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The map label for this gene is msrA [H]

Identifier: 15675450

GI number: 15675450

Start: 1280852

End: 1281958

Strand: Reverse

Name: msrA [H]

Synonym: SPy_1557

Alternate gene names: 15675450

Gene position: 1281958-1280852 (Counterclockwise)

Preceding gene: 15675451

Following gene: 15675449

Centisome position: 69.2

GC content: 41.46

Gene sequence:

>1107_bases
ATGGAACATAAATGGAAATTATGGCTATTTATCGTTGGAGTGGTCTTGTTAATAGGCGGAGCTTCTGTTCTCATTCAGAA
AGGTCAAGCCAAGGCTTTTAGTCAAGGCAAGCCTCAACTACCAGCTAAAAAAGTCAAATCCACTAAAGTAGATCCCAATG
CCCCTGTTGATCAAAAAGTGATTTACCTGGCTGGAGGCTGTTTCTGGGGCGTTGAAGAATATTTTTCACAAGTGGATGGC
GTTCTAGATGCGGTGTCAGGCTATGCCAATGGTAGAGGCGATACCACCAACTACCAGTTAATTCATCAGACTGGTCATGC
AGAAACCGTTGAAGTGGCCTATGATGCGAACCGTATTAGCTTGAAAGAATTATTACTGCATTTTTTCCGAATTATTGACC
CAACCAGTCTTAATAAGCAAGGAAATGATCGCGGTAGTCAATACCGAACTGGGATTTACTATACTGACAAAGCAGATTTA
GCTATTATTGATGAGGTCTTCAAAGAAAAAGCTAAGGATTACAAGAAAAAAATAGTGGTTGAAAAAGCACCATTGAAACA
CTTTATTAAGGCAGAAGACTACCACCAAGATTACCTCAAGAAAAATCCAAATGGCTACTGCCATATTGACATCAACCAAG
CGACTTATCCTGTGATTGATGAAAGCAAGTACCCAAAACCAAGTGCCACTGAGATCAAGGAAAAACTATCTGCAGACGAA
TACCGAGTGACGCAAAAAAACGAAACTGAAAAAGCTTTTTCTAATCGCTACTGGGATTCTTTTGATGCAGGAATTTACGT
AGACGTTGTGACAGGAGAACCGCTTTTCTCTTCAAAAGACAAATTTGAATCAGGTTGTGGTTGGCCAAGCTTTAGCCGCC
CCATCAGCCCAGACGTTGTCCGCTACAAGGAAGATAAGAGTTTCAATATGACGAGAACAGAAGTGCGCAGCCGTTCAGGG
AATTCTCATCTGGGGCATGTCTTTACTGACGGACCTAAAGACCAAGGCGGCCTTCGTTACTGCATCAATAGCTTGTCTAT
TACCTTTATTCCAAAAGCTGATATGGAAGCTAAGGGCTATGGGTATTTATTATCATCTGTAGAATAG

Upstream 100 bases:

>100_bases
ACACATTGGTTATGCCAAAAAATCAGACATCAAAAAGACCCTTAAAGGTATACATTAGGAAGGACCAGCTGATAGGCATT
AGAAAAAAGGAGTTGAGTTT

Downstream 100 bases:

>100_bases
GGTTAAGCCTAAAAATCTGATATAATAGAAGAAAGACTAGTATGAGAGGGCCATGCAAGGCCCTTTATAAAGATAAGGAG
ACACCGTGTGTACTCATTGT

Product: bifunctional methionine sulfoxide reductase A/B protein

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKKVKSTKVDPNAPVDQKVIYLAGGCFWGVEEYFSQVDG
VLDAVSGYANGRGDTTNYQLIHQTGHAETVEVAYDANRISLKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADL
AIIDEVFKEKAKDYKKKIVVEKAPLKHFIKAEDYHQDYLKKNPNGYCHIDINQATYPVIDESKYPKPSATEIKEKLSADE
YRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVVRYKEDKSFNMTRTEVRSRSG
NSHLGHVFTDGPKDQGGLRYCINSLSITFIPKADMEAKGYGYLLSSVE

Sequences:

