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The map label for this gene is lsp

Identifier: 15674864

GI number: 15674864

Start: 678623

End: 679081

Strand: Direct

Name: lsp

Synonym: SPy_0826

Alternate gene names: 15674864

Gene position: 678623-679081 (Clockwise)

Preceding gene: 15674863

Following gene: 15674865

Centisome position: 36.63

GC content: 35.73

Gene sequence:

>459_bases
ATGAAAAAACGATTGTTTGTGCTTAGCTTGATCCTCCTTGTAGCTTTGGATCAACTTAGTAAATTTTGGATTGTTTCTCA
TATAGCGCTTGGAGAAGTGAAACCCTTTATCCCAGGTATCGTCAGCTTGACTTACTTGCAAAACAATGGGGCTGCCTTTT
CCATATTGCAGGACCAGCAATGGTTCTTTGTTGTCATAACGGTTTTAGTTATCGGTTATGCTATTTATTACCTTGCTACT
CATCCCCATTTAAATATCTGGAAACAATTAGCTCTCTTGCTTATTATTTCTGGTGGAATCGGGAATTTTATTGATCGTTT
GCGTTTAGCTTACGTGATTGATATGATTCATTTAGACTTTGTGGATTTTGCCATTTTTAATGTGGCAGATTCATACCTTA
CCGTTGGTGTCATATTATTATTGATATGTTTATGGAAAGAAGAGGATTATGGAAATTAA

Upstream 100 bases:

>100_bases
TGATTTATGTCAAACGAAAAGATAAAAACCTTTCTGTTGCTGGGGCCACTTTTGTGACTATTTTAAAAGACTATTTTGAT
AAAAGAAGGAAGGCCTTAAC

Downstream 100 bases:

>100_bases
TGTGATAACATCGGGGCAACGCTTGGATAAGGCACTAGCTGATTTAAGTCCCCTGTCACGTGGTCAAGCCAATGACCAAA
TTAAGCAAGGCCTTGTTTTA

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLAT
HPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFVDFAIFNVADSYLTVGVILLLICLWKEEDYGN

Sequences:

>Translated_152_residues
MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLAT
HPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFVDFAIFNVADSYLTVGVILLLICLWKEEDYGN
>Mature_152_residues
MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQWFFVVITVLVIGYAIYYLAT
HPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDFVDFAIFNVADSYLTVGVILLLICLWKEEDYGN

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=142, Percent_Identity=35.9154929577465, Blast_Score=75, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_STRP1 (Q9A0D2)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_269038.1
- RefSeq:   YP_282000.1
- EnsemblBacteria:   EBSTRT00000000635
- EnsemblBacteria:   EBSTRT00000028306
- GeneID:   3572266
- GeneID:   900995
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0826
- KEGG:   spz:M5005_Spy_0637
- GeneTree:   EBGT00050000027710
- HOGENOM:   HBG724422
- OMA:   ADSSGWQ
- ProtClustDB:   PRK14797
- BioCyc:   SPYO160490:SPY0826-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0637-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 17300; Mature: 17300

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 105-105 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

HASH(0xce729ac)-; HASH(0xb5e9ed8)-; HASH(0xd40a2bc)-; HASH(0xcbe755c)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCEEEEECCCC
WFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDF
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VDFAIFNVADSYLTVGVILLLICLWKEEDYGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MKKRLFVLSLILLVALDQLSKFWIVSHIALGEVKPFIPGIVSLTYLQNNGAAFSILQDQQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHEEEEEECCCCEEEEECCCC
WFFVVITVLVIGYAIYYLATHPHLNIWKQLALLLIISGGIGNFIDRLRLAYVIDMIHLDF
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
VDFAIFNVADSYLTVGVILLLICLWKEEDYGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11296296