Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is 15675021

Identifier: 15675021

GI number: 15675021

Start: 829392

End: 831053

Strand: Direct

Name: 15675021

Synonym: SPy_1020

Alternate gene names: NA

Gene position: 829392-831053 (Clockwise)

Preceding gene: 15675020

Following gene: 15675022

Centisome position: 44.77

GC content: 38.45

Gene sequence:

>1662_bases
ATGACTGATATTAAAATGATTGCCTTGGGAGGGGTCCGTGAATACGGAAAAAACTTCTATTTGGTAGAAATTAACGATTC
TATGTTTATTTTAGACGCAGGGCTCAAGTACCCTGAAAATGAGCAACTTGGGGTAGATTTAGTCATCCCCAATTTAGATT
ATGTAATTGAAAACAAAGGTAAAGTACAAGGGATTTTCTTGAGTCATGGCCATGCTGACGCCATTGGAGCCCTTCCTTAT
TTGTTAGCTGAAGTATCAGCTCCTGTATTTGGATCTGAATTGACTATTGAATTAGCCAAGCTATTTGTGAAAAGTAATAA
CAGCACTAAGAAATTTAATAATTTTCATGTGGTAGACAGTGATACTGAAATTGAATTTAAAGATGGCCTAGTTTCGTTCT
TTAGAACAACGCATTCAATCCCAGAAAGTATGGGTATTGTTATTGGAACAGATAAAGGAAACATTATTTATACCGGTGAC
TTCAAATTTGATCAAGCAGCAAGAGAAGGTTATCAGACGGATTTGCTACGTTTAGCTGAGATTGGGAAAGAAGGGGTTCT
AGCTCTTTTATCAGATTCAGTCAATGCGACAAGCAACGATCAGATTGCCAGCGAATCTGAAGTTGGTGAAGAAATGGACA
GTGTTATCTCTGATGCTGATGGCCGTGTCATTGTAGCTGCAGTAGCCTCAAATCTTGTTCGGATTCAGCAAGTATTTGAT
TCCGCCACTGCCCATGGGCGTCGTGTTGTTTTAACCGGAACAGATGCAGAAAATATTGTCAGAACAGCTTTACGTCTAGA
AAAATTAATGATTACGGATGAGCGTCTTTTAATTAAACCTAAGGATATGTCTAAATTCGAAGACCATGAATTAATCATCC
TTGAAGCTGGTCGTATGGGTGAGCCAATTAATAGCTTACAAAAAATGGCAGCGGGACGTCACCGTTATGTTCAAATCAAA
GAAGGAGACCTTGTTTATATTGTAACAACACCAAGTACGGCTAAAGAAGCTATGGTGGCGCGTGTTGAAAACTTGATTTA
CAAGGCCGGTGGTTCTGTTAAATTAATCACTCAAAACTTACGTGTTTCAGGCCATGCTAATGGGCGTGATTTGCAACTAT
TGATGAATTTGTTAAAACCCCAGTATCTTTTTCCAGTACAAGGAGAATATCGTGATTTAGCTGCCCATGCAAAGCTAGCT
GAAGAAGTTGGTATTTTTCCAGAGAATATTCATATTCTGAAGCGTGGCGATATCATGGTGCTTAATGACGAAGGTTTTCT
CCATGAAGGAGGTGTACCTGCCAGTGATGTCATGATTGACGGTAATGCTATCGGTGATGTGGGTAATATCGTTTTACGAG
ACCGTAAAGTCTTGTCAGAAGATGGTATTTTCATTGTTGCTATTACTGTTTCTAAAAAAGAAAAACGCATTATTTCTAAG
GCTAAAGTTAATACGCGTGGATTTGTGTATGTCAAGAAAAGTCATGATATTTTAAGAGAAAGTGCAGAATTAGTTAATAC
AACTGTTGGCAATTACTTAAAAAAAGATACCTTTGACTGGGGCGAATTAAAAGGGAATGTCAGAGATGATTTGTCTAAAT
TCTTATTTGAACAAACCAAAAGGCGCCCAGCGATTCTGCCGGTTGTGATGGAAGTTCGTTAG

Upstream 100 bases:

>100_bases
AATATGATATACTATAGAAGATAGTAGCATAGCTACATAACAGTAATTCGACTTACGTTGTAAGGACCGTTTGTAATAAT
AAAATATTTAAAGGAGTATC

Downstream 100 bases:

>100_bases
TGAAAATAGGAAGGTTAGGCAAAAACTGCCTACCTTCTTTGATTTTAACAACTGGTAAACCAGGAAACTGTTCACCCAAA
AATACAGTAGATTTACGTGA

Product: Zn-dependent hydrolase

Products: NA

Alternate protein names: RNase J2 [H]

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MTDIKMIALGGVREYGKNFYLVEINDSMFILDAGLKYPENEQLGVDLVIPNLDYVIENKGKVQGIFLSHGHADAIGALPY
LLAEVSAPVFGSELTIELAKLFVKSNNSTKKFNNFHVVDSDTEIEFKDGLVSFFRTTHSIPESMGIVIGTDKGNIIYTGD
FKFDQAAREGYQTDLLRLAEIGKEGVLALLSDSVNATSNDQIASESEVGEEMDSVISDADGRVIVAAVASNLVRIQQVFD
SATAHGRRVVLTGTDAENIVRTALRLEKLMITDERLLIKPKDMSKFEDHELIILEAGRMGEPINSLQKMAAGRHRYVQIK
EGDLVYIVTTPSTAKEAMVARVENLIYKAGGSVKLITQNLRVSGHANGRDLQLLMNLLKPQYLFPVQGEYRDLAAHAKLA
EEVGIFPENIHILKRGDIMVLNDEGFLHEGGVPASDVMIDGNAIGDVGNIVLRDRKVLSEDGIFIVAITVSKKEKRIISK
AKVNTRGFVYVKKSHDILRESAELVNTTVGNYLKKDTFDWGELKGNVRDDLSKFLFEQTKRRPAILPVVMEVR

Sequences:

>Translated_553_residues
MTDIKMIALGGVREYGKNFYLVEINDSMFILDAGLKYPENEQLGVDLVIPNLDYVIENKGKVQGIFLSHGHADAIGALPY
LLAEVSAPVFGSELTIELAKLFVKSNNSTKKFNNFHVVDSDTEIEFKDGLVSFFRTTHSIPESMGIVIGTDKGNIIYTGD
FKFDQAAREGYQTDLLRLAEIGKEGVLALLSDSVNATSNDQIASESEVGEEMDSVISDADGRVIVAAVASNLVRIQQVFD
SATAHGRRVVLTGTDAENIVRTALRLEKLMITDERLLIKPKDMSKFEDHELIILEAGRMGEPINSLQKMAAGRHRYVQIK
EGDLVYIVTTPSTAKEAMVARVENLIYKAGGSVKLITQNLRVSGHANGRDLQLLMNLLKPQYLFPVQGEYRDLAAHAKLA
EEVGIFPENIHILKRGDIMVLNDEGFLHEGGVPASDVMIDGNAIGDVGNIVLRDRKVLSEDGIFIVAITVSKKEKRIISK
AKVNTRGFVYVKKSHDILRESAELVNTTVGNYLKKDTFDWGELKGNVRDDLSKFLFEQTKRRPAILPVVMEVR
>Mature_552_residues
TDIKMIALGGVREYGKNFYLVEINDSMFILDAGLKYPENEQLGVDLVIPNLDYVIENKGKVQGIFLSHGHADAIGALPYL
LAEVSAPVFGSELTIELAKLFVKSNNSTKKFNNFHVVDSDTEIEFKDGLVSFFRTTHSIPESMGIVIGTDKGNIIYTGDF
KFDQAAREGYQTDLLRLAEIGKEGVLALLSDSVNATSNDQIASESEVGEEMDSVISDADGRVIVAAVASNLVRIQQVFDS
ATAHGRRVVLTGTDAENIVRTALRLEKLMITDERLLIKPKDMSKFEDHELIILEAGRMGEPINSLQKMAAGRHRYVQIKE
GDLVYIVTTPSTAKEAMVARVENLIYKAGGSVKLITQNLRVSGHANGRDLQLLMNLLKPQYLFPVQGEYRDLAAHAKLAE
EVGIFPENIHILKRGDIMVLNDEGFLHEGGVPASDVMIDGNAIGDVGNIVLRDRKVLSEDGIFIVAITVSKKEKRIISKA
KVNTRGFVYVKKSHDILRESAELVNTTVGNYLKKDTFDWGELKGNVRDDLSKFLFEQTKRRPAILPVVMEVR

Specific function: Unknown

COG id: COG0595

COG function: function code R; Predicted hydrolase of the metallo-beta-lactamase superfamily

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. RNase J subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR011108
- InterPro:   IPR004613 [H]

Pfam domain/function: PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 61194; Mature: 61063

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIKMIALGGVREYGKNFYLVEINDSMFILDAGLKYPENEQLGVDLVIPNLDYVIENKG
CCCEEEEEECCHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEEEEEECCCCEEECCCC
KVQGIFLSHGHADAIGALPYLLAEVSAPVFGSELTIELAKLFVKSNNSTKKFNNFHVVDS
CEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECC
DTEIEFKDGLVSFFRTTHSIPESMGIVIGTDKGNIIYTGDFKFDQAAREGYQTDLLRLAE
CCCEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCCCCHHHHCCHHHHHHHHHH
IGKEGVLALLSDSVNATSNDQIASESEVGEEMDSVISDADGRVIVAAVASNLVRIQQVFD
CCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
SATAHGRRVVLTGTDAENIVRTALRLEKLMITDERLLIKPKDMSKFEDHELIILEAGRMG
HHHCCCCEEEEECCCHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCEEEEECCCCC
EPINSLQKMAAGRHRYVQIKEGDLVYIVTTPSTAKEAMVARVENLIYKAGGSVKLITQNL
CCHHHHHHHHCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
RVSGHANGRDLQLLMNLLKPQYLFPVQGEYRDLAAHAKLAEEVGIFPENIHILKRGDIMV
EEECCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCEEE
LNDEGFLHEGGVPASDVMIDGNAIGDVGNIVLRDRKVLSEDGIFIVAITVSKKEKRIISK
ECCCCCEECCCCCHHHEEECCCCCCCCCCEEEECCHHHCCCCEEEEEEEECCHHHHHHHH
AKVNTRGFVYVKKSHDILRESAELVNTTVGNYLKKDTFDWGELKGNVRDDLSKFLFEQTK
HCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHC
RRPAILPVVMEVR
CCCCEEEEEEEEC
>Mature Secondary Structure 
TDIKMIALGGVREYGKNFYLVEINDSMFILDAGLKYPENEQLGVDLVIPNLDYVIENKG
CCEEEEEECCHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEEEEEECCCCEEECCCC
KVQGIFLSHGHADAIGALPYLLAEVSAPVFGSELTIELAKLFVKSNNSTKKFNNFHVVDS
CEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECC
DTEIEFKDGLVSFFRTTHSIPESMGIVIGTDKGNIIYTGDFKFDQAAREGYQTDLLRLAE
CCCEEHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCCCCCHHHHCCHHHHHHHHHH
IGKEGVLALLSDSVNATSNDQIASESEVGEEMDSVISDADGRVIVAAVASNLVRIQQVFD
CCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHH
SATAHGRRVVLTGTDAENIVRTALRLEKLMITDERLLIKPKDMSKFEDHELIILEAGRMG
HHHCCCCEEEEECCCHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCCEEEEECCCCC
EPINSLQKMAAGRHRYVQIKEGDLVYIVTTPSTAKEAMVARVENLIYKAGGSVKLITQNL
CCHHHHHHHHCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEE
RVSGHANGRDLQLLMNLLKPQYLFPVQGEYRDLAAHAKLAEEVGIFPENIHILKRGDIMV
EEECCCCCHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCEEE
LNDEGFLHEGGVPASDVMIDGNAIGDVGNIVLRDRKVLSEDGIFIVAITVSKKEKRIISK
ECCCCCEECCCCCHHHEEECCCCCCCCCCEEEECCHHHCCCCEEEEEEEECCHHHHHHHH
AKVNTRGFVYVKKSHDILRESAELVNTTVGNYLKKDTFDWGELKGNVRDDLSKFLFEQTK
HCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHC
RRPAILPVVMEVR
CCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA