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The map label for this gene is dfp [H]

Identifier: 15675186

GI number: 15675186

Start: 1006663

End: 1007208

Strand: Direct

Name: dfp [H]

Synonym: SPy_1222

Alternate gene names: 15675186

Gene position: 1006663-1007208 (Clockwise)

Preceding gene: 15675185

Following gene: 15675187

Centisome position: 54.34

GC content: 35.9

Gene sequence:

>546_bases
ATGACTAAACATATTACCTTAGCTGTTTCTGGTAGTATATCTGCCTATAAAGCAGCAGATCTTACGAGTCAATTAACTAA
AATTGGCTATGATGTTCACATCATAATGACTCAGGCTGCTACACAATTTATTACACCATTAACCCTGCAAGTGTTATCAA
AAAATGCTATTCATTTAGATGTTATGGATGAGCATGACCCAAAAGTTATCAACCATATCGAATTAGCAAAACGCACAGAT
TTATTTATTGTTGCACCTGCCTCTGCTAATACTATTGCTCATCTAGCATATGGATTCGCTGATAATCTTGTAACAAGTGT
TGCTCTTGCCCTACCAGCTACCACACCAAAATTAATAGCCCCAGCCATGAATACCAAAATGTATCAAAACCCTATTACTC
AAGAAAATATTAAACGCTTATCGACAATAGGGTTTACAGAAATTCCTCCAAAATCTAGCTTATTAGCCTGTGGAGATAAA
GGACCTGGTGCTTTGGCTGATATTGATGTTATCTTAGCTACTATTGATACGATTTGGAAACTTTAA

Upstream 100 bases:

>100_bases
ACAGGTATGCACAAGGCTCTTTTGATATCCAATAACGAAGTTGCATCTGCAGATACCAAAGAGGCAATTGCTGACTTATT
ATATGAAAGGATGACCAAAC

Downstream 100 bases:

>100_bases
CAGTCGTTTTTCTGATCACCTTTTTAGAATTAAGTATTATATTTTTTGGAGAGTAAAATGAATCACCGTAAATCAGCAGA
TATTTCTCGTATTGCTATCT

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: PPCDC [H]

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MTKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLDVMDEHDPKVINHIELAKRTD
LFIVAPASANTIAHLAYGFADNLVTSVALALPATTPKLIAPAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDK
GPGALADIDVILATIDTIWKL

Sequences:

>Translated_181_residues
MTKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLDVMDEHDPKVINHIELAKRTD
LFIVAPASANTIAHLAYGFADNLVTSVALALPATTPKLIAPAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDK
GPGALADIDVILATIDTIWKL
>Mature_180_residues
TKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLDVMDEHDPKVINHIELAKRTDL
FIVAPASANTIAHLAYGFADNLVTSVALALPATTPKLIAPAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDKG
PGALADIDVILATIDTIWKL

Specific function: Catalyzes the decarboxylation of 4'- phosphopantothenoylcysteine to 4'-phosphopantetheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=177, Percent_Identity=36.1581920903955, Blast_Score=120, Evalue=7e-28,
Organism=Escherichia coli, GI87082301, Length=165, Percent_Identity=44.2424242424242, Blast_Score=135, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17560194, Length=182, Percent_Identity=38.4615384615385, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6322762, Length=196, Percent_Identity=33.1632653061224, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24657262, Length=184, Percent_Identity=35.8695652173913, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011847
- InterPro:   IPR003382 [H]

Pfam domain/function: PF02441 Flavoprotein [H]

EC number: =4.1.1.36 [H]

Molecular weight: Translated: 19444; Mature: 19313

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLD
CCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEE
VMDEHDPKVINHIELAKRTDLFIVAPASANTIAHLAYGFADNLVTSVALALPATTPKLIA
EECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDKGPGALADIDVILATIDTIWK
HHHCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure 
TKHITLAVSGSISAYKAADLTSQLTKIGYDVHIIMTQAATQFITPLTLQVLSKNAIHLD
CCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHHHCCCCEEEE
VMDEHDPKVINHIELAKRTDLFIVAPASANTIAHLAYGFADNLVTSVALALPATTPKLIA
EECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
PAMNTKMYQNPITQENIKRLSTIGFTEIPPKSSLLACGDKGPGALADIDVILATIDTIWK
HHHCCHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]