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The map label for this gene is murA1

Identifier: 15674811

GI number: 15674811

Start: 621629

End: 622900

Strand: Direct

Name: murA1

Synonym: SPy_0763

Alternate gene names: 15674811

Gene position: 621629-622900 (Clockwise)

Preceding gene: 15674810

Following gene: 15674812

Centisome position: 33.56

GC content: 41.27

Gene sequence:

>1272_bases
GTGGATAAAATAATCATTGAAGGTGGTCAAACACGCTTAGAAGGAGAAGTTGTTATTGAGGGTGCTAAAAACGCAGTTCT
TCCTTTACTGGCAGCATCTATTTTACCTTCAAAAGGAAAAACAATTCTTAGAAACGTTCCTATTCTATCTGATGTTTTTA
CCATGAATAACGTGGTACGTGGTTTAGATATTCGTGTTGATTTTAATGAAGCAGCTAACGAAATCACAGTTGATGCCTCA
GGACACATTTTAGATGAAGCCCCTTACGAGTACGTGAGCCAAATGCGTGCCTCTATTGTTGTTTTAGGACCAATTTTGGC
ACGTAATGGCCACGCAAAAGTATCAATGCCTGGAGGCTGTACGATTGGCAGTAGGCCTATTAATTTGCACTTAAAAGGAT
TAGAGGCTATGGGGGCAACGATTACTCAAAAAGGTGGAGATATTACCGCTCAAGCAGATCGACTGCAAGGTGCCATGATT
TATATGGACTTCCCATCTGTAGGAGCTACCCAAAACTTGATGATGGCTGCCACTTTAGCTGATGGTGTGACCACTATTGA
AAATGCTGCTCGTGAGCCTGAAATTGTTGATTTAGCTCAATTTTTGAATAAAATGGGAGCTAGAATTCGTGGTGCTGGAA
CAGAGACGTTAACGATAACAGGTGTCACGCATTTACGAGGCGTAGAACATGATGTTGTTCAAGATCGTATAGAAGCCGGT
ACATTTATGGTTGCAGCGGCGATGACTTCAGGCAATGTTTTGATTAGAGATGCTGTTTGGGAACATAATCGTCCATTGAT
TTCAAAATTAATGGAAATGGGTGTTTCTGTAACAGAAGAAGAATACGGTATTCGCGTTCAAGCAAACACGCCAAAGCTCA
AACCTGTAACGGTTAAAACCTTGCCTCATCCAGGTTTTCCAACAGACATGCAAGCTCAATTTACAGCTTTAATGGCAGTG
GTCAATGGAGAGTCTACTATGGTTGAAACTGTCTTTGAAAATCGATTTCAACATCTGGAAGAAATGCGACGCATGGGCTT
ACAATCTGAAATCCTTAGGGAAACTGCCATGATTCATGGTGGAAGACAACTGCAAGGTGCTCCTGTGATGTCAACAGATT
TACGTGCCAGTGCTGCCCTTATCTTGACAGGGATTGTTGCTCAAGGAGTTACAATAGTTAATAATTTGGTTCATTTAGAT
CGTGGCTACTATCAATTTCATGAAAAATTAGCAAAGCTTGGAGCTACTATTAGTCGTAGCAGTGAGGTCTAG

Upstream 100 bases:

>100_bases
CAAATTAGCCAGACGCTCTTTTTTGAGTTCCGCTAATACTGGAATAAAAGAAGTATGGTATAATTTTACTACGACTAAGA
GATAGATAAGGGAGAAAATT

Downstream 100 bases:

>100_bases
CTTATGACAAATGGTTTAAAATATGTCTTAGAACAAATGTTATTACTTTTCATAATTGCTGCCTTGGCGTGTCTTTTTTT
AGCCATTGGACTTATGATTG

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MDKIIIEGGQTRLEGEVVIEGAKNAVLPLLAASILPSKGKTILRNVPILSDVFTMNNVVRGLDIRVDFNEAANEITVDAS
GHILDEAPYEYVSQMRASIVVLGPILARNGHAKVSMPGGCTIGSRPINLHLKGLEAMGATITQKGGDITAQADRLQGAMI
YMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLAQFLNKMGARIRGAGTETLTITGVTHLRGVEHDVVQDRIEAG
TFMVAAAMTSGNVLIRDAVWEHNRPLISKLMEMGVSVTEEEYGIRVQANTPKLKPVTVKTLPHPGFPTDMQAQFTALMAV
VNGESTMVETVFENRFQHLEEMRRMGLQSEILRETAMIHGGRQLQGAPVMSTDLRASAALILTGIVAQGVTIVNNLVHLD
RGYYQFHEKLAKLGATISRSSEV

Sequences:

>Translated_423_residues
MDKIIIEGGQTRLEGEVVIEGAKNAVLPLLAASILPSKGKTILRNVPILSDVFTMNNVVRGLDIRVDFNEAANEITVDAS
GHILDEAPYEYVSQMRASIVVLGPILARNGHAKVSMPGGCTIGSRPINLHLKGLEAMGATITQKGGDITAQADRLQGAMI
YMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLAQFLNKMGARIRGAGTETLTITGVTHLRGVEHDVVQDRIEAG
TFMVAAAMTSGNVLIRDAVWEHNRPLISKLMEMGVSVTEEEYGIRVQANTPKLKPVTVKTLPHPGFPTDMQAQFTALMAV
VNGESTMVETVFENRFQHLEEMRRMGLQSEILRETAMIHGGRQLQGAPVMSTDLRASAALILTGIVAQGVTIVNNLVHLD
RGYYQFHEKLAKLGATISRSSEV
>Mature_423_residues
MDKIIIEGGQTRLEGEVVIEGAKNAVLPLLAASILPSKGKTILRNVPILSDVFTMNNVVRGLDIRVDFNEAANEITVDAS
GHILDEAPYEYVSQMRASIVVLGPILARNGHAKVSMPGGCTIGSRPINLHLKGLEAMGATITQKGGDITAQADRLQGAMI
YMDFPSVGATQNLMMAATLADGVTTIENAAREPEIVDLAQFLNKMGARIRGAGTETLTITGVTHLRGVEHDVVQDRIEAG
TFMVAAAMTSGNVLIRDAVWEHNRPLISKLMEMGVSVTEEEYGIRVQANTPKLKPVTVKTLPHPGFPTDMQAQFTALMAV
VNGESTMVETVFENRFQHLEEMRRMGLQSEILRETAMIHGGRQLQGAPVMSTDLRASAALILTGIVAQGVTIVNNLVHLD
RGYYQFHEKLAKLGATISRSSEV

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=420, Percent_Identity=49.047619047619, Blast_Score=377, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA1_STRP1 (P65458)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268985.1
- RefSeq:   YP_281947.1
- ProteinModelPortal:   P65458
- SMR:   P65458
- EnsemblBacteria:   EBSTRT00000000430
- EnsemblBacteria:   EBSTRT00000029185
- GeneID:   3572330
- GeneID:   900942
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0763
- KEGG:   spz:M5005_Spy_0584
- GeneTree:   EBGT00050000028044
- HOGENOM:   HBG482701
- OMA:   MVKTMRA
- ProtClustDB:   PRK09369
- BioCyc:   SPYO160490:SPY0763-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0584-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45671; Mature: 45671

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: ACT_SITE 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIIIEGGQTRLEGEVVIEGAKNAVLPLLAASILPSKGKTILRNVPILSDVFTMNNVVR
CCCEEEECCCCEECCEEEEECCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHC
GLDIRVDFNEAANEITVDASGHILDEAPYEYVSQMRASIVVLGPILARNGHAKVSMPGGC
CEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHCEEEEEHHHCCCCCEEEECCCCC
TIGSRPINLHLKGLEAMGATITQKGGDITAQADRLQGAMIYMDFPSVGATQNLMMAATLA
EECCCCEEEEEECHHHHCCEEECCCCCEEEEHHHCCCEEEEEECCCCCCCCHHEEEHHHH
DGVTTIENAAREPEIVDLAQFLNKMGARIRGAGTETLTITGVTHLRGVEHDVVQDRIEAG
CCHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCCEEEEEEHHHHCCCHHHHHHHHHHCC
TFMVAAAMTSGNVLIRDAVWEHNRPLISKLMEMGVSVTEEEYGIRVQANTPKLKPVTVKT
EEEEEEEECCCCEEEEECHHCCCCHHHHHHHHCCCEEECHHCCEEEECCCCCCCEEEEEE
LPHPGFPTDMQAQFTALMAVVNGESTMVETVFENRFQHLEEMRRMGLQSEILRETAMIHG
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GRQLQGAPVMSTDLRASAALILTGIVAQGVTIVNNLVHLDRGYYQFHEKLAKLGATISRS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
SEV
CCC
>Mature Secondary Structure
MDKIIIEGGQTRLEGEVVIEGAKNAVLPLLAASILPSKGKTILRNVPILSDVFTMNNVVR
CCCEEEECCCCEECCEEEEECCCCHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHC
GLDIRVDFNEAANEITVDASGHILDEAPYEYVSQMRASIVVLGPILARNGHAKVSMPGGC
CEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHCEEEEEHHHCCCCCEEEECCCCC
TIGSRPINLHLKGLEAMGATITQKGGDITAQADRLQGAMIYMDFPSVGATQNLMMAATLA
EECCCCEEEEEECHHHHCCEEECCCCCEEEEHHHCCCEEEEEECCCCCCCCHHEEEHHHH
DGVTTIENAAREPEIVDLAQFLNKMGARIRGAGTETLTITGVTHLRGVEHDVVQDRIEAG
CCHHHHHHHCCCCHHHHHHHHHHHHCCEEECCCCCEEEEEEHHHHCCCHHHHHHHHHHCC
TFMVAAAMTSGNVLIRDAVWEHNRPLISKLMEMGVSVTEEEYGIRVQANTPKLKPVTVKT
EEEEEEEECCCCEEEEECHHCCCCHHHHHHHHCCCEEECHHCCEEEECCCCCCCEEEEEE
LPHPGFPTDMQAQFTALMAVVNGESTMVETVFENRFQHLEEMRRMGLQSEILRETAMIHG
CCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GRQLQGAPVMSTDLRASAALILTGIVAQGVTIVNNLVHLDRGYYQFHEKLAKLGATISRS
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCC
SEV
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296