Click here to switch to the map view.

The map label for this gene is coaD

Identifier: 15675436

GI number: 15675436

Start: 1265431

End: 1265922

Strand: Reverse

Name: coaD

Synonym: SPy_1537

Alternate gene names: 15675436

Gene position: 1265922-1265431 (Counterclockwise)

Preceding gene: 15675437

Following gene: 15675435

Centisome position: 68.34

GC content: 34.96

Gene sequence:

>492_bases
ATGTTAACTAAAATAGGACTTTATACAGGGTCATTTGATCCTGTTACAAACGGTCATCTCGATATTGTTAAACGGGCAAG
TGGCCTATTTGATCAAATATATGTTGGGATTTTTGATAATCCTACCAAAAAAAGCTATTTTAAACTAGAAGTTCGTAAAG
CAATGCTTACTCAAGCTCTGGCTGATTTTACAAATGTAATTGTAGTAACTTCGCACGAACGTTTAGCTATTGATGTAGCT
AAAGAATTACGAGTAACTCACTTGATTAGAGGCTTGCGAAATGCAACTGACTTTGAGTATGAAGAAAATTTGGAATATTT
TAATCACCTTTTAGCTCCAAATATTGAAACCGTCTATTTGATATCAAGAAATAAATGGCAGGCCCTTAGCTCTAGTCGTG
TGAGAGAGCTAATTCATTTTCAGTCTTCCTTAGAAGGTTTGGTTCCTCAGTCGGTTATTGCTCAAGTGGAGAAAATGAAT
GAAAAGACTTAA

Upstream 100 bases:

>100_bases
GTTGTCTGTGAGACAGATAAAACAGTCTTGTTGCCAAAAGAGATTGCAACGTTAGGTATTTGGAAAGAAAAAATTTATGG
AATTAGTAAGGTAACAGTTT

Downstream 100 bases:

>100_bases
AAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCCGCTACCTTATTATA
TTGAAATGCCTGGAGGCGCT

Product: phosphopantetheine adenylyltransferase

Products: NA

Alternate protein names: Dephospho-CoA pyrophosphorylase; Pantetheine-phosphate adenylyltransferase; PPAT

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFTNVIVVTSHERLAIDVA
KELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMN
EKT

Sequences:

>Translated_163_residues
MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFTNVIVVTSHERLAIDVA
KELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMN
EKT
>Mature_163_residues
MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFTNVIVVTSHERLAIDVA
KELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMN
EKT

Specific function: Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

COG id: COG0669

COG function: function code H; Phosphopantetheine adenylyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial CoaD family

Homologues:

Organism=Escherichia coli, GI1790065, Length=151, Percent_Identity=41.7218543046358, Blast_Score=125, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COAD_STRP1 (P63821)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269610.1
- RefSeq:   YP_282630.1
- ProteinModelPortal:   P63821
- SMR:   P63821
- EnsemblBacteria:   EBSTRT00000000128
- EnsemblBacteria:   EBSTRT00000028494
- GeneID:   3571657
- GeneID:   901581
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_1537
- KEGG:   spz:M5005_Spy_1267
- GeneTree:   EBGT00050000028176
- HOGENOM:   HBG288308
- OMA:   VRQIAAM
- ProtClustDB:   PRK00168
- BioCyc:   SPYO160490:SPY1537-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1267-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00151
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR001980
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR01020
- TIGRFAMs:   TIGR01510
- TIGRFAMs:   TIGR00125

Pfam domain/function: PF01467 CTP_transf_2

EC number: =2.7.7.3

Molecular weight: Translated: 18630; Mature: 18630

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQAL
CCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHH
ADFTNVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYL
HHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
ISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMNEKT
EECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTKIGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQAL
CCEEEEEEECCCCCCCCCHHHHHHHHHCHHHHHEEEECCCCCCCHHHHHHHHHHHHHHHH
ADFTNVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYL
HHHHCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCEEEE
ISRNKWQALSSSRVRELIHFQSSLEGLVPQSVIAQVEKMNEKT
EECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296