Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
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Accession | NC_002737 |
Length | 1,852,441 |
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The map label for this gene is lepA [H]
Identifier: 15675045
GI number: 15675045
Start: 861900
End: 863732
Strand: Direct
Name: lepA [H]
Synonym: SPy_1053
Alternate gene names: 15675045
Gene position: 861900-863732 (Clockwise)
Preceding gene: 15675044
Following gene: 15675046
Centisome position: 46.53
GC content: 42.83
Gene sequence:
>1833_bases ATGAACAGTCAAGATTTAAAAAAACGTCAGGAGAAGATTCGTAATTTCTCCATTATCGCACATATTGACCATGGCAAATC TACTCTCGCTGACCGCATTTTGGAAAAGACAGAGACGGTTTCGTCTCGTGAAATGCAGGCTCAGTTATTGGACTCCATGG ATTTGGAGCGTGAGCGTGGGATTACCATCAAGTTAAACGCCATTGAGCTTAATTACACGGCTAAAGATGGGGAAACCTAC ATTTTCCACCTTATTGATACCCCAGGGCATGTGGACTTTACTTATGAAGTATCGCGTTCGTTGGCAGCCTGTGAGGGAGC GATTTTAGTTGTTGATGCAGCGCAGGGAATTGAAGCGCAGACATTGGCTAATGTTTACCTAGCCCTTGATAATGATTTGG AAATTTTACCGGTTATCAATAAAATTGATTTGCCTGCTGCTGACCCTGAGAGAGTCCGTCATGAAGTAGAAGATGTCATT GGACTTGATGCTTCTGAGGCTGTTCTGGCATCAGCCAAGGCTGGTATTGGGATCGAAGAGATTCTTGAGCAAATTGTTGA GAAGGTTCCTGCTCCTACGGGTGATGTGGATGCGCCTTTACAGGCCTTGATTTTTGACTCTGTGTATGATGCTTACCGAG GGGTAATTTTGCAGGTTCGGATTGTGAACGGTATTGTCAAGCCTGGCGATAAAATCCAGATGATGTCTAATGGAAAAACC TTTGATGTTACAGAAGTTGGGATTTTCACTCCTAAGGCAGTTGGACGAGATTTCCTTGCGACGGGAGATGTTGGTTATGT TGCGGCTTCTATCAAAACGGTAGCAGATACCCGTGTGGGGGATACGGTGACTTTAGCTAATAACCCTGCTAAGGAAGCCT TGCATGGCTACAAGCAGATGAACCCGATGGTCTTTGCAGGGATTTATCCGATTGAATCAAATAAATACAATGACTTGCGT GAAGCACTTGAAAAATTACAACTGAACGATGCCAGTTTACAGTTTGAACCCGAAACGTCACAAGCGCTTGGATTTGGTTT TCGATGCGGTTTTTTAGGCTTGCTTCACATGGATGTGATTCAAGAACGTTTGGAACGTGAATTTAACATTGATTTGATCA TGACAGCACCATCTGTAGTCTACCATGTTCACACAACAGATGAGGACATGATTGAAGTGTCTAACCCTTCAGAATTTCCA GACCCAACACGGGTGGCTTTTATTGAAGAGCCTTATGTTAAAGCGCAAATCATGGTGCCACAAGAGTTCGTAGGGGCTGT TATGGAATTATCGCAGCGCAAGCGTGGTGATTTTGTGACCATGGATTACATTGATGATAACCGTGTCAATGTGATCTACC AAATCCCGCTGGCTGAAATTGTGTTTGATTTCTTTGATAAATTGAAATCCTCAACGCGAGGCTATGCGAGTTTTGATTAT GACATGTCAGAATACCGCAGGTCACAATTGGTGAAAATGGACATTCTTTTGAACGGTGATAAGGTCGATGCGCTCAGCTT TATTGTTCATAAAGAATTTGCTTATGAACGCGGGAAAATTATTGTTGAGAAATTGAAAAAAATCATTCCACGTCAACAGT TTGAAGTTCCGATCCAAGCCGCTATTGGTCAAAAAATTGTTGCGCGTTCAGACATCAAGGCCCTTCGTAAAAACGTTTTA GCGAAGTGTTATGGTGGTGACGTGTCTCGTAAACGTAAATTGCTCGAAAAACAAAAGGCTGGTAAAAAACGGATGAAGGC TATTGGTTCTGTCGAAGTCCCTCAAGAAGCCTTCTTGAGTGTTCTTTCAATGGATGACGATACCAAGAAATAA
Upstream 100 bases:
>100_bases CTCCGCTATTCTCTTGCAAGATAATCCGTAAGAAAAGATAGGCAAAGGCCTACCTTTTTTGTTATAATAGAAGGAAAGAC TAAATGTATAGGAAAATAGA
Downstream 100 bases:
>100_bases CCAAGCCTAATCGCTTAGTCTTCAGAGGAGAACTCTTGTGGGTCTACATGACCAAAAAATGGTTATCTTATACAAAAAGA ACTTTACAATCATTCGCACA
Product: GTP-binding protein LepA
Products: NA
Alternate protein names: EF-4; Ribosomal back-translocase LepA [H]
Number of amino acids: Translated: 610; Mature: 610
Protein sequence:
>610_residues MNSQDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETY IFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRHEVEDVI GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKPGDKIQMMSNGKT FDVTEVGIFTPKAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNPAKEALHGYKQMNPMVFAGIYPIESNKYNDLR EALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVHTTDEDMIEVSNPSEFP DPTRVAFIEEPYVKAQIMVPQEFVGAVMELSQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDY DMSEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKIIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVL AKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDTKK
Sequences:
