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The map label for this gene is gmk

Identifier: 15675507

GI number: 15675507

Start: 1353463

End: 1354098

Strand: Reverse

Name: gmk

Synonym: SPy_1632

Alternate gene names: 15675507

Gene position: 1354098-1353463 (Counterclockwise)

Preceding gene: 15675508

Following gene: 15675506

Centisome position: 73.1

GC content: 38.99

Gene sequence:

>636_bases
ATGTCTGAACGCGGTTTGTTAATCGTCTTTTCTGGCCCTTCAGGTGTCGGAAAAGGAACGGTAAGACAAGAAATTTTTTC
AACGCCAGATCATAAATTTGAATATTCGGTTTCAATGACGACTCGTCCGCAAAGACCGGGCGAGGTTGATGGGGTTGATT
ATTTCTTCCGCACACGTGAAGAATTTGAAGAACTCATTAAAACTGGTCAAATGCTAGAGTATGCTGAATATGTTGGTAAT
TACTATGGCACCCCTTTAACTTATGTTAATGAGACTCTTGATAAGGGAATTGATGTCTTTTTAGAAATTGAAGTTCAAGG
AGCTCTTCAGGTTAAGTCAAAAGTACCAGATGGTGTTTTTGTTTTTTTAACACCACCAGATTTAGATGAATTAGAAGACC
GCCTGGTTGGTCGTGGTACAGATAGTCAAGAAGTCATAGCTCAACGTATTGAAAGAGCAAAAGAAGAAATTGCCCTTATG
CGCGAATACGATTATGCAGTTGTTAATGATGAAGTTGCCTTGGCAGCTGAGCGGGTTAAGCGTATCATTGAGACAGAACA
CTTTCGTGTGGAGCGCGTGATTGGTCGTTATGATAAAATGATTAAAATAACAAAAAATTCCTTTAAAGCTAAATAG

Upstream 100 bases:

>100_bases
AATTATCCTCTTTTTCTTTATGACTTGCCTTTGAAAATGTTCTTGAAAAAGACTAGCCTTTTTGATAAACTATTAAAAAG
CAACTAATAAGGAGAATACA

Downstream 100 bases:

>100_bases
AAAAGAGTAAGCATTATGATGTTAAAACCTTCCATTGATACCTTATTAGATAAAGTACCATCCAAGTATTCACTTGTGAT
TTTACAAGCCAAACGTGCCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGN
YYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALM
REYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNSFKAK

Sequences:

>Translated_211_residues
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGN
YYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALM
REYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNSFKAK
>Mature_210_residues
SERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTREEFEELIKTGQMLEYAEYVGNY
YGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVFVFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMR
EYDYAVVNDEVALAAERVKRIIETEHFRVERVIGRYDKMIKITKNSFKAK

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=32.9787234042553, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=32.9787234042553, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=32.9787234042553, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI38570142, Length=184, Percent_Identity=28.2608695652174, Blast_Score=85, Evalue=6e-17,
Organism=Homo sapiens, GI14780902, Length=198, Percent_Identity=27.7777777777778, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI4505237, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118259, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118255, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262118263, Length=167, Percent_Identity=29.940119760479, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI21361598, Length=185, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1790080, Length=199, Percent_Identity=44.7236180904523, Blast_Score=171, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=36.046511627907, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=36.046511627907, Blast_Score=117, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17556244, Length=121, Percent_Identity=34.7107438016529, Blast_Score=84, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988041, Length=182, Percent_Identity=24.7252747252747, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71988048, Length=182, Percent_Identity=24.7252747252747, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=38.7978142076503, Blast_Score=135, Evalue=4e-33,
Organism=Drosophila melanogaster, GI21356141, Length=150, Percent_Identity=38, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI161077626, Length=176, Percent_Identity=29.5454545454545, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640542, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45554489, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45554481, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI85724806, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI116007136, Length=176, Percent_Identity=29.5454545454545, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221330164, Length=125, Percent_Identity=32.8, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221330166, Length=125, Percent_Identity=32.8, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330162, Length=125, Percent_Identity=32.8, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI85816106, Length=127, Percent_Identity=31.496062992126, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI85816281, Length=127, Percent_Identity=31.496062992126, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45551002, Length=127, Percent_Identity=31.496062992126, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI281362230, Length=185, Percent_Identity=23.7837837837838, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648808, Length=185, Percent_Identity=23.7837837837838, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_STRP1 (Q99YM5)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269681.1
- RefSeq:   YP_282704.1
- ProteinModelPortal:   Q99YM5
- EnsemblBacteria:   EBSTRT00000001070
- EnsemblBacteria:   EBSTRT00000028040
- GeneID:   3571572
- GeneID:   901884
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1632
- KEGG:   spz:M5005_Spy_1341
- GeneTree:   EBGT00050000028392
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   SPYO160490:SPY1632-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1341-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 24177; Mature: 24046

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTRE
CCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
EFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVF
HHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCEE
VFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMREYDYAVVNDEVALAAERVK
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHH
RIIETEHFRVERVIGRYDKMIKITKNSFKAK
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCC
>Mature Secondary Structure 
SERGLLIVFSGPSGVGKGTVRQEIFSTPDHKFEYSVSMTTRPQRPGEVDGVDYFFRTRE
CCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHH
EFEELIKTGQMLEYAEYVGNYYGTPLTYVNETLDKGIDVFLEIEVQGALQVKSKVPDGVF
HHHHHHHHCHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEEECCEEEECCCCCCCEE
VFLTPPDLDELEDRLVGRGTDSQEVIAQRIERAKEEIALMREYDYAVVNDEVALAAERVK
EEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHHH
RIIETEHFRVERVIGRYDKMIKITKNSFKAK
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296