>Translated_368_residues
MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKKVKSTKVDPNAPVDQKVIYLAGGCFWGVEEYFSQVDG
VLDAVSGYANGRGDTTNYQLIHQTGHAETVEVAYDANRISLKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADL
AIIDEVFKEKAKDYKKKIVVEKAPLKHFIKAEDYHQDYLKKNPNGYCHIDINQATYPVIDESKYPKPSATEIKEKLSADE
YRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVVRYKEDKSFNMTRTEVRSRSG
NSHLGHVFTDGPKDQGGLRYCINSLSITFIPKADMEAKGYGYLLSSVE
>Mature_368_residues
MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKKVKSTKVDPNAPVDQKVIYLAGGCFWGVEEYFSQVDG
VLDAVSGYANGRGDTTNYQLIHQTGHAETVEVAYDANRISLKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADL
AIIDEVFKEKAKDYKKKIVVEKAPLKHFIKAEDYHQDYLKKNPNGYCHIDINQATYPVIDESKYPKPSATEIKEKLSADE
YRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVVRYKEDKSFNMTRTEVRSRSG
NSHLGHVFTDGPKDQGGLRYCINSLSITFIPKADMEAKGYGYLLSSVE

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=124, Percent_Identity=44.3548387096774, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI301336162, Length=124, Percent_Identity=44.3548387096774, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI73089054, Length=124, Percent_Identity=44.3548387096774, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI37620216, Length=124, Percent_Identity=44.3548387096774, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI208609995, Length=188, Percent_Identity=34.5744680851064, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI6912516, Length=174, Percent_Identity=36.2068965517241, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI117606353, Length=130, Percent_Identity=40, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI208609993, Length=133, Percent_Identity=37.593984962406, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=45.9677419354839, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790665, Length=158, Percent_Identity=40.5063291139241, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI115532676, Length=125, Percent_Identity=45.6, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17553450, Length=125, Percent_Identity=45.6, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=40.1234567901235, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319816, Length=124, Percent_Identity=32.258064516129, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45553335, Length=121, Percent_Identity=42.9752066115703, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21356369, Length=121, Percent_Identity=42.9752066115703, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645799, Length=121, Percent_Identity=42.9752066115703, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221378664, Length=124, Percent_Identity=41.1290322580645, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI221378662, Length=131, Percent_Identity=38.9312977099237, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645804, Length=132, Percent_Identity=39.3939393939394, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24645801, Length=132, Percent_Identity=39.3939393939394, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 41506; Mature: 41506

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKKVKSTKVDPNAPVDQKV
CCCCHHHHHHHHHHHHHHCCCHHEEECCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCEE
IYLAGGCFWGVEEYFSQVDGVLDAVSGYANGRGDTTNYQLIHQTGHAETVEVAYDANRIS
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCC
LKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADLAIIDEVFKEKAKDYKKKIVV
HHHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCCHHHHHHHHHHHHHHHHHHHEE
EKAPLKHFIKAEDYHQDYLKKNPNGYCHIDINQATYPVIDESKYPKPSATEIKEKLSADE
ECCCHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCC
YRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVV
EEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCE
RYKEDKSFNMTRTEVRSRSGNSHLGHVFTDGPKDQGGLRYCINSLSITFIPKADMEAKGY
EECCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCC
GYLLSSVE
CCEECCCC
>Mature Secondary Structure
MEHKWKLWLFIVGVVLLIGGASVLIQKGQAKAFSQGKPQLPAKKVKSTKVDPNAPVDQKV
CCCCHHHHHHHHHHHHHHCCCHHEEECCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCEE
IYLAGGCFWGVEEYFSQVDGVLDAVSGYANGRGDTTNYQLIHQTGHAETVEVAYDANRIS
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCC
LKELLLHFFRIIDPTSLNKQGNDRGSQYRTGIYYTDKADLAIIDEVFKEKAKDYKKKIVV
HHHHHHHHHHHCCCCCCCCCCCCCCCCEECCEEEECCCCHHHHHHHHHHHHHHHHHHHEE
EKAPLKHFIKAEDYHQDYLKKNPNGYCHIDINQATYPVIDESKYPKPSATEIKEKLSADE
ECCCHHHHHHCCHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCC
YRVTQKNETEKAFSNRYWDSFDAGIYVDVVTGEPLFSSKDKFESGCGWPSFSRPISPDVV
EEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHCCCCCCCCCCCCCCCCE
RYKEDKSFNMTRTEVRSRSGNSHLGHVFTDGPKDQGGLRYCINSLSITFIPKADMEAKGY
EECCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHHCCEEEEEECCCCCCCCC
GYLLSSVE
CCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]