>Translated_610_residues MNSQDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETY IFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRHEVEDVI GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKPGDKIQMMSNGKT FDVTEVGIFTPKAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNPAKEALHGYKQMNPMVFAGIYPIESNKYNDLR EALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVHTTDEDMIEVSNPSEFP DPTRVAFIEEPYVKAQIMVPQEFVGAVMELSQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDY DMSEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKIIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVL AKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDTKK >Mature_610_residues MNSQDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERGITIKLNAIELNYTAKDGETY IFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPAADPERVRHEVEDVI GLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKPGDKIQMMSNGKT FDVTEVGIFTPKAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNPAKEALHGYKQMNPMVFAGIYPIESNKYNDLR EALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVYHVHTTDEDMIEVSNPSEFP DPTRVAFIEEPYVKAQIMVPQEFVGAVMELSQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDY DMSEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKIIVEKLKKIIPRQQFEVPIQAAIGQKIVARSDIKALRKNVL AKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLSVLSMDDDTKK
Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc
COG id: COG0481
COG function: function code M; Membrane GTPase LepA
Gene ontology:
Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily [H]
Homologues:
Organism=Homo sapiens, GI157426893, Length=600, Percent_Identity=50.1666666666667, Blast_Score=619, Evalue=1e-177, Organism=Homo sapiens, GI94966754, Length=148, Percent_Identity=44.5945945945946, Blast_Score=119, Evalue=7e-27, Organism=Homo sapiens, GI18390331, Length=162, Percent_Identity=37.037037037037, Blast_Score=104, Evalue=3e-22, Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=38.7755102040816, Blast_Score=104, Evalue=3e-22, Organism=Homo sapiens, GI310132016, Length=125, Percent_Identity=42.4, Blast_Score=100, Evalue=6e-21, Organism=Homo sapiens, GI310110807, Length=125, Percent_Identity=42.4, Blast_Score=100, Evalue=6e-21, Organism=Homo sapiens, GI310123363, Length=125, Percent_Identity=42.4, Blast_Score=100, Evalue=6e-21, Organism=Homo sapiens, GI217272892, Length=168, Percent_Identity=33.9285714285714, Blast_Score=97, Evalue=5e-20, Organism=Homo sapiens, GI217272894, Length=168, Percent_Identity=33.9285714285714, Blast_Score=97, Evalue=6e-20, Organism=Homo sapiens, GI25306283, Length=135, Percent_Identity=42.962962962963, Blast_Score=97, Evalue=6e-20, Organism=Homo sapiens, GI19923640, Length=135, Percent_Identity=42.962962962963, Blast_Score=97, Evalue=6e-20, Organism=Homo sapiens, GI25306287, Length=135, Percent_Identity=42.962962962963, Blast_Score=97, Evalue=6e-20, Organism=Homo sapiens, GI53729339, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=2e-15, Organism=Homo sapiens, GI53729337, Length=252, Percent_Identity=27.3809523809524, Blast_Score=82, Evalue=2e-15, Organism=Homo sapiens, GI34147630, Length=255, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=2e-13, Organism=Escherichia coli, GI1788922, Length=599, Percent_Identity=58.2637729549249, Blast_Score=723, Evalue=0.0, Organism=Escherichia coli, GI48994988, Length=505, Percent_Identity=31.2871287128713, Blast_Score=178, Evalue=7e-46, Organism=Escherichia coli, GI1789738, Length=183, Percent_Identity=34.4262295081967, Blast_Score=89, Evalue=8e-19, Organism=Escherichia coli, GI1790835, Length=225, Percent_Identity=28.8888888888889, Blast_Score=88, Evalue=1e-18, Organism=Escherichia coli, GI1789559, Length=255, Percent_Identity=29.4117647058824, Blast_Score=80, Evalue=3e-16, Organism=Escherichia