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The map label for this gene is murC

Identifier: 15674501

GI number: 15674501

Start: 302363

End: 303691

Strand: Direct

Name: murC

Synonym: SPy_0345

Alternate gene names: 15674501

Gene position: 302363-303691 (Clockwise)

Preceding gene: 15674500

Following gene: 15674502

Centisome position: 16.32

GC content: 37.4

Gene sequence:

>1329_bases
ATGTCAAAAACGTATCATTTTATCGGAATTAAAGGGTCAGGAATGAGTGCCTTGGCCCTTATGTTGCATCAAATGGGGCA
TAAGGTGCAAGGTAGTGATGTTGAAAAATACTATTTCACTCAAAGAGGATTGGAACAAGCGGGCATCACTATCTTACCTT
TTAGCGAGGACAACATTACGCCAGATATGGAACTTATCGTTGGGAATGCCTTTCGTGAAAACAACAAAGAAGTGGCCTAT
GCTTTGAGACACCAGATTCCTTTCAAACGTTATCATGACTTTTTAGGTGATTTTATGAAATCATTTATCAGTTTTGCAGT
AGCAGGTGCTCATGGTAAAACTTCTACAACGGGTTTATTGTCACATGTCTTGAAAAATATCACAGACACATCTTATTTAA
TTGGTGATGGTACTGGGCGTGGATCTGCTAATGCACAGTATTTTGTTTTTGAATCAGACGAATACGAACGCCATTTTATG
CCTTATCACCCAGAATACTCTATCATTACTAATATTGATTTTGACCATCCTGATTATTTCACAGGAATTGCTGATGTGCG
AAACGCTTTCAACGATTATGCTAAGCAGGTCAAGAAAGCTTTGTTTGTTTATGGTGAAGATGACGAACTAAAAAAGATCG
AAGCACCTGCACCTATTTACTATTATGGTTTTGAAGAGGGCAATGATTTTATCGCTTACGACATTACGCGTACTACGAAC
GGATCGGACTTTAAGGTAAAACACCAAGGAGAGGTCATTGGTCAGTTTCACGTACCTGCTTATGGAAAACATAACATTTT
AAACGCTACAGCAGTAATTGCAAACTTGTTTGTAGCCGGCATTGATATGGCTCTAGTGGCAGACCATCTTAAAACTTTTT
CAGGTGTGAAACGTCGTTTTACAGAGAAAATTATCAATGACACTATTATTATTGATGACTTTGCTCATCATCCAACCGAA
ATTGTGGCAACAATTGATGCGGCTAGACAAAAATACCCAAGTAAAGAAATTGTAGCAATATTCCAGCCACATACTTTTAC
TCGCACTATTGCCTTATTAGAGGATTTTGCTTGTGCTTTAAATGAAGCTGACAGTGTTTATTTAGCCCAGATTTATGGTT
CTGCACGTGAAGTAGATAAAGGTGAAGTTAAGGTTGAAGATTTGGCTGCTAAGATTATCAAACCATCACAAGTAGTAACG
GTGGAAAATGTCTCTCCTCTTCTTGATCACGATAATGCTGTTTATGTTTTTATGGGAGCTGGAGATATTCAGCTATATGA
ACATTCTTTTGAGGAATTACTTGCAAATTTAACTAAAAATAACCAATAA

Upstream 100 bases:

>100_bases
ACAACGAGAAAAAACAATTGCGCAAGAGCTTAATCTTAGTAGGTTTGAGGATCTTCCTTAATAAATCTACTCAGCGTATG
CAGATGACAAAGGAGTTAAG

Downstream 100 bases:

>100_bases
CATGTCCTGCCTTAGGCAGGTTTTCTCATTCTAAAGGAGTTTGATATGTTGATTAGACAGGTTCAAGGATCCGATTTGGA
AGTTATTGCTACCATTGAAA

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAY
ALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFM
PYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTE
IVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVT
VENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ

Sequences:

>Translated_442_residues
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAY
ALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFM
PYHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTE
IVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVT
VENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ
>Mature_441_residues
SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNITPDMELIVGNAFRENNKEVAYA
LRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLLSHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMP
YHPEYSIITNIDFDHPDYFTGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTNG
SDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRFTEKIINDTIIIDDFAHHPTEI
VATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACALNEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVTV
ENVSPLLDHDNAVYVFMGAGDIQLYEHSFEELLANLTKNNQ

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1790680, Length=425, Percent_Identity=30.3529411764706, Blast_Score=165, Evalue=7e-42,
Organism=Escherichia coli, GI1786279, Length=459, Percent_Identity=27.6688453159041, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_STRP1 (Q9A1C7)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268675.1
- RefSeq:   YP_281654.1
- ProteinModelPortal:   Q9A1C7
- SMR:   Q9A1C7
- EnsemblBacteria:   EBSTRT00000001130
- EnsemblBacteria:   EBSTRT00000028592
- GeneID:   3572619
- GeneID:   900623
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0345
- KEGG:   spz:M5005_Spy_0290
- GeneTree:   EBGT00050000027198
- HOGENOM:   HBG476594
- OMA:   TEMRATI
- ProtClustDB:   PRK00421
- BioCyc:   SPYO160490:SPY0345-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0290-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49594; Mature: 49463

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNIT
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCEEEEECCCCCCC
PDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLL
CCHHEEEECHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
SHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYF
HHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHH
TGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
HHHHHHHHHHHHHHHHHHHHEEEECCCCCHHEECCCCCEEEEEECCCCEEEEEEEEECCC
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRF
CCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACAL
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
NEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGA
CCCCCEEEEEECCCHHCCCCCCEEHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEEECC
GDIQLYEHSFEELLANLTKNNQ
CCEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKTYHFIGIKGSGMSALALMLHQMGHKVQGSDVEKYYFTQRGLEQAGITILPFSEDNIT
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHCCEEEEECCCCCCC
PDMELIVGNAFRENNKEVAYALRHQIPFKRYHDFLGDFMKSFISFAVAGAHGKTSTTGLL
CCHHEEEECHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHH
SHVLKNITDTSYLIGDGTGRGSANAQYFVFESDEYERHFMPYHPEYSIITNIDFDHPDYF
HHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCHHH
TGIADVRNAFNDYAKQVKKALFVYGEDDELKKIEAPAPIYYYGFEEGNDFIAYDITRTTN
HHHHHHHHHHHHHHHHHHHHEEEECCCCCHHEECCCCCEEEEEECCCCEEEEEEEEECCC
GSDFKVKHQGEVIGQFHVPAYGKHNILNATAVIANLFVAGIDMALVADHLKTFSGVKRRF
CCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEKIINDTIIIDDFAHHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIALLEDFACAL
HHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHH
NEADSVYLAQIYGSAREVDKGEVKVEDLAAKIIKPSQVVTVENVSPLLDHDNAVYVFMGA
CCCCCEEEEEECCCHHCCCCCCEEHHHHHHHHCCCCEEEEECCCCHHHCCCCEEEEEECC
GDIQLYEHSFEELLANLTKNNQ
CCEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296