Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is glpK

Identifier: 15675545

GI number: 15675545

Start: 1398444

End: 1399970

Strand: Reverse

Name: glpK

Synonym: SPy_1684

Alternate gene names: 15675545

Gene position: 1399970-1398444 (Counterclockwise)

Preceding gene: 15675546

Following gene: 15675544

Centisome position: 75.57

GC content: 41.98

Gene sequence:

>1527_bases
ATGTCGCAAGAAAAGTATATCATGGCTATTGATCAGGGAACAACAAGTTCACGAGCGATTATTTTCAATCAAAAAGGGGA
AAAGGTTAGCAGTAGCCAAAAAGAATTCCCTCAGATTTTCCCACACGCTGGTTGGGTAGAGCACAATGCTAATCAGATTT
GGAATTCGGTTCAGTCTGTTATTGCGGGTGCTTTTATTGAGTCTAGCATCAAACCAAGCCAAATTGAAGCAATCGGAATT
ACCAACCAACGTGAGACCACAGTGGTTTGGGACAAAAAAACGGGTGTACCTATTTATAATGCTATTGTGTGGCAATCACG
GCAGACGGCACCAATTGCTGAGCAACTCAAACAAGATGGCCATACAAAAATGATCCATGAAAAGACAGGCCTTGTTATTG
ATGCTTACTTTTCTGCAACCAAGATCCGTTGGATTTTGGACCATGTTCCTGGTGCTCAAGAACGAGCTGAAAAAGGCGAG
TTACTTTTTGGAACCATTGATACTTGGCTGGTTTGGAAATTGACAGATGGTGCTGTTCATGTGACGGATTATTCCAATGC
GGCTCGTACCATGCTCTATAATATTAAAGACTTAACATGGGATGATGAGATTTTAGAGCTTTTAAATATTCCAAAAGATA
TGCTTCCAGAGGTTAAATCCAATTCTGAAATTTATGGCAAAACAGCTGCCTTTCATTTTTATGGGGGCGAAGTGCCTATT
TCAGGTATGGCGGGTGACCAACAGGCAGCTTTGTTTGGCCAACTAGCTTTTGAGCCTGGTATGGTGAAAAACACTTATGG
CACAGGTTCTTTCATTATCATGAATACTGGTGATGAGATGCAGTTATCGAGTAATAATCTTTTGACCACCATTGGTTACG
GGATTAATGGGAAGGTTCACTATGCCTTGGAAGGTTCCATCTTTATTGCAGGCTCTGCCATTCAATGGTTGCGAGATGGT
CTTAAAATGATTGAGACTTCACCAGAATCTGAACAGTTCGCTCTAGCATCAACTAGTGACGATGAAGTTTATGTTGTGCC
TGCTTTTACCGGTTTAGGAGCTCCTTACTGGGATTCTAATGCGCGTGGATCTGTCTTTGGCTTGACACGTGGTACCAGCA
AAGAAGACTTTGTCAAAGCAACCTTACAATCTATCGCCTATCAAGTGCGAGATGTTATTGATACCATGCAGGTGGATTCA
GGTATTGACATTCAACAGCTCCGTGTGGATGGCGGTGCAGCCATGAATAATATGCTCATGCAATTTCAGGCTGATATTTT
AGGAATTGATATTGCCCGTGCTAAAAATTTAGAAACAACAGCTCTAGGAGCAGCTTTCTTAGCAGGGCTTGCTGTGGGGT
ATTGGGAAGATATGGATGCTTTGAAAGAATTAAATGCCACAGGCCAGCTCTTTAAGGCTAGCATGAATGAATCGCGCAAA
GAAAAATTATACAAGGGTTGGAAGCGCGCTGTTAAAGCAACTCAAGTTTTCACCCAAGAAGAAGATGCAGATGACGATGC
AAAATAA

Upstream 100 bases:

>100_bases
AGCTTTTTTTTAGCTTTAAAAATTCTTGATAATATATTTCTGATAAAATTAGCTATAATAGAATCAAATAGGAAAACGCT
TACTTAAAGGAGGGTAATGA

Downstream 100 bases:

>100_bases
CTAGAGGAGGATGGAATGGAATTTTCAAGAGAAACAAGACGCTTAGCTCTCCAAAAAATGCAAGAAAGAGATTTAGACCT
ACTGATTATTGGGGGAGGTA

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MSQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAGWVEHNANQIWNSVQSVIAGAFIESSIKPSQIEAIGI
TNQRETTVVWDKKTGVPIYNAIVWQSRQTAPIAEQLKQDGHTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGE
LLFGTIDTWLVWKLTDGAVHVTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEVKSNSEIYGKTAAFHFYGGEVPI
SGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGDEMQLSSNNLLTTIGYGINGKVHYALEGSIFIAGSAIQWLRDG
LKMIETSPESEQFALASTSDDEVYVVPAFTGLGAPYWDSNARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMQVDS
GIDIQQLRVDGGAAMNNMLMQFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDMDALKELNATGQLFKASMNESRK
EKLYKGWKRAVKATQVFTQEEDADDDAK

Sequences:

>Translated_508_residues
MSQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAGWVEHNANQIWNSVQSVIAGAFIESSIKPSQIEAIGI
TNQRETTVVWDKKTGVPIYNAIVWQSRQTAPIAEQLKQDGHTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGE
LLFGTIDTWLVWKLTDGAVHVTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEVKSNSEIYGKTAAFHFYGGEVPI
SGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGDEMQLSSNNLLTTIGYGINGKVHYALEGSIFIAGSAIQWLRDG
LKMIETSPESEQFALASTSDDEVYVVPAFTGLGAPYWDSNARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMQVDS
GIDIQQLRVDGGAAMNNMLMQFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDMDALKELNATGQLFKASMNESRK
EKLYKGWKRAVKATQVFTQEEDADDDAK
>Mature_507_residues
SQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAGWVEHNANQIWNSVQSVIAGAFIESSIKPSQIEAIGIT
NQRETTVVWDKKTGVPIYNAIVWQSRQTAPIAEQLKQDGHTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGEL
LFGTIDTWLVWKLTDGAVHVTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEVKSNSEIYGKTAAFHFYGGEVPIS
GMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGDEMQLSSNNLLTTIGYGINGKVHYALEGSIFIAGSAIQWLRDGL
KMIETSPESEQFALASTSDDEVYVVPAFTGLGAPYWDSNARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMQVDSG
IDIQQLRVDGGAAMNNMLMQFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDMDALKELNATGQLFKASMNESRKE
KLYKGWKRAVKATQVFTQEEDADDDAK

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family

Homologues:

Organism=Homo sapiens, GI189409120, Length=518, Percent_Identity=44.980694980695, Blast_Score=421, Evalue=1e-118,
Organism=Homo sapiens, GI4504007, Length=500, Percent_Identity=45.8, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI42794763, Length=504, Percent_Identity=45.2380952380952, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI41393575, Length=517, Percent_Identity=44.294003868472, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI88196792, Length=503, Percent_Identity=32.4055666003976, Blast_Score=296, Evalue=3e-80,
Organism=Escherichia coli, GI1790361, Length=502, Percent_Identity=56.7729083665339, Blast_Score=616, Evalue=1e-177,
Organism=Escherichia coli, GI1790005, Length=520, Percent_Identity=22.5, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1789987, Length=456, Percent_Identity=24.5614035087719, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787789, Length=487, Percent_Identity=24.2299794661191, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789168, Length=475, Percent_Identity=21.4736842105263, Blast_Score=79, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17535599, Length=448, Percent_Identity=42.1875, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71986140, Length=515, Percent_Identity=26.2135922330097, Blast_Score=178, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI71986147, Length=294, Percent_Identity=31.2925170068027, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6321755, Length=545, Percent_Identity=31.9266055045872, Blast_Score=300, Evalue=5e-82,
Organism=Drosophila melanogaster, GI17864214, Length=502, Percent_Identity=43.4262948207171, Blast_Score=400, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24654573, Length=454, Percent_Identity=43.6123348017621, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24655555, Length=496, Percent_Identity=38.7096774193548, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655560, Length=496, Percent_Identity=38.7096774193548, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655570, Length=496, Percent_Identity=38.7096774193548, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655574, Length=496, Percent_Identity=38.7096774193548, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24655565, Length=496, Percent_Identity=38.7096774193548, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19922058, Length=536, Percent_Identity=33.0223880597015, Blast_Score=297, Evalue=1e-80,
Organism=Drosophila melanogaster, GI24652871, Length=503, Percent_Identity=33.2007952286282, Blast_Score=281, Evalue=9e-76,
Organism=Drosophila melanogaster, GI24656367, Length=492, Percent_Identity=26.219512195122, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI21357867, Length=508, Percent_Identity=25.1968503937008, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24656372, Length=328, Percent_Identity=28.0487804878049, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45552909, Length=280, Percent_Identity=25.3571428571429, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): GLPK_STRP1 (Q99YI7)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269719.1
- RefSeq:   YP_282744.1
- ProteinModelPortal:   Q99YI7
- SMR:   Q99YI7
- EnsemblBacteria:   EBSTRT00000000413
- EnsemblBacteria:   EBSTRT00000027939
- GeneID:   3571496
- GeneID:   901930
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1684
- KEGG:   spz:M5005_Spy_1381
- GeneTree:   EBGT00050000027360
- HOGENOM:   HBG511469
- OMA:   KPSSEVY
- ProtClustDB:   PRK00047
- BioCyc:   SPYO160490:SPY1684-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1381-MONOMER
- HAMAP:   MF_00186
- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999
- PANTHER:   PTHR10196
- PANTHER:   PTHR10196:SF9
- TIGRFAMs:   TIGR01311