coli, GI1790412, Length=265, Percent_Identity=27.9245283018868, Blast_Score=72, Evalue=1e-13, Organism=Escherichia coli, GI1789737, Length=265, Percent_Identity=27.9245283018868, Blast_Score=72, Evalue=1e-13, Organism=Escherichia coli, GI1789108, Length=158, Percent_Identity=29.1139240506329, Blast_Score=64, Evalue=3e-11, Organism=Caenorhabditis elegans, GI17557151, Length=612, Percent_Identity=42.8104575163399, Blast_Score=516, Evalue=1e-146, Organism=Caenorhabditis elegans, GI71988811, Length=181, Percent_Identity=35.3591160220994, Blast_Score=98, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=39.7260273972603, Blast_Score=98, Evalue=1e-20, Organism=Caenorhabditis elegans, GI71988819, Length=181, Percent_Identity=35.3591160220994, Blast_Score=98, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17556745, Length=161, Percent_Identity=34.7826086956522, Blast_Score=93, Evalue=4e-19, Organism=Caenorhabditis elegans, GI17506493, Length=162, Percent_Identity=34.5679012345679, Blast_Score=93, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17552882, Length=153, Percent_Identity=31.3725490196078, Blast_Score=86, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17556456, Length=268, Percent_Identity=31.7164179104478, Blast_Score=77, Evalue=4e-14, Organism=Caenorhabditis elegans, GI25141371, Length=243, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=8e-12, Organism=Caenorhabditis elegans, GI71994658, Length=148, Percent_Identity=30.4054054054054, Blast_Score=66, Evalue=5e-11, Organism=Saccharomyces cerevisiae, GI6323320, Length=600, Percent_Identity=44.8333333333333, Blast_Score=520, Evalue=1e-148, Organism=Saccharomyces cerevisiae, GI6323098, Length=185, Percent_Identity=37.8378378378378, Blast_Score=117, Evalue=5e-27, Organism=Saccharomyces cerevisiae, GI6324707, Length=153, Percent_Identity=38.562091503268, Blast_Score=106, Evalue=9e-24, Organism=Saccharomyces cerevisiae, GI6320593, Length=153, Percent_Identity=38.562091503268, Blast_Score=106, Evalue=9e-24, Organism=Saccharomyces cerevisiae, GI6322359, Length=153, Percent_Identity=37.2549019607843, Blast_Score=92, Evalue=3e-19, Organism=Saccharomyces cerevisiae, GI6324166, Length=141, Percent_Identity=36.1702127659575, Blast_Score=81, Evalue=5e-16, Organism=Saccharomyces cerevisiae, GI6324761, Length=258, Percent_Identity=28.2945736434109, Blast_Score=79, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6322675, Length=141, Percent_Identity=29.0780141843972, Blast_Score=68, Evalue=3e-12, Organism=Drosophila melanogaster, GI78706572, Length=600, Percent_Identity=43.8333333333333, Blast_Score=523, Evalue=1e-148, Organism=Drosophila melanogaster, GI24582462, Length=186, Percent_Identity=39.247311827957, Blast_Score=105, Evalue=7e-23, Organism=Drosophila melanogaster, GI28574573, Length=144, Percent_Identity=41.6666666666667, Blast_Score=102, Evalue=1e-21, Organism=Drosophila melanogaster, GI24585709, Length=154, Percent_Identity=33.7662337662338, Blast_Score=94, Evalue=2e-19, Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=33.7748344370861, Blast_Score=94, Evalue=3e-19, Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=33.7748344370861, Blast_Score=94, Evalue=3e-19, Organism=Drosophila melanogaster, GI221458488, Length=161, Percent_Identity=38.5093167701863, Blast_Score=91, Evalue=2e-18, Organism=Drosophila melanogaster, GI21357743, Length=170, Percent_Identity=32.9411764705882, Blast_Score=89, Evalue=9e-18, Organism=Drosophila melanogaster, GI281363316, Length=270, Percent_Identity=27.4074074074074, Blast_Score=82, Evalue=1e-15, Organism=Drosophila