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The map label for this gene is fabG [H]

Identifier: 15674564

GI number: 15674564

Start: 363582

End: 364280

Strand: Direct

Name: fabG [H]

Synonym: SPy_0440

Alternate gene names: 15674564

Gene position: 363582-364280 (Clockwise)

Preceding gene: 15674563

Following gene: 15674565

Centisome position: 19.63

GC content: 43.92

Gene sequence:

>699_bases
ATGACTAAAGTTGTTTTAGTGACGGGCTGTGCTAGTGGGATTGGTTATGCACAGGCCCGCTATTTTTTGAAACAAGGGCA
TCACGTATATGGTGTGGATAAGTCGGATAAACCGGACTTAAGCGGTAACTTTCACTTTATCAAATTGGATTTATCCTCTG
AGTTAGCCCCACTATTTAAAGTGGTCCCCAGTGTTGATATTTTGTGTAATACTGCAGGGATTTTAGATGCCTACAAGCCA
CTTTTAGACGTCAGTGATGAAGAAGTGGAACACCTATTTGATATTAATTTTTTTGCGACGGTGAAGTTAACACGTCATTA
TCTTAGACGTATGGTGGAAAAGCAGTCAGGTGTTATCATCAATATGTGCTCAATAGCAAGTTTTATAGCGGGTGGCGGTG
GTGTTGCCTATACGAGTTCTAAGCATGCCCTTGCGGGATTCACGCGCCAGCTGGCTTTGGATTACGCCAAAGATCAGATT
CACATTTTTGGTATAGCACCAGGTGCTGTCAAAACCGCTATGACGGCTAACGATTTTGAGCCTGGTGGCTTAGCAGACTG
GGTAGCTCGTGAGACGCCAATTGGGCGTTGGACTAAACCAGATGAAGTTGCTGAATTAACGGGATTTCTTGCTTCAGGAA
AAGCGAGATCAATGCAAGGCGAGATTGTCAAAATTGACGGTGGCTGGACTTTGAAATGA

Upstream 100 bases:

>100_bases
ACGCCTTATTTTCTGATTCATGTTACTGGTGCAGGTGAAGGTTTTTCCATGTGGGCACCGACACCATGTGATGTGTTAGC
AGAGGATTGGATTGAGGTCA

Downstream 100 bases:

>100_bases
TCACATGCCTTAGCTTGAGCTGGCGCAGTAAGCCCTAGAGGTGTGATGAGTCAAACAGTCAAAGGAGATGAACAAATGAA
ATTAGCGGTTTTGGGGACAG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFKVVPSVDILCNTAGILDAYKP
LLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQI
HIFGIAPGAVKTAMTANDFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK

Sequences:

>Translated_232_residues
MTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFKVVPSVDILCNTAGILDAYKP
LLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQI
HIFGIAPGAVKTAMTANDFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK
>Mature_231_residues
TKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFKVVPSVDILCNTAGILDAYKPL
LDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIH
IFGIAPGAVKTAMTANDFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=28.9256198347107, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=28.3950617283951, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI66933014, Length=176, Percent_Identity=29.5454545454545, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=28.0632411067194, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7705925, Length=236, Percent_Identity=26.271186440678, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI15277342, Length=254, Percent_Identity=26.3779527559055, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=27.9352226720648, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=31.6, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=29.7959183673469, Blast_Score=103, Evalue=6e-24,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=28.2157676348548, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=30.9917355371901, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=27.4590163934426, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=27.4193548387097, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787820, Length=191, Percent_Identity=31.9371727748691, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1786701, Length=187, Percent_Identity=32.0855614973262, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=28.1632653061224, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=26.8595041322314, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789378, Length=243, Percent_Identity=26.7489711934156, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI2367365, Length=235, Percent_Identity=29.7872340425532, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787905, Length=241, Percent_Identity=29.045643153527, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=29.6747967479675, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=31.0756972111554, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=30.6772908366534, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=242, Percent_Identity=26.8595041322314, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=25.8196721311475, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=27.6859504132231, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=26.9709543568465, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=30.0751879699248, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=27.0992366412214, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=257, Percent_Identity=26.0700389105058, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.5019157088123, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=26.7175572519084, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=190, Percent_Identity=28.9473684210526, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322226, Length=216, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=167, Percent_Identity=31.1377245508982, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=29.5081967213115, Blast_Score=104, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24643142, Length=239, Percent_Identity=30.9623430962343, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI23397609, Length=242, Percent_Identity=30.1652892561983, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=30.1960784313725, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355319, Length=245, Percent_Identity=26.9387755102041, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358495, Length=225, Percent_Identity=27.1111111111111, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=26.8, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281364892, Length=195, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 25183; Mature: 25052

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFK
CCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHH
VVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVII
HHCCHHEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCEEE
NMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAPGAVKTAMTANDFE
EHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCCCC
PGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK
CCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECC
>Mature Secondary Structure 
TKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFK
CEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCHHHHHHH
VVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVII
HHCCHHEEECCHHHHHHHHHHHCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHCCEEE
NMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAPGAVKTAMTANDFE
EHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCCCCC
PGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK
CCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]