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N

EC number: =2.7.1.30

Molecular weight: Translated: 56054; Mature: 55923

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00933 FGGY_KINASES_1; PS00445 FGGY_KINASES_2

Important sites: BINDING 14-14 BINDING 18-18 BINDING 84-84 BINDING 136-136 BINDING 246-246 BINDING 268-268 BINDING 311-311

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAGWVEHNANQIWNSVQSV
CCCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
IAGAFIESSIKPSQIEAIGITNQRETTVVWDKKTGVPIYNAIVWQSRQTAPIAEQLKQDG
HHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEHEEECCCCCCHHHHHHHHCC
HTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGELLFGTIDTWLVWKLTDGAVH
CCEEEECCCCEEEEEECCHHHHHHHHHCCCCHHHHHCCCCEEEEEECEEEEEEEECCEEE
VTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEVKSNSEIYGKTAAFHFYGGEVPI
EEECCCHHHHHEEECCCCCCCHHHHHHHCCCHHHCCCCCCCCCEEEEEEEEEEECCCEEE
SGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGDEMQLSSNNLLTTIGYGINGKVH
CCCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCEEECCCCEEEEEECCCCCEEE
YALEGSIFIAGSAIQWLRDGLKMIETSPESEQFALASTSDDEVYVVPAFTGLGAPYWDSN
EEEECCEEEECHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCC
ARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMQVDSGIDIQQLRVDGGAAMNNMLM
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
QFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDMDALKELNATGQLFKASMNESRK
HHHHHHHEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHH
EKLYKGWKRAVKATQVFTQEEDADDDAK
HHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SQEKYIMAIDQGTTSSRAIIFNQKGEKVSSSQKEFPQIFPHAGWVEHNANQIWNSVQSV
CCCCEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
IAGAFIESSIKPSQIEAIGITNQRETTVVWDKKTGVPIYNAIVWQSRQTAPIAEQLKQDG
HHHHHHHCCCCCCCEEEEECCCCCCEEEEEECCCCCCEEEHEEECCCCCCHHHHHHHHCC
HTKMIHEKTGLVIDAYFSATKIRWILDHVPGAQERAEKGELLFGTIDTWLVWKLTDGAVH
CCEEEECCCCEEEEEECCHHHHHHHHHCCCCHHHHHCCCCEEEEEECEEEEEEEECCEEE
VTDYSNAARTMLYNIKDLTWDDEILELLNIPKDMLPEVKSNSEIYGKTAAFHFYGGEVPI
EEECCCHHHHHEEECCCCCCCHHHHHHHCCCHHHCCCCCCCCCEEEEEEEEEEECCCEEE
SGMAGDQQAALFGQLAFEPGMVKNTYGTGSFIIMNTGDEMQLSSNNLLTTIGYGINGKVH
CCCCCCCHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCEEECCCCEEEEEECCCCCEEE
YALEGSIFIAGSAIQWLRDGLKMIETSPESEQFALASTSDDEVYVVPAFTGLGAPYWDSN
EEEECCEEEECHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCC
ARGSVFGLTRGTSKEDFVKATLQSIAYQVRDVIDTMQVDSGIDIQQLRVDGGAAMNNMLM
CCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHH
QFQADILGIDIARAKNLETTALGAAFLAGLAVGYWEDMDALKELNATGQLFKASMNESRK
HHHHHHHEEEHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHH
EKLYKGWKRAVKATQVFTQEEDADDDAK
HHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296