melanogaster, GI17864358, Length=270, Percent_Identity=27.4074074074074, Blast_Score=82, Evalue=1e-15, Organism=Drosophila melanogaster, GI19921738, Length=230, Percent_Identity=30, Blast_Score=70, Evalue=4e-12, Organism=Drosophila melanogaster, GI28572034, Length=225, Percent_Identity=28, Blast_Score=69, Evalue=1e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR009022 - InterPro: IPR006297 - InterPro: IPR013842 - InterPro: IPR000795 - InterPro: IPR005225 - InterPro: IPR000640 - InterPro: IPR004161 - InterPro: IPR009000 [H]
Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C [H]
EC number: NA
Molecular weight: Translated: 68192; Mature: 68192
Theoretical pI: Translated: 4.92; Mature: 4.92
Prosite motif: PS00301 EFACTOR_GTP
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.8 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNSQDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERG CCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC ITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQ EEEEEEEEEEEEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCHH TLANVYLALDNDLEILPVINKIDLPAADPERVRHEVEDVIGLDASEAVLASAKAGIGIEE HHEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHH ILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKPGDKIQMMSNGKT HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEEEECCCCE FDVTEVGIFTPKAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNPAKEALHGYKQM EEEEEECCCCCHHHCCCCEECCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHC NPMVFAGIYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVI CCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHCCCHHHHHHHHHHHHHH QERLEREFNIDLIMTAPSVVYHVHTTDEDMIEVSNPSEFPDPTRVAFIEEPYVKAQIMVP HHHHHHHCCEEEEEECCEEEEEEECCCCCEEEECCCCCCCCCCEEEEEECCCEEEEEECC QEFVGAVMELSQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDY HHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEECC DMSEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKIIVEKLKKIIPRQQFEVPIQA CHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH AIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLS HHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH VLSMDDDTKK HHCCCCCCCC >Mature Secondary Structure MNSQDLKKRQEKIRNFSIIAHIDHGKSTLADRILEKTETVSSREMQAQLLDSMDLERERG CCCHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC ITIKLNAIELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQ EEEEEEEEEEEEEECCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCCEEEEECCCCCCHH TLANVYLALDNDLEILPVINKIDLPAADPERVRHEVEDVIGLDASEAVLASAKAGIGIEE HHEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHH ILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKPGDKIQMMSNGKT HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCEEEEECCCCE FDVTEVGIFTPKAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNPAKEALHGYKQM EEEEEECCCCCHHHCCCCEECCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHC NPMVFAGIYPIESNKYNDLREALEKLQLNDASLQFEPETSQALGFGFRCGFLGLLHMDVI CCEEEEEEEECCCCCHHHHHHHHHHHCCCCCCEEECCCCHHHHCCCHHHHHHHHHHHHHH QERLEREFNIDLIMTAPSVVYHVHTTDEDMIEVSNPSEFPDPTRVAFIEEPYVKAQIMVP HHHHHHHCCEEEEEECCEEEEEEECCCCCEEEECCCCCCCCCCEEEEEECCCEEEEEECC QEFVGAVMELSQRKRGDFVTMDYIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDY HHHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCHHHHHHHHHHHHHHCCCCCEEECC DMSEYRRSQLVKMDILLNGDKVDALSFIVHKEFAYERGKIIVEKLKKIIPRQQFEVPIQA CHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHH AIGQKIVARSDIKALRKNVLAKCYGGDVSRKRKLLEKQKAGKKRMKAIGSVEVPQEAFLS HHCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH VLSMDDDTKK HHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA