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The map label for this gene is lacR.1 [H]

Identifier: 15675565

GI number: 15675565

Start: 1419077

End: 1419847

Strand: Direct

Name: lacR.1 [H]

Synonym: SPy_1712

Alternate gene names: 15675565

Gene position: 1419077-1419847 (Clockwise)

Preceding gene: 15675556

Following gene: 15675569

Centisome position: 76.61

GC content: 36.19

Gene sequence:

>771_bases
ATGTTAAAAAGAGAAAGACTTCTAAAAATTACCGAAATAGTCAATGAGCAAGGTATTGTTACTGTGAATGATATTATTCA
GACTTTAAACGTTTCTGATATGACAGTTCGTAGAGACTTAGATGAACTGGAAAAAGCCGGCAAATTGATCCGCATCCATG
GAGGTGCACAAAGCATTACCATGCCTAATAAAAAAGAGCGGTCAAATATTGAAAAACAAACCGTTCAAACAAAGGAAAAA
TGGGAACTAGCTTCATATGCGACACAACTAGTCAATGATGGTGAAACAATCTTTATTGGTCCAGGAACAACTTTAGAATG
TTTCGCTGAGCAGTTAAAAAATCGTCAGATTCGCATTGTGACCAATAGCCTCCCTGTCTTTAACATCCTTCAGGACAGCG
AAACCATTGACCTGATTCTTATCGGTGGTGAATACCGATCTATTACAGGAGCTTTTGTAGGGTCCCTTGCCAGTCAAAAT
ATCTCATCCTTAAAATTTGCCAAGGCTTTTATTAGCTGTAATGGTATTTATAAAAACGATATTGCAACTTATAGCGAAAC
TGAAGGAGAGATTCAAAAGCTAGCTTTTAATAATTCTATTGAAAAATACCTCTTGGTAGATAACCAAAAATTCAATGCCT
ACGACTTCTTCATTTTTTACCATTTAAACAACATTGATGCTGTTGTTACAGATTCGCAAATAACTGAGGACGTTATCGAA
CGTTATAGTCAGTTCACGCAATTATTAGTAGCCCACGAAAACAAGGAGTAA

Upstream 100 bases:

>100_bases
TATGTTTGTTTTTGTTTTGTTTATTTTGTTTTATTGAAATATGAAGGTCTATATGCTATGATAAACATAAGTAAATAAAC
TATAGAAAGGAGCCCCTTAG

Downstream 100 bases:

>100_bases
CCGTTTCATCAAGAATGGACAGCCTGTCAGTGCATCGTCCTTAAACACCTTCTGGCAAAAGTGATTTGCCCCCAGAGAGG
TGTTTTTGTTTTGCTCGGAA

Product: putative lactose phosphotransferase system repressor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLKRERLLKITEIVNEQGIVTVNDIIQTLNVSDMTVRRDLDELEKAGKLIRIHGGAQSITMPNKKERSNIEKQTVQTKEK
WELASYATQLVNDGETIFIGPGTTLECFAEQLKNRQIRIVTNSLPVFNILQDSETIDLILIGGEYRSITGAFVGSLASQN
ISSLKFAKAFISCNGIYKNDIATYSETEGEIQKLAFNNSIEKYLLVDNQKFNAYDFFIFYHLNNIDAVVTDSQITEDVIE
RYSQFTQLLVAHENKE

Sequences:

>Translated_256_residues
MLKRERLLKITEIVNEQGIVTVNDIIQTLNVSDMTVRRDLDELEKAGKLIRIHGGAQSITMPNKKERSNIEKQTVQTKEK
WELASYATQLVNDGETIFIGPGTTLECFAEQLKNRQIRIVTNSLPVFNILQDSETIDLILIGGEYRSITGAFVGSLASQN
ISSLKFAKAFISCNGIYKNDIATYSETEGEIQKLAFNNSIEKYLLVDNQKFNAYDFFIFYHLNNIDAVVTDSQITEDVIE
RYSQFTQLLVAHENKE
>Mature_256_residues
MLKRERLLKITEIVNEQGIVTVNDIIQTLNVSDMTVRRDLDELEKAGKLIRIHGGAQSITMPNKKERSNIEKQTVQTKEK
WELASYATQLVNDGETIFIGPGTTLECFAEQLKNRQIRIVTNSLPVFNILQDSETIDLILIGGEYRSITGAFVGSLASQN
ISSLKFAKAFISCNGIYKNDIATYSETEGEIQKLAFNNSIEKYLLVDNQKFNAYDFFIFYHLNNIDAVVTDSQITEDVIE
RYSQFTQLLVAHENKE

Specific function: Repressor of the lactose catabolism operon. Galactose-6- phosphate is the inducer [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=243, Percent_Identity=31.2757201646091, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI226510968, Length=239, Percent_Identity=29.2887029288703, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790635, Length=245, Percent_Identity=28.5714285714286, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1787540, Length=229, Percent_Identity=31.4410480349345, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789059, Length=238, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789519, Length=240, Percent_Identity=28.75, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082344, Length=223, Percent_Identity=28.6995515695067, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790753, Length=258, Percent_Identity=25.5813953488372, Blast_Score=85, Evalue=6e-18,
Organism=Escherichia coli, GI1789170, Length=233, Percent_Identity=27.8969957081545, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1788069, Length=233, Percent_Identity=27.8969957081545, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787063, Length=245, Percent_Identity=25.3061224489796, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 29055; Mature: 29055

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRERLLKITEIVNEQGIVTVNDIIQTLNVSDMTVRRDLDELEKAGKLIRIHGGAQSIT
CCCHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
MPNKKERSNIEKQTVQTKEKWELASYATQLVNDGETIFIGPGTTLECFAEQLKNRQIRIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEE
TNSLPVFNILQDSETIDLILIGGEYRSITGAFVGSLASQNISSLKFAKAFISCNGIYKND
ECCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEECCC
IATYSETEGEIQKLAFNNSIEKYLLVDNQKFNAYDFFIFYHLNNIDAVVTDSQITEDVIE
CCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECHHHHHHHHH
RYSQFTQLLVAHENKE
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKRERLLKITEIVNEQGIVTVNDIIQTLNVSDMTVRRDLDELEKAGKLIRIHGGAQSIT
CCCHHHHHHHHHHHCCCCCEEHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCC
MPNKKERSNIEKQTVQTKEKWELASYATQLVNDGETIFIGPGTTLECFAEQLKNRQIRIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEE
TNSLPVFNILQDSETIDLILIGGEYRSITGAFVGSLASQNISSLKFAKAFISCNGIYKND
ECCCCEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEECCC
IATYSETEGEIQKLAFNNSIEKYLLVDNQKFNAYDFFIFYHLNNIDAVVTDSQITEDVIE
CCCCCCCHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEEEEECCCEEEEECHHHHHHHHH
RYSQFTQLLVAHENKE
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2120234; 1901863 [H]