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The map label for this gene is htpX

Identifier: 15674492

GI number: 15674492

Start: 289905

End: 290801

Strand: Direct

Name: htpX

Synonym: SPy_0331

Alternate gene names: 15674492

Gene position: 289905-290801 (Clockwise)

Preceding gene: 15674491

Following gene: 15674493

Centisome position: 15.65

GC content: 40.58

Gene sequence:

>897_bases
ATGCTTTATCAACAGATTTCACAAAATAAGCAACGAACAGTTGTTTTATTAGTTGGTTTCTTCGCTCTCTTAGCACTTAT
TGGAGCTTCAGCAGGCTATCTGCTGTTAGATAATTATGCCATGGGCTTGGTCCTTGCTCTTGTCATTGGGGTGATTTATG
CTACCAGTATGATTTTTCAATCCACCAGTCTTGTAATGAGTATGAACAATGCTAGAGAAGTTACAGAAAAAGAGGCTCCA
GGCTTTTTCCATATTGTCGAGGATATGGCTATGGTGGCCCAGATTCCGATGCCGAGAGTTTTTATTATTGAAGATCCTTC
TTTAAATGCTTTTGCGACAGGATCTAGCCCTCAAAATGCTGCTGTTGCAGCAACGACAGGTTTACTTGAAGTCATGAATC
GTGAAGAACTTGAAGGTGTTATCGGCCATGAAATTAGCCACATCCGAAATTATGATATCCGTATTTCGACTATTGCTGTA
GCTTTGGCGAGTGCTGTTACCGTTATTTCTAGTATCGGTGGGCGTATGCTATGGTATGGTGGCGGTTCTCGCAGGCAAAG
AGATGACGGAGATGATGATGTTTTAAGAATCATTACATTACTTTTGTCGTTATTATCTTTGCTTTTAGCGCCCCTAGTAG
CAAGTTTGATTCAGTTGGCTATTTCTCGTCAAAGAGAATATCTAGCTGATGCTAGTTCTGTTGAACTAACAAGAAATCCC
CAAGGTATGATTAAGGCTCTTGAAAAATTGCAGTTATCTCAGCCAATGAAGCATCCTGTTGATGATGCTAGTGCGGCCTT
GTATATTAATGAGCCTCGCAAAAAAAGGAGCTTCAGTTCATTATTCAGCACCCATCCTCCTATTGAGGAGAGGATTGAAA
GGTTAAAAAACATGTGA

Upstream 100 bases:

>100_bases
TTACAAACACCAGAAGCTGAAAAAGAAGTTCCAAAAGTTGAATTTAACTTTTAAATATGAAATTATCATCTAGTAGGCAA
TCATAAGAGAAAGGAGAATT

Downstream 100 bases:

>100_bases
GCGTTTGGGGTTTTTGCTCAAGCCTCACTTTTTTATGTCTTTGGGCAGATAATCTAAAATGGCAGGAATTATCAAAAATA
TCTGAACAAAAAGAAAAAAA

Product: heat shock protein HtpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MLYQQISQNKQRTVVLLVGFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQSTSLVMSMNNAREVTEKEAP
GFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAV
ALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM

Sequences:

>Translated_298_residues
MLYQQISQNKQRTVVLLVGFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQSTSLVMSMNNAREVTEKEAP
GFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAV
ALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM
>Mature_298_residues
MLYQQISQNKQRTVVLLVGFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQSTSLVMSMNNAREVTEKEAP
GFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNAAVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAV
ALASAVTVISSIGGRMLWYGGGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family

Homologues:

Organism=Escherichia coli, GI1788133, Length=217, Percent_Identity=38.2488479262673, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HTPX_STRP1 (Q9A1D5)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268666.1
- RefSeq:   YP_281644.1
- ProteinModelPortal:   Q9A1D5
- SMR:   Q9A1D5
- EnsemblBacteria:   EBSTRT00000001060
- EnsemblBacteria:   EBSTRT00000027526
- GeneID:   3572648
- GeneID:   900614
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0331
- KEGG:   spz:M5005_Spy_0280
- GeneTree:   EBGT00050000027537
- HOGENOM:   HBG739460
- OMA:   RRGAEIC
- ProtClustDB:   PRK04897
- BioCyc:   SPYO160490:SPY0331-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0280-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00188
- InterPro:   IPR022919
- InterPro:   IPR001915

Pfam domain/function: PF01435 Peptidase_M48

EC number: 3.4.24.-

Molecular weight: Translated: 32716; Mature: 32716

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 144-144

Signals:

None

Transmembrane regions:

HASH(0xb96754c)-; HASH(0xca37248)-; HASH(0xb2c9d54)-; HASH(0xb2cab70)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYQQISQNKQRTVVLLVGFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQ
CCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
STSLVMSMNNAREVTEKEAPGFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNA
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCC
AVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAVALASAVTVISSIGGRMLWYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
GGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCH
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCH
>Mature Secondary Structure
MLYQQISQNKQRTVVLLVGFFALLALIGASAGYLLLDNYAMGLVLALVIGVIYATSMIFQ
CCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
STSLVMSMNNAREVTEKEAPGFFHIVEDMAMVAQIPMPRVFIIEDPSLNAFATGSSPQNA
HHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCCCCCC
AVAATTGLLEVMNREELEGVIGHEISHIRNYDIRISTIAVALASAVTVISSIGGRMLWYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEC
GGSRRQRDDGDDDVLRIITLLLSLLSLLLAPLVASLIQLAISRQREYLADASSVELTRNP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCH
QGMIKALEKLQLSQPMKHPVDDASAALYINEPRKKRSFSSLFSTHPPIEERIERLKNM
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11296296