATTAAAAAAGACGATTTACAAGAAGAAGT GGAAGCCACTGAAACTGAAGAGACAGTTGAGGAAGTTATTGAAGAAACTCCTGAAAAATCAGAGTTAGAACTTGCAAACG AACGTGCTGATGAGTTTGAAAATAAATACTTGCGAGCTCATGCAGAAATGCAGAATATACAGCGTCGCTCTAGTGAAGAA CGTCAACAACTTCAACGCTATCGTTCTCAGGATCTGGCAAAAGCAATCTTACCATCGCTTGACAATCTAGAACGTGCCTT GGCTGTTGAAGGGTTGACAGATGATGTTAAAAAAGGTTTAGAAATGACTCGTGATAGCCTTATTCAAGCACTAAAGGAAG AAGGCGTAGAAGAAGTAGAAGTCGACTCGTTTGACCACAACTTTCATATGGCAGTTCAGACCCTCCCAGCCGATGATGAA CATCCAGCCGATAGCATTGCAGAAGTCTTTCAAAAGGGATATAAATTGCACGAGCGTCTGCTAAGACCAGCGATGGTAGT TGTTTATAACTAA
Upstream 100 bases:
>100_bases GGTCTGTTAGTTTGGTAAACATTATTGGAAAGGTATTGGCTGCTAAATTAGGTGATTATTATCGATACCTAAATTCTAAC CATTATGAAGTTCACTGATA
Downstream 100 bases:
>100_bases GGTAAATGAGTTTTCGTTTTTGTCCGTAATGACAGTAAACTAGATAGCAAGTTAGAAGCTATTTCGCTTGCTGATTAAAC TATAGTGATTGCTTAGAATT
Product: heat shock protein GrpE
Products: NA
Alternate protein names: HSP-70 cofactor [H]
Number of amino acids: Translated: 190; Mature: 189
Protein sequence:
>190_residues MAVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEE RQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDE HPADSIAEVFQKGYKLHERLLRPAMVVVYN
Sequences:
>Translated_190_residues MAVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEE RQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDE HPADSIAEVFQKGYKLHERLLRPAMVVVYN >Mature_189_residues AVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELELANERADEFENKYLRAHAEMQNIQRRSSEER QQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGLEMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEH PADSIAEVFQKGYKLHERLLRPAMVVVYN
Specific function: Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with dnaK and grpE. It is the nucleotide exchange factor for dnaK and may function as a thermosensor. Unfolded
COG id: COG0576
COG function: function code O; Molecular chaperone GrpE (heat shock protein)
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the grpE family [H]
Homologues:
Organism=Escherichia coli, GI1788967, Length=176, Percent_Identity=32.3863636363636, Blast_Score=75, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6324806, Length=178, Percent_Identity=30.8988764044944, Blast_Score=76, Evalue=4e-15, Organism=Drosophila melanogaster, GI24653432, Length=170, Percent_Identity=32.3529411764706, Blast_Score=68, Evalue=4e-12,
Paralogues:
None
Copy number: 2359 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000740 - InterPro: IPR013805 - InterPro: IPR009012 [H]
Pfam domain/function: PF01025 GrpE [H]
EC number: NA
Molecular weight: Translated: 22055; Mature: 21924
Theoretical pI: Translated: 4.40; Mature: 4.40
Prosite motif: PS01071 GRPE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 2.6 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELELANERADEFE CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH NKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH EMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPADSIAEVFQKGYKLHERL HHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH LRPAMVVVYN HHHHHHHCCC >Mature Secondary Structure AVFNKLFKRRHSVSEEIKKDDLQEEVEATETEETVEEVIEETPEKSELELANERADEFE HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH NKYLRAHAEMQNIQRRSSEERQQLQRYRSQDLAKAILPSLDNLERALAVEGLTDDVKKGL HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH EMTRDSLIQALKEEGVEEVEVDSFDHNFHMAVQTLPADDEHPADSIAEVFQKGYKLHERL HHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH LRPAMVVVYN HHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 12354221 [H]