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The map label for this gene is msrA.2

Identifier: 15674584

GI number: 15674584

Start: 382192

End: 382701

Strand: Direct

Name: msrA.2

Synonym: SPy_0466

Alternate gene names: 15674584

Gene position: 382192-382701 (Clockwise)

Preceding gene: 15674583

Following gene: 15674585

Centisome position: 20.63

GC content: 42.55

Gene sequence:

>510_bases
ATGGAAAGAGCCATTTTTGCAGGAGGTTGTTTCTGGTGTATGGTGCAACCTTTTGAGGAGCAAGCAGGTATTTTGTCAGT
CAGAAGTGGCTACACAGGTGGGCATCTCCCAAATCCTAGCTATGAACAAGTTTGTGCCAAAACAACAGGACATACAGAAG
CTGTTGAAATTATTTTTGACCCTAAGCAAATCGCTTATAAAGATTTGGTAGAGCTCTATTGGACGCAGACGGATCCAACA
GACGCCTTTGGGCAATTTGAAGATCGTGGGGACAACTACCGTCCTGTCATTTACTACACAACGGAAAGACAAAAAGAAAT
TGCAGAGCAATCAAAAGCAAACTTGCAAGCTTCAGGACGTTTTGACCAACCCATTGTCACCACTATTGAACCAGCAGAGC
CATTTTATCTCGCAGAGGATTATCACCAAGGATTTTATAAAAAGAATCCCAAGCGGTATGCACAAAGCAGTGCTATTCGT
CATCAGTTTTTAGAGGAGAATTGGTCATGA

Upstream 100 bases:

>100_bases
CGCCACAGGAACTGAATTAATAGGATAAAAATGCTTTGCCACTGGCAAAGTTTTTTGTTACAATGAAGACCATTAAGTGA
AGAAAAAGGGGATATAGAGA

Downstream 100 bases:

>100_bases
GAAAATCATTTTACAGCTGGCTGATGACACAACGTAACCCTAAATCAAATGAACCTGTGGCGATTTTAGCAGATTTGGTG
TTTGATGACACCACTTTTCC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPKQIAYKDLVELYWTQTDPT
DAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIR
HQFLEENWS

Sequences:

>Translated_169_residues
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPKQIAYKDLVELYWTQTDPT
DAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIR
HQFLEENWS
>Mature_169_residues
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFDPKQIAYKDLVELYWTQTDPT
DAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGRFDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIR
HQFLEENWS

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=38.7096774193548, Blast_Score=126, Evalue=8e-30,
Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=38.7096774193548, Blast_Score=126, Evalue=9e-30,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=40.1869158878505, Blast_Score=87, Evalue=7e-18,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=44.4444444444444, Blast_Score=133, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=36.4238410596026, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=29.2993630573248, Blast_Score=79, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=32.7272727272727, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45553131, Length=160, Percent_Identity=32.5, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=32.1212121212121, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_STRP1 (Q9A149)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268758.1
- RefSeq:   YP_281745.1
- ProteinModelPortal:   Q9A149
- SMR:   Q9A149
- EnsemblBacteria:   EBSTRT00000001557
- EnsemblBacteria:   EBSTRT00000028569
- GeneID:   3572515
- GeneID:   900707
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0466
- KEGG:   spz:M5005_Spy_0382
- GeneTree:   EBGT00050000027538
- HOGENOM:   HBG748152
- OMA:   SIFPYEK
- ProtClustDB:   PRK14054
- BioCyc:   SPYO160490:SPY0466-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0382-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 19482; Mature: 19482

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: ACT_SITE 10-10

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFD
CCCEEECCCEEEEEECCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEC
PKQIAYKDLVELYWTQTDPTDAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGR
CHHHHHHHHHHHHHCCCCCCCHHCCHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEECCC
FDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS
CCCCEEEEECCCCCEEEHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MERAIFAGGCFWCMVQPFEEQAGILSVRSGYTGGHLPNPSYEQVCAKTTGHTEAVEIIFD
CCCEEECCCEEEEEECCHHCCCCEEEEECCCCCCCCCCCCHHHHHHHCCCCCEEEEEEEC
PKQIAYKDLVELYWTQTDPTDAFGQFEDRGDNYRPVIYYTTERQKEIAEQSKANLQASGR
CHHHHHHHHHHHHHCCCCCCCHHCCHHCCCCCCCCEEEEECCHHHHHHHHHHCCCEECCC
FDQPIVTTIEPAEPFYLAEDYHQGFYKKNPKRYAQSSAIRHQFLEENWS
CCCCEEEEECCCCCEEEHHHHHCCHHCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296