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The map label for this gene is ciaR [H]

Identifier: 15675198

GI number: 15675198

Start: 1019327

End: 1020001

Strand: Reverse

Name: ciaR [H]

Synonym: SPy_1237

Alternate gene names: 15675198

Gene position: 1020001-1019327 (Counterclockwise)

Preceding gene: 15675199

Following gene: 15675197

Centisome position: 55.06

GC content: 31.56

Gene sequence:

>675_bases
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGCCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCTGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGATATATTCTAAAAAACAATGAATAA

Upstream 100 bases:

>100_bases
AGCTTTTTGTAGTATAGTCTCGTTAGAAATTGTTATCAGAAATGAGACTAAGTTAAATGAAGTGATAGTTACTTTATTTA
AGAACAATTGAGGTAGAGAC

Downstream 100 bases:

>100_bases
ATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTTTGTCATTA
TGACTATTATTATCTTACAG

Product: putative response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE

Sequences:

>Translated_224_residues
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE
>Mature_224_residues
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE

Specific function: Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=36.7713004484305, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=34.2342342342342, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=35.2678571428571, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=33.9449541284404, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=29.4117647058824, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1786911, Length=207, Percent_Identity=32.3671497584541, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=31.6742081447964, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=29.1479820627803, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI2367329, Length=234, Percent_Identity=33.7606837606838, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788394, Length=205, Percent_Identity=30.2439024390244, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=29.8245614035088, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.5154185022026, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=27.7533039647577, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=28.9915966386555, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=119, Percent_Identity=31.9327731092437, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788550, Length=72, Percent_Identity=37.5, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25651; Mature: 25651

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGF
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCCCCH
QVLKELREKDIKIPVLIMTAKEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTG
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHC
KFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVYLLQNQNVILPKTQIFDRLWG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCEECCHHHHHHHHHC
FDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGF
CEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHCCCCCCH
QVLKELREKDIKIPVLIMTAKEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTG
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHC
KFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVYLLQNQNVILPKTQIFDRLWG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEECCCCEECCHHHHHHHHHC
FDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE
CCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]