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The map label for this gene is guaA [H]

Identifier: 15675169

GI number: 15675169

Start: 987471

End: 989033

Strand: Direct

Name: guaA [H]

Synonym: SPy_1204

Alternate gene names: 15675169

Gene position: 987471-989033 (Clockwise)

Preceding gene: 15675164

Following gene: 15675174

Centisome position: 53.31

GC content: 40.75

Gene sequence:

>1563_bases
ATGACTGAAATTTCAATTTTGAATGATGTTCAAAAAATTATCGTTCTTGATTATGGTAGCCAGTACAATCAGCTTATTGC
TAGACGTATTCGAGAGTTTGGTGTTTTCTCCGAACTAAAAAGCCATAAAATCACCGCTCAAGAACTTCGTGAGATCAATC
CCATAGGTATCGTTTTATCAGGAGGGCCTAACTCTGTTTACGCTGATAACGCCTTTGGCATTGACCCTGAAATCTTTGAA
CTAGGGATTCCGATTCTTGGTATCTGTTACGGTATGCAATTAATCACCCATAAATTAGGTGGTAAAGTTGTTCCTGCTGG
ACAAGCTGGTAATCGTGAATACGGTCAGTCAACCCTTCATCTTCGTGAAACGTCAAAATTATTTTCAGGCACACCTCAAG
AACAACTCGTTTTGATGAGCCATGGTGATGCTGTTACTGAAATTCCAGAAGGTTTCCACCTTGTTGGAGACTCAAATGAC
TGTCCCTATGCAGCTATTGAAAATACTGAGAAAAACCTTTACGGTATTCAGTTCCACCCAGAAGTGAGACACTCTGTTTA
TGGAAATGACATTCTTAAAAACTTTGCTATATCAATTTGTGGCGCGCGTGGTGATTGGTCAATGGATAATTTTATTGACA
TGGAAATTGCTAAAATTCGTGAAACTGTAGGCGATCGTAAAGTTCTTCTAGGTCTTTCTGGTGGAGTTGATTCTTCAGTT
GTTGGTGTTCTACTTCAAAAAGCTATCGGTGACCAATTAACTTGTATTTTCGTTGATCACGGTCTTCTTCGTAAAGACGA
GGGCGATCAAGTTATGGGAATGCTTGGGGGCAAATTTGGCCTAAATATTATCCGTGTGGATGCTTCAAAACGTTTCTTAG
ACCTTCTTGCAGACGTTGAAGATCCTGAGAAAAAACGTAAAATTATTGGTAATGAATTTGTCTATGTTTTTGATGATGAA
GCCAGCAAATTAAAAGGTGTTGACTTCCTTGCCCAAGGAACACTTTATACTGATATCATTGAGTCAGGAACAGAAACTGC
TCAAACCATCAAATCACATCACAATGTGGGTGGTCTCCCCGAAGACATGCAGTTTGAATTGATTGAGCCCTTAAACACTC
TTTTCAAAGATGAAGTTCGAGCGCTTGGAATCGCTCTTGGAATGCCTGAAGAAATTGTTTGGCGCCAACCATTTCCAGGT
CCTGGACTTGCTATCCGTGTCATGGGAGCAATTACTGAAGAAAAACTTGAAACCGTTCGCGAATCAGACGCTATCCTTCG
TGAAGAAATTGCTAAGGCTGGACTTGATCGTGACGTGTGGCAATACTTTACAGTTAACACAGGTGTCCGTTCTGTAGGCG
TCATGGGAGATGGTCGTACTTATGATTATACCATCGCCATTCGTGCTATTACGTCTATTGATGGTATGACAGCTGACTTT
GCTCAACTTCCTTGGGATGTCTTGAAAAAAATCTCAACACGTATCGTAAATGAAGTTGACCACGTTAACCGTATCGTCTA
CGACATCACAAGTAAACCACCCGCAACAGTTGAATGGGAATAA

Upstream 100 bases:

>100_bases
CCAACGAGCTAGAGAAATTGTAATGTCTTTTCGATGAAAATATGCTACAATAAGTTGACAACTATCAACCTGACGGTTGG
TATAGAATGAAAGGATTATA

Downstream 100 bases:

>100_bases
CAGAATAAACATTAAAAGACTCGCCAAAATGAGCGAGTCTTTTAATGTTTATTCTTTAACTGTTTTCGTATTTTGTACAT
GGTATTAGCAATATGATAAA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFE
LGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSND
CPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSV
VGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDE
ASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPG
PGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
AQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE

Sequences:

>Translated_520_residues
MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFE
LGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSND
CPYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSV
VGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDE
ASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPG
PGLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
AQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE
>Mature_519_residues
TEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLSGGPNSVYADNAFGIDPEIFEL
GIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLHLRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSNDC
PYAAIENTEKNLYGIQFHPEVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSVV
GVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVEDPEKKRKIIGNEFVYVFDDEA
SKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPGP
GLAIRVMGAITEEKLETVRESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADFA
QLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=550, Percent_Identity=36.3636363636364, Blast_Score=298, Evalue=9e-81,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=51.3409961685824, Blast_Score=540, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI71992717, Length=571, Percent_Identity=36.2521891418564, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71992710, Length=571, Percent_Identity=36.2521891418564, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI133901714, Length=571, Percent_Identity=36.2521891418564, Blast_Score=302, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6323873, Length=526, Percent_Identity=51.3307984790874, Blast_Score=515, Evalue=1e-147,
Organism=Drosophila melanogaster, GI281365319, Length=548, Percent_Identity=37.2262773722628, Blast_Score=303, Evalue=3e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57502; Mature: 57371

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLS
CCCCHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEE
GGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLH
CCCCCEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCEEE
LRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSNDCPYAAIENTEKNLYGIQFHP
HHHHHHHHCCCCHHEEEEEECCCHHHHCCCCEEEECCCCCCCCCEECCCCCCEEEEEECC
EVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSV
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVE
HHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC
DPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLP
CHHHHHHHCCCCEEEEECCCCCHHCCCHHHCCCCHHHHHHHCCHHHHHHHHHHCCCCCCC
EDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPGPGLAIRVMGAITEEKLETVR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHH
ESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
HHHHHHHHHHHHCCCCHHHHHHEEECCCCCEEEEECCCCEEEEEEEEEEEECCCCCCCHH
AQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE
HHCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC
>Mature Secondary Structure 
TEISILNDVQKIIVLDYGSQYNQLIARRIREFGVFSELKSHKITAQELREINPIGIVLS
CCCHHHHHCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEE
GGPNSVYADNAFGIDPEIFELGIPILGICYGMQLITHKLGGKVVPAGQAGNREYGQSTLH
CCCCCEECCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHCCCEEE
LRETSKLFSGTPQEQLVLMSHGDAVTEIPEGFHLVGDSNDCPYAAIENTEKNLYGIQFHP
HHHHHHHHCCCCHHEEEEEECCCHHHHCCCCEEEECCCCCCCCCEECCCCCCEEEEEECC
EVRHSVYGNDILKNFAISICGARGDWSMDNFIDMEIAKIRETVGDRKVLLGLSGGVDSSV
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHH
VGVLLQKAIGDQLTCIFVDHGLLRKDEGDQVMGMLGGKFGLNIIRVDASKRFLDLLADVE
HHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC
DPEKKRKIIGNEFVYVFDDEASKLKGVDFLAQGTLYTDIIESGTETAQTIKSHHNVGGLP
CHHHHHHHCCCCEEEEECCCCCHHCCCHHHCCCCHHHHHHHCCHHHHHHHHHHCCCCCCC
EDMQFELIEPLNTLFKDEVRALGIALGMPEEIVWRQPFPGPGLAIRVMGAITEEKLETVR
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHH
ESDAILREEIAKAGLDRDVWQYFTVNTGVRSVGVMGDGRTYDYTIAIRAITSIDGMTADF
HHHHHHHHHHHHCCCCHHHHHHEEECCCCCEEEEECCCCEEEEEEEEEEEECCCCCCCHH
AQLPWDVLKKISTRIVNEVDHVNRIVYDITSKPPATVEWE
HHCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA