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The map label for this gene is ygcA [C]

Identifier: 15675282

GI number: 15675282

Start: 1113997

End: 1115385

Strand: Reverse

Name: ygcA [C]

Synonym: SPy_1346

Alternate gene names: 15675282

Gene position: 1115385-1113997 (Counterclockwise)

Preceding gene: 15675283

Following gene: 15675281

Centisome position: 60.21

GC content: 40.82

Gene sequence:

>1389_bases
ATGGTTAGCCCTAGAAAAGGAAAAAGAATAAGAATGTTGAAAAAAAATGATATTATCCAAGTTGCTATTTCAGATTTAAG
CCATGAGGGAGCAGGTGTCGCTAAACACGATGGTTTTGTTTTCTTTGTTGATAATGCCTTGCCAGAAGAAGTGATTGACA
TGCGTGTCTTAAAGGTCAATAAAAACAGCGGTTTTGGCAAAGTAGAAGCCTATCATTACCTGTCGTCAGCTAGAAATGCA
GATGTCAATTTAACTTATTTGCGAACAGGCATTGCAGACCTTGGACATCTAACTTATGAAGACCAACTGACTTTCAAAAA
GAAACAAGTTCAGGACAGCCTCTATAAAATTGCTGGAATCAGTGACGTGACAGTCGAAAGCACGATTGGGATGACAGAAC
CTTTAGCTTACCGAAATAAGGCTCAAGTTCCTGTTAGACGTGTTAATGGTCAGCTAGAAACAGGCTTTTTCCGCAAGCAT
TCTCATGACTTGATTCCTATTTCGGATTATTATATTCAGGACAAAGAGATTGATCGTCTCATTAATTTTACCCGTGATTT
ATTACGCCGCTTTGATATTAAACCGTATGACGAAACAGAACAAACAGGTCTCTTGAGAAATATTGTTGTTCGCCGAGGTC
ATTACTCTGGAGAAATGATGCTGGTCTTAGTGACTACACGCCCAAAAGTTTTCCGTGTTGACCAAGTCATTGAAAAAATC
GTTGAAGCTTTTCCAGCAGTGGTGTCTATTATTCAAAATATTAATGATAAGAACACCAATGCAATCTTTGGTAAAGATTT
CAAAACGCTTTACGGCAAGGATACCATTACTGATAGCATGCTTGGAAACAACTATGCCATTTCTGCTCAGTCTTTCTACC
AAGTGAATACGGTTATGGCAGAAAAACTCTATCAAACAGCTATAGCCTTTTCAGACCTTTCTAAAGATGATATTGTGATT
GACGCCTACTCAGGTATCGGAACCATTGGCCTATCATTTGCTAAAACCGTTAAAGCTGTTTATGGTGTTGAAGTGATTGA
AGCAGCTGTTAGAGATGCTCAACAGAATGCCGCTCTTAATGGCATCACCAATGCCTACTTTGTCGCAGATACCGCAGAAC
ATGCCATGGCAACATGGGCGAAAGATGGCATCAAACCAAGTGTTATTCTGGTAGACCCGCCACGAAAAGGCTTAACAGAA
AGTTTCATCCAAGCCAGCGTGGCAATGGGACCACAAAAAATTACCTACGTTTCCTGCAACCCAGCCACCATGGCGCGTGA
CATAAAGCGTTATCAAGAGTTGGGTTACAAACTGGCCAAAGTACAGCCCGTAGATTTGTTTCCGCAAACGCATCACGTCG
AGTGCGTAGTATTGCTAATCAAGGAGTAA

Upstream 100 bases:

>100_bases
CATAGATTTTGATAAGTATCAGAAAACGTTAGCCAAATTAGGTCTGCGCTAAGATATGGTATAATGGAGAGTAACTAAAG
TTGCTCTTCTTTTTTGAGCA

Downstream 100 bases:

>100_bases
GGTAGCTGCCTCCACATGACAAAAATAAGGAGAAACGAATGCCTATTACCAAACACGAGATTCCCCTTTTAGAATGTGAT
AGTAATCCATCAGCCGTCAT

Product: putative RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHDGFVFFVDNALPEEVIDMRVLKVNKNSGFGKVEAYHYLSSARNA
DVNLTYLRTGIADLGHLTYEDQLTFKKKQVQDSLYKIAGISDVTVESTIGMTEPLAYRNKAQVPVRRVNGQLETGFFRKH
SHDLIPISDYYIQDKEIDRLINFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGEMMLVLVTTRPKVFRVDQVIEKI
VEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTITDSMLGNNYAISAQSFYQVNTVMAEKLYQTAIAFSDLSKDDIVI
DAYSGIGTIGLSFAKTVKAVYGVEVIEAAVRDAQQNAALNGITNAYFVADTAEHAMATWAKDGIKPSVILVDPPRKGLTE
SFIQASVAMGPQKITYVSCNPATMARDIKRYQELGYKLAKVQPVDLFPQTHHVECVVLLIKE

Sequences:

>Translated_462_residues
MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHDGFVFFVDNALPEEVIDMRVLKVNKNSGFGKVEAYHYLSSARNA
DVNLTYLRTGIADLGHLTYEDQLTFKKKQVQDSLYKIAGISDVTVESTIGMTEPLAYRNKAQVPVRRVNGQLETGFFRKH
SHDLIPISDYYIQDKEIDRLINFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGEMMLVLVTTRPKVFRVDQVIEKI
VEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTITDSMLGNNYAISAQSFYQVNTVMAEKLYQTAIAFSDLSKDDIVI
DAYSGIGTIGLSFAKTVKAVYGVEVIEAAVRDAQQNAALNGITNAYFVADTAEHAMATWAKDGIKPSVILVDPPRKGLTE
SFIQASVAMGPQKITYVSCNPATMARDIKRYQELGYKLAKVQPVDLFPQTHHVECVVLLIKE
>Mature_462_residues
MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHDGFVFFVDNALPEEVIDMRVLKVNKNSGFGKVEAYHYLSSARNA
DVNLTYLRTGIADLGHLTYEDQLTFKKKQVQDSLYKIAGISDVTVESTIGMTEPLAYRNKAQVPVRRVNGQLETGFFRKH
SHDLIPISDYYIQDKEIDRLINFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGEMMLVLVTTRPKVFRVDQVIEKI
VEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTITDSMLGNNYAISAQSFYQVNTVMAEKLYQTAIAFSDLSKDDIVI
DAYSGIGTIGLSFAKTVKAVYGVEVIEAAVRDAQQNAALNGITNAYFVADTAEHAMATWAKDGIKPSVILVDPPRKGLTE
SFIQASVAMGPQKITYVSCNPATMARDIKRYQELGYKLAKVQPVDLFPQTHHVECVVLLIKE

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI269784680, Length=428, Percent_Identity=27.1028037383178, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI269784676, Length=428, Percent_Identity=27.1028037383178, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI20149688, Length=428, Percent_Identity=27.1028037383178, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI34222389, Length=296, Percent_Identity=29.7297297297297, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI51173878, Length=296, Percent_Identity=29.7297297297297, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI269784678, Length=365, Percent_Identity=27.6712328767123, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1789148, Length=464, Percent_Identity=26.7241379310345, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787083, Length=331, Percent_Identity=27.7945619335347, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790403, Length=186, Percent_Identity=32.258064516129, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71997438, Length=488, Percent_Identity=24.3852459016393, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322909, Length=443, Percent_Identity=24.1534988713318, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24666579, Length=361, Percent_Identity=29.3628808864266, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51733; Mature: 51733

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS50926 TRAM ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHDGFVFFVDNALPEEVIDMRVLKVN
CCCCCCCCEEEEECCCCEEEEEEHHCCCCCCCEEECCCEEEEECCCCCHHHHCEEEEEEE
KNSGFGKVEAYHYLSSARNADVNLTYLRTGIADLGHLTYEDQLTFKKKQVQDSLYKIAGI
CCCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCEECHHHHHHHHHHHHHHHHHCCC
SDVTVESTIGMTEPLAYRNKAQVPVRRVNGQLETGFFRKHSHDLIPISDYYIQDKEIDRL
CCEEEHHHCCCCCCHHCCCCCCCCHHHHCCCCCCCHHHHCCCCEEECHHCEECHHHHHHH
INFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGEMMLVLVTTRPKVFRVDQVIEKI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEHHHHHHHH
VEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTITDSMLGNNYAISAQSFYQVNTVMA
HHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCCCHHHHHHCCCCEEEEHHHHHHHHHHHH
EKLYQTAIAFSDLSKDDIVIDAYSGIGTIGLSFAKTVKAVYGVEVIEAAVRDAQQNAALN
HHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GITNAYFVADTAEHAMATWAKDGIKPSVILVDPPRKGLTESFIQASVAMGPQKITYVSCN
CCCCEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECC
PATMARDIKRYQELGYKLAKVQPVDLFPQTHHVECVVLLIKE
HHHHHHHHHHHHHHCCEEHEECCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure
MVSPRKGKRIRMLKKNDIIQVAISDLSHEGAGVAKHDGFVFFVDNALPEEVIDMRVLKVN
CCCCCCCCEEEEECCCCEEEEEEHHCCCCCCCEEECCCEEEEECCCCCHHHHCEEEEEEE
KNSGFGKVEAYHYLSSARNADVNLTYLRTGIADLGHLTYEDQLTFKKKQVQDSLYKIAGI
CCCCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHCCCEECHHHHHHHHHHHHHHHHHCCC
SDVTVESTIGMTEPLAYRNKAQVPVRRVNGQLETGFFRKHSHDLIPISDYYIQDKEIDRL
CCEEEHHHCCCCCCHHCCCCCCCCHHHHCCCCCCCHHHHCCCCEEECHHCEECHHHHHHH
INFTRDLLRRFDIKPYDETEQTGLLRNIVVRRGHYSGEMMLVLVTTRPKVFRVDQVIEKI
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEHHHHHHHH
VEAFPAVVSIIQNINDKNTNAIFGKDFKTLYGKDTITDSMLGNNYAISAQSFYQVNTVMA
HHHHHHHHHHHHHCCCCCCCEEECCCHHHHCCCCHHHHHHCCCCEEEEHHHHHHHHHHHH
EKLYQTAIAFSDLSKDDIVIDAYSGIGTIGLSFAKTVKAVYGVEVIEAAVRDAQQNAALN
HHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GITNAYFVADTAEHAMATWAKDGIKPSVILVDPPRKGLTESFIQASVAMGPQKITYVSCN
CCCCEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECC
PATMARDIKRYQELGYKLAKVQPVDLFPQTHHVECVVLLIKE
HHHHHHHHHHHHHHCCEEHEECCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12122206; 12799345 [H]