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The map label for this gene is apt

Identifier: 15674947

GI number: 15674947

Start: 771127

End: 771645

Strand: Direct

Name: apt

Synonym: SPy_0927

Alternate gene names: 15674947

Gene position: 771127-771645 (Clockwise)

Preceding gene: 15674946

Following gene: 15674948

Centisome position: 41.63

GC content: 38.73

Gene sequence:

>519_bases
ATGGATTTAACAAATTACATTGCATCGATCAAAGATTACCCTAAAGCTGGTATTACGTTTCGAGATATCTCACCTTTAAT
GGCTGACGGTAAAGCATATAGCTATGCTATTCGTGAAATAGCACAGTACGCTTGTGATAAAGATATTGATATGGTTGTTG
GACCTGAAGCGCGTGGTTTTATCATTGGTTGTCCTGTTGCAGTTGAGTTAGGAATTGGTTTTGCTCCCGTTCGTAAACCA
GGAAAACTGCCAAGAGATGTTGTCTCTGCCGATTACGAAAAAGAATATGGTCTTGATACTTTAACTATGCATGCAGATGC
TATTAAGCCTGGACAACGTGTTTTGATTGTCGATGATTTACTAGCGACTGGCGGTACAGTAAAAGCAACTATTGAAATGA
TTGAAAAACTTGGTGGTATTGTAGCTGGTTGTGCCTTCCTTATTGAATTAGAAGGTTTAAATGGACGCCATGCTATTAGG
AACTATGACTATAAAGTCTTAATGCAGTTTCCTGGGTAA

Upstream 100 bases:

>100_bases
TAAACAATAATGTCAGAAGTCTTATTTTACGAAAAATATGTTTCGTGATATAATGAAGAGTATTTTATATTTGGCAATTT
GCCACTAGAAAGAATTAACT

Downstream 100 bases:

>100_bases
ACACATTAATCAGCATCTGATTAGGGGATTTAAAGTAGTAAAGGCTATAGATTCGATTTTAGCCTTTTGATTGAGGGATT
ATGAGTTTTTTAGAACATTA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 172; Mature: 172

Protein sequence:

>172_residues
MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYACDKDIDMVVGPEARGFIIGCPVAVELGIGFAPVRKP
GKLPRDVVSADYEKEYGLDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGIVAGCAFLIELEGLNGRHAIR
NYDYKVLMQFPG

Sequences:

>Translated_172_residues
MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYACDKDIDMVVGPEARGFIIGCPVAVELGIGFAPVRKP
GKLPRDVVSADYEKEYGLDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGIVAGCAFLIELEGLNGRHAIR
NYDYKVLMQFPG
>Mature_172_residues
MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYACDKDIDMVVGPEARGFIIGCPVAVELGIGFAPVRKP
GKLPRDVVSADYEKEYGLDTLTMHADAIKPGQRVLIVDDLLATGGTVKATIEMIEKLGGIVAGCAFLIELEGLNGRHAIR
NYDYKVLMQFPG

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=169, Percent_Identity=40.8284023668639, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI71773201, Length=123, Percent_Identity=43.9024390243902, Blast_Score=101, Evalue=3e-22,
Organism=Escherichia coli, GI1786675, Length=175, Percent_Identity=53.1428571428571, Blast_Score=180, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=41.7647058823529, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=171, Percent_Identity=36.2573099415205, Blast_Score=102, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320649, Length=160, Percent_Identity=30.625, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136334, Length=164, Percent_Identity=44.5121951219512, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_STRP1 (P63546)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269121.1
- RefSeq:   YP_282091.1
- ProteinModelPortal:   P63546
- SMR:   P63546
- EnsemblBacteria:   EBSTRT00000000925
- EnsemblBacteria:   EBSTRT00000028637
- GeneID:   3572171
- GeneID:   901080
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0927
- KEGG:   spz:M5005_Spy_0728
- GeneTree:   EBGT00050000026782
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   SPYO160490:SPY0927-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0728-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18687; Mature: 18687

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYACDKDIDMVVGPEARGF
CCHHHHHHHHHCCCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCE
IIGCPVAVELGIGFAPVRKPGKLPRDVVSADYEKEYGLDTLTMHADAIKPGQRVLIVDDL
EEECCEEEEECCCCCCCCCCCCCCHHHHHCCCHHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKATIEMIEKLGGIVAGCAFLIELEGLNGRHAIRNYDYKVLMQFPG
HHCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCCEEEEEECCC
>Mature Secondary Structure
MDLTNYIASIKDYPKAGITFRDISPLMADGKAYSYAIREIAQYACDKDIDMVVGPEARGF
CCHHHHHHHHHCCCCCCCCHHCCCHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCE
IIGCPVAVELGIGFAPVRKPGKLPRDVVSADYEKEYGLDTLTMHADAIKPGQRVLIVDDL
EEECCEEEEECCCCCCCCCCCCCCHHHHHCCCHHHCCCCEEEEECCCCCCCCEEEEEEHH
LATGGTVKATIEMIEKLGGIVAGCAFLIELEGLNGRHAIRNYDYKVLMQFPG
HHCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296