Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is whiA

Identifier: 15674722

GI number: 15674722

Start: 528543

End: 529454

Strand: Direct

Name: whiA

Synonym: SPy_0654

Alternate gene names: 15674722

Gene position: 528543-529454 (Clockwise)

Preceding gene: 15674721

Following gene: 15674726

Centisome position: 28.53

GC content: 39.58

Gene sequence:

>912_bases
ATGAGTTTTACAACCAAGGTCAAAGAGGAATTAATTCACTTGTCCACAGGTGACAACAATGAATTGGCCGCCATTATCAA
ATTATCAGGCAGCTTGGGCTTAGCTCACCAAAGCCTTCATTTATCCATTACCACTGAAAATGCTAAAATTGCCCGCTACA
TTTATTCTCTTATTGAAGACGCCTATGTTATCGTGCCAGAAATCAGGTATCATCAAAAGACGAACCTGCGCAAAAACCGT
GTTTACACCGTCTATGTTGAGCAAGGTGTGGAAACCATTTTAGCCGATTTGAAATTAGCGGACTCCTTTTTTGGTCTGGA
AACAGGCATCGAACCTCAGGTTTTATCAGACGATAATGCTGGCCGTTCTTATCTTAAAGGGGCTTTTCTAGCGGCAGGTA
GCATCAGAGATCCTGAGTCAGGCAAGTATCAGTTAGAAATCTATTCAGTTTATCTTGATCATGCTCAAGATTTAGCTCAA
CTCATGCAAAAATTTATGCTAGATGCCAAAACCATCGAGCATAAAAGCGGTGCAGTTACTTATTTGCAAAAGGCAGAAGA
TATCATGGACTTTTTAATTATAATTGGTGCCATGTCCTGCAAAGAAGACTTTGAAGCCATCAAATTACTTCGAGAAGCTC
GAAATGATATTAACCGTGCCAATAATGCAGAAACAGCTAATATTGCCAAAACTATCAGTGCTAGCATGAAAACCATTAAT
AATATTATTAAAATCATGGACACAATTGGTTTAGAAAGTTTACCGATTGAATTGCAACAGGTAGCCCAGCTTCGGGTTAA
GCATCCAGACTATTCCATTCAACAAGTTGCTGATGCTCTTGAGTTCCCAATCACCAAGAGCGGGGTCAACCATCGCTTGC
GTAAAATCAATAAAATTGCAGATGACTTATAG

Upstream 100 bases:

>100_bases
TGATTTCGTCTTATTTTTTACGGTTGGAGAATGGCGGAGCTTTTCACGATGGTAACTTAGTGGTGGAAGAATTAATGAAT
TTAGTGAGGATAGTCAAGCA

Downstream 100 bases:

>100_bases
AACATTTTTATCGTATGAGCCTTTGTTCATACGATTTTTTTGTCTAAAAGTCGTTTTCCATTGTTTTTTTGAAGTGTCTG
ATGTTCTGTGATATGATAAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSFTTKVKEELIHLSTGDNNELAAIIKLSGSLGLAHQSLHLSITTENAKIARYIYSLIEDAYVIVPEIRYHQKTNLRKNR
VYTVYVEQGVETILADLKLADSFFGLETGIEPQVLSDDNAGRSYLKGAFLAAGSIRDPESGKYQLEIYSVYLDHAQDLAQ
LMQKFMLDAKTIEHKSGAVTYLQKAEDIMDFLIIIGAMSCKEDFEAIKLLREARNDINRANNAETANIAKTISASMKTIN
NIIKIMDTIGLESLPIELQQVAQLRVKHPDYSIQQVADALEFPITKSGVNHRLRKINKIADDL

Sequences:

>Translated_303_residues
MSFTTKVKEELIHLSTGDNNELAAIIKLSGSLGLAHQSLHLSITTENAKIARYIYSLIEDAYVIVPEIRYHQKTNLRKNR
VYTVYVEQGVETILADLKLADSFFGLETGIEPQVLSDDNAGRSYLKGAFLAAGSIRDPESGKYQLEIYSVYLDHAQDLAQ
LMQKFMLDAKTIEHKSGAVTYLQKAEDIMDFLIIIGAMSCKEDFEAIKLLREARNDINRANNAETANIAKTISASMKTIN
NIIKIMDTIGLESLPIELQQVAQLRVKHPDYSIQQVADALEFPITKSGVNHRLRKINKIADDL
>Mature_302_residues
SFTTKVKEELIHLSTGDNNELAAIIKLSGSLGLAHQSLHLSITTENAKIARYIYSLIEDAYVIVPEIRYHQKTNLRKNRV
YTVYVEQGVETILADLKLADSFFGLETGIEPQVLSDDNAGRSYLKGAFLAAGSIRDPESGKYQLEIYSVYLDHAQDLAQL
MQKFMLDAKTIEHKSGAVTYLQKAEDIMDFLIIIGAMSCKEDFEAIKLLREARNDINRANNAETANIAKTISASMKTINN
IIKIMDTIGLESLPIELQQVAQLRVKHPDYSIQQVADALEFPITKSGVNHRLRKINKIADDL

Specific function: May be required for sporulation

COG id: COG1481

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the whiA transcriptional regulatory family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): WHIA_STRP1 (Q9A0R6)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268896.1
- RefSeq:   YP_281904.1
- ProteinModelPortal:   Q9A0R6
- EnsemblBacteria:   EBSTRT00000000568
- EnsemblBacteria:   EBSTRT00000028195
- GeneID:   3572363
- GeneID:   900849
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0654
- KEGG:   spz:M5005_Spy_0541
- GeneTree:   EBGT00050000028037
- HOGENOM:   HBG485718
- OMA:   DSFFGIE
- ProtClustDB:   CLSK877081
- BioCyc:   SPYO160490:SPY0654-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0541-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_01420
- InterPro:   IPR003802
- InterPro:   IPR023054
- InterPro:   IPR018478
- TIGRFAMs:   TIGR00647

Pfam domain/function: PF02650 HTH_WhiA; PF10298 WhiA_N

EC number: NA

Molecular weight: Translated: 33915; Mature: 33784

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTTKVKEELIHLSTGDNNELAAIIKLSGSLGLAHQSLHLSITTENAKIARYIYSLIED
CCCHHHHHHHHEECCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHC
AYVIVPEIRYHQKTNLRKNRVYTVYVEQGVETILADLKLADSFFGLETGIEPQVLSDDNA
CEEEECCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
GRSYLKGAFLAAGSIRDPESGKYQLEIYSVYLDHAQDLAQLMQKFMLDAKTIEHKSGAVT
CHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
YLQKAEDIMDFLIIIGAMSCKEDFEAIKLLREARNDINRANNAETANIAKTISASMKTIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
NIIKIMDTIGLESLPIELQQVAQLRVKHPDYSIQQVADALEFPITKSGVNHRLRKINKIA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DDL
CCC
>Mature Secondary Structure 
SFTTKVKEELIHLSTGDNNELAAIIKLSGSLGLAHQSLHLSITTENAKIARYIYSLIED
CCHHHHHHHHEECCCCCCCCEEEEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHHHC
AYVIVPEIRYHQKTNLRKNRVYTVYVEQGVETILADLKLADSFFGLETGIEPQVLSDDNA
CEEEECCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCC
GRSYLKGAFLAAGSIRDPESGKYQLEIYSVYLDHAQDLAQLMQKFMLDAKTIEHKSGAVT
CHHHHHHHHHCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
YLQKAEDIMDFLIIIGAMSCKEDFEAIKLLREARNDINRANNAETANIAKTISASMKTIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
NIIKIMDTIGLESLPIELQQVAQLRVKHPDYSIQQVADALEFPITKSGVNHRLRKINKIA
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
DDL
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296