Definition | Streptococcus pyogenes M1 GAS chromosome, complete genome. |
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Accession | NC_002737 |
Length | 1,852,441 |
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The map label for this gene is nth [H]
Identifier: 15674949
GI number: 15674949
Start: 772406
End: 773062
Strand: Direct
Name: nth [H]
Synonym: SPy_0929
Alternate gene names: 15674949
Gene position: 772406-773062 (Clockwise)
Preceding gene: 15674948
Following gene: 15674950
Centisome position: 41.7
GC content: 40.03
Gene sequence:
>657_bases ATGAGAATTGGAAAAGCAAGATTAGCAAAAGTCCTGACCATCATTGGTCAAATGTTTCCTGAGGCTAAGGGAGAGTTAGA CTGGGAAACACCTTTTCAATTGTTGATTGCGGTGATTTTATCAGCTCAAACGACAGATAAGGCCGTCAATAAGGTAACTC CTGGACTATGGCAGTCTTATCCAGAAATAGAAGACTTAGCTTTTGCTGAACTTTCTGATGTTGAAAATGCTCTGAGAACG ATTGGACTCTATAAAAATAAGGCCAAAAATATCATTAAAACTGCTCAGGCTATTCGTGATGATTTTAAGGGTCAAGTGCC AAAAACCCACAAAGAGCTTGAAAGTTTACCGGGTGTTGGCCGAAAAACAGCCAATGTGGTGCTGGCAGAGGTTTATGGTG TTCCAGCTATTGCGGTTGATACTCATGTGGCTAGAGTCTCAAAGAGGCTCAATATTTCATCGCCAGATGCCGATGTCAAG CAGATTGAAGCAGATTTGATGGCTAAAATTCCAAAGAAAGATTGGATTATTACTCACCATCGATTGATTTTTTTTGGACG CTACCATTGTTTAGCCAAAAAACCAAAATGTGAGATTTGTCCCGTTCAGTCTTACTGCAAGTACTATCAAGATACTTATG GAAAATCGAAAGCCTAG
Upstream 100 bases:
>100_bases GACAAGTAGAAGAACGTAGACGTGTTAGAGAAGGCGAAGATCTTTCTCAAGTGACGATATCAGAGGATTTTCTATCTGCG ATGAATTTATGGAGTGATTC
Downstream 100 bases:
>100_bases CCTTTGGTTTTCTTTTTTTATGGAGGTAATTTTGCTATAATAGAACCATTACGTTTTAGAAAGAAATCAAGATGGATAGT CAATTATCAAACCGTTTGGC
Product: putative endonuclease III
Products: NA
Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]
Number of amino acids: Translated: 218; Mature: 218
Protein sequence:
>218_residues MRIGKARLAKVLTIIGQMFPEAKGELDWETPFQLLIAVILSAQTTDKAVNKVTPGLWQSYPEIEDLAFAELSDVENALRT IGLYKNKAKNIIKTAQAIRDDFKGQVPKTHKELESLPGVGRKTANVVLAEVYGVPAIAVDTHVARVSKRLNISSPDADVK QIEADLMAKIPKKDWIITHHRLIFFGRYHCLAKKPKCEICPVQSYCKYYQDTYGKSKA
Sequences:
>Translated_218_residues MRIGKARLAKVLTIIGQMFPEAKGELDWETPFQLLIAVILSAQTTDKAVNKVTPGLWQSYPEIEDLAFAELSDVENALRT IGLYKNKAKNIIKTAQAIRDDFKGQVPKTHKELESLPGVGRKTANVVLAEVYGVPAIAVDTHVARVSKRLNISSPDADVK QIEADLMAKIPKKDWIITHHRLIFFGRYHCLAKKPKCEICPVQSYCKYYQDTYGKSKA >Mature_218_residues MRIGKARLAKVLTIIGQMFPEAKGELDWETPFQLLIAVILSAQTTDKAVNKVTPGLWQSYPEIEDLAFAELSDVENALRT IGLYKNKAKNIIKTAQAIRDDFKGQVPKTHKELESLPGVGRKTANVVLAEVYGVPAIAVDTHVARVSKRLNISSPDADVK QIEADLMAKIPKKDWIITHHRLIFFGRYHCLAKKPKCEICPVQSYCKYYQDTYGKSKA
Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da
COG id: COG0177
COG function: function code L; Predicted EndoIII-related endonuclease
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the Nth/MutY family [H]
Homologues:
Organism=Homo sapiens, GI4505471, Length=185, Percent_Identity=29.1891891891892, Blast_Score=90, Evalue=1e-18, Organism=Homo sapiens, GI6912520, Length=185, Percent_Identity=25.9459459459459, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI115298648, Length=185, Percent_Identity=25.9459459459459, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI190358497, Length=185, Percent_Identity=25.9459459459459, Blast_Score=72, Evalue=3e-13, Organism=Homo sapiens, GI115298650, Length=185, Percent_Identity=25.9459459459459, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI115298654, Length=185, Percent_Identity=25.9459459459459, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI115298652, Length=185, Percent_Identity=25.9459459459459, Blast_Score=72, Evalue=4e-13, Organism=Escherichia coli, GI1787920, Length=206, Percent_Identity=42.7184466019417, Blast_Score=173, Evalue=1e-44, Organism=Escherichia coli, GI1789331, Length=188, Percent_Identity=29.2553191489362, Blast_Score=80, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17554540, Length=179, Percent_Identity=37.4301675977654, Blast_Score=110, Evalue=4e-25, Organism=Saccharomyces cerevisiae, GI6324530, Length=187, Percent_Identity=28.8770053475936, Blast_Score=81, Evalue=1e-16, Organism=Saccharomyces cerevisiae, GI6319304, Length=174, Percent_Identity=29.8850574712644, Blast_Score=67, Evalue=2e-12, Organism=Drosophila melanogaster, GI45550361, Length=184, Percent_Identity=30.4347826086957, Blast_Score=92, Evalue=2e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011257 - InterPro: IPR004036 - InterPro: IPR005759 - InterPro: IPR004035 - InterPro: IPR003651 - InterPro: IPR003265 - InterPro: IPR000445 - InterPro: IPR003583 - InterPro: IPR023170 [H]
Pfam domain/function: PF00633 HHH; PF00730 HhH-GPD [H]
EC number: =4.2.99.18 [H]
Molecular weight: Translated: 24424; Mature: 24424
Theoretical pI: Translated: 9.73; Mature: 9.73
Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.8 %Cys (Translated Protein) 1.4 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 1.8 %Cys (Mature Protein) 1.4 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRIGKARLAKVLTIIGQMFPEAKGELDWETPFQLLIAVILSAQTTDKAVNKVTPGLWQSY CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHCC PEIEDLAFAELSDVENALRTIGLYKNKAKNIIKTAQAIRDDFKGQVPKTHKELESLPGVG CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC RKTANVVLAEVYGVPAIAVDTHVARVSKRLNISSPDADVKQIEADLMAKIPKKDWIITHH CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHH RLIFFGRYHCLAKKPKCEICPVQSYCKYYQDTYGKSKA HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC >Mature Secondary Structure MRIGKARLAKVLTIIGQMFPEAKGELDWETPFQLLIAVILSAQTTDKAVNKVTPGLWQSY CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCHHHHCC PEIEDLAFAELSDVENALRTIGLYKNKAKNIIKTAQAIRDDFKGQVPKTHKELESLPGVG CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC RKTANVVLAEVYGVPAIAVDTHVARVSKRLNISSPDADVKQIEADLMAKIPKKDWIITHH CHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEEHH RLIFFGRYHCLAKKPKCEICPVQSYCKYYQDTYGKSKA HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7704260; 8760912; 9384377 [H]