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The map label for this gene is upp [H]

Identifier: 15674535

GI number: 15674535

Start: 333950

End: 334579

Strand: Direct

Name: upp [H]

Synonym: SPy_0392

Alternate gene names: 15674535

Gene position: 333950-334579 (Clockwise)

Preceding gene: 15674534

Following gene: 15674536

Centisome position: 18.03

GC content: 41.11

Gene sequence:

>630_bases
ATGGGAAAATGTCAAGTTATTTCGCATCCGCTTATCCAACACAAACTTTCAATCTTACGTCGTCAAACCACATCAACTAA
AGATTTTCGTGAGTTGGTTAATGAAATTGCGATGCTGATGGGATATGAAGTGTCACGCGACCTTCCCTTAGAAGATGTCG
ACATCCAAACGCCAGTCTCAAAAACGGTCCAAAAACAGTTAGCTGGTAAAAAATTAGCTATTGTTCCGATTCTTCGTGCT
GGTATTGGGATGGTTGATGGCTTGTTAAGTTTGGTACCAGCTGCAAAAGTTGGCCATATCGGCATGTACCGTAATGAAGA
AACCCTTGAACCTGTTGAATACCTCGTTAAACTACCAGAAGATATTAACCAACGACAAATTTTCCTTGTTGATCCAATGT
TGGCAACAGGTGGCTCGGCTATCTTAGCAGTGGATTCGTTGAAAAAACGTGGCGCAGCAAATATTAAGTTTGTCTGTTTA
GTTGCAGCACCAGAAGGGGTGAAAAAACTTCAAGAAGCTCATCCAGATATTGATATCTTCACAGCAGCACTTGATGATCA
TTTAAATGAACATGGCTATATCGTGCCAGGATTGGGCGATGCTGGTGATCGTTTATTTGGGACAAAATAA

Upstream 100 bases:

>100_bases
AGTAAAGGTAGCTGATAAAAAATCAGGATTTCCCAAGCAAACTACTGATATTTTTGGTATAATGATAAAAGTGTAAAAAA
ATAGAAGGAAGTATATCAAC

Downstream 100 bases:

>100_bases
AAGAGACAACCATCAAATAGTAGCCTTTTTAGGCCAATCGTTCTTGATTTTGTTTAAAAAATCAGAGAGATTTCTCTTCT
TTAAAGGAAAAGCAAGTTTA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPLEDVDIQTPVSKTVQKQLAGKKLAIVPILRA
GIGMVDGLLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCL
VAAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPLEDVDIQTPVSKTVQKQLAGKKLAIVPILRA
GIGMVDGLLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCL
VAAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGDAGDRLFGTK
>Mature_208_residues
GKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPLEDVDIQTPVSKTVQKQLAGKKLAIVPILRAG
IGMVDGLLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPEDINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCLV
AAPEGVKKLQEAHPDIDIFTAALDDHLNEHGYIVPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=204, Percent_Identity=32.3529411764706, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI57863312, Length=204, Percent_Identity=32.3529411764706, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI21450816, Length=194, Percent_Identity=28.3505154639175, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=55.1724137931034, Blast_Score=243, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=40.1041666666667, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45550449, Length=204, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573516, Length=204, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573514, Length=204, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573512, Length=204, Percent_Identity=31.3725490196078, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358379, Length=195, Percent_Identity=26.1538461538462, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22826; Mature: 22695

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPLEDVDIQTPVS
CCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
KTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPE
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHCCC
DINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCLVAAPEGVKKLQEAHPDIDIF
CCCCCEEEEECCHHHCCCCEEEEHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCHHHH
TAALDDHLNEHGYIVPGLGDAGDRLFGTK
HHHHHHHCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
GKCQVISHPLIQHKLSILRRQTTSTKDFRELVNEIAMLMGYEVSRDLPLEDVDIQTPVS
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
KTVQKQLAGKKLAIVPILRAGIGMVDGLLSLVPAAKVGHIGMYRNEETLEPVEYLVKLPE
HHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHCCC
DINQRQIFLVDPMLATGGSAILAVDSLKKRGAANIKFVCLVAAPEGVKKLQEAHPDIDIF
CCCCCEEEEECCHHHCCCCEEEEHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCHHHH
TAALDDHLNEHGYIVPGLGDAGDRLFGTK
HHHHHHHCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA