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The map label for this gene is plr [H]

Identifier: 15674453

GI number: 15674453

Start: 239580

End: 240590

Strand: Direct

Name: plr [H]

Synonym: SPy_0274

Alternate gene names: 15674453

Gene position: 239580-240590 (Clockwise)

Preceding gene: 15674452

Following gene: 15674456

Centisome position: 12.93

GC content: 41.44

Gene sequence:

>1011_bases
ATGGTAGTTAAAGTTGGTATTAACGGTTTCGGTCGTATCGGACGTCTTGCATTCCGCCGTATTCAAAACATCGAAGGTGT
TGAAGTAACTCGTATCAATGACCTTACAGATCCAAATATGCTTGCACACTTGTTGAAATACGATACAACTCAAGGTCGTT
TTGATGGAACAGTTGAAGTTAAAGAAGGTGGATTTGAAGTAAACGGAAACTTCATCAAAGTTTCTGCTGAACGTGATCCA
GAAAACATCGACTGGGCAACTGATGGGGTTGAAATCGTTCTTGAAGCAACTGGTTTCTTTGCTAAAAAAGAAGCAGCTGA
AAAACACTTACATGCTAACGGTGCTAAAAAAGTTGTTATCACAGCTCCTGGTGGAAACGATGTTAAAACAGTTGTTTTCA
ACACTAACCACGACATTCTTGACGGTACTGAAACAGTTATCTCAGGTGCTTCATGTACTACAAACTGTTTAGCTCCTATG
GCTAAAGCTCTTCACGATGCATTCGGTATTCAAAAAGGTCTTATGACTACAATCCACGCTTACACTGGTGACCAAATGAT
CCTTGACGGACCACACCGTGGTGGTGACCTTCGTCGTGCACGCGCTGGTGCTGCAAATATCGTTCCTAACTCAACTGGTG
CTGCTAAAGCTATCGGTCTTGTTATCCCAGAACTTAACGGTAAACTTGACGGTGCTGCACAACGTGTTCCTGTTCCAACT
GGATCAGTAACTGAGTTGGTTGTAACTCTTGACAAAAACGTTTCTGTTGACGAAATCAACGCTGCTATGAAAGCTGCTTC
AAACGATAGCTTCGGTTACACTGAAGATCCAATCGTTTCTTCAGATATCGTAGGCGTATCATACGGTTCATTGTTTGACG
CAACTCAAACTAAAGTAATGGAAGTTGACGGATCACAATTGGTTAAAGTTGTATCATGGTATGACAACGAAATGTCTTAC
ACTGCTCAACTTGTACGTACTCTTGAGTACTTCGCAAAAATTGCTAAATAA

Upstream 100 bases:

>100_bases
AAGGTTGTTACAGATGACTGTAAGTTAATCTTTTCACAATAGGTAGGGAGCATTCCCTCTAAATAATATTCTTTTGATTT
TCATAAGGAGGAAATCACTA

Downstream 100 bases:

>100_bases
TTAGTTATAACGAAAGAGAGCTTGGTTTATGCTGAGTTCTTTTTCGTATACTTTAAACACTACCTTAAATGTATGATTTT
AACGTTTTGAACTATTCTAG

Product: glyceraldehyde-3-phosphate dehydrogenase

Products: NA

Alternate protein names: GAPDH; Plasmin receptor; Plasminogen-binding protein [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGNFIKVSAERDP
ENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPM
AKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
GSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVVSWYDNEMSY
TAQLVRTLEYFAKIAK

Sequences:

>Translated_336_residues
MVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGNFIKVSAERDP
ENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPM
AKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
GSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVVSWYDNEMSY
TAQLVRTLEYFAKIAK
>Mature_336_residues
MVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEVKEGGFEVNGNFIKVSAERDP
ENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVITAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPM
AKALHDAFGIQKGLMTTIHAYTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
GSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVMEVDGSQLVKVVSWYDNEMSY
TAQLVRTLEYFAKIAK

Specific function: Also binds human plasminogen [H]

COG id: COG0057

COG function: function code G; Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyceraldehyde-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7669492, Length=335, Percent_Identity=46.2686567164179, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI7657116, Length=332, Percent_Identity=43.3734939759036, Blast_Score=266, Evalue=2e-71,
Organism=Escherichia coli, GI1788079, Length=338, Percent_Identity=50.2958579881657, Blast_Score=319, Evalue=1e-88,
Organism=Escherichia coli, GI1789295, Length=343, Percent_Identity=38.7755102040816, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17568413, Length=340, Percent_Identity=45.5882352941176, Blast_Score=266, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI32566163, Length=340, Percent_Identity=45.5882352941176, Blast_Score=266, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17534677, Length=340, Percent_Identity=45.5882352941176, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17534679, Length=340, Percent_Identity=45.5882352941176, Blast_Score=264, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6322409, Length=338, Percent_Identity=44.3786982248521, Blast_Score=283, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6321631, Length=338, Percent_Identity=45.5621301775148, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6322468, Length=338, Percent_Identity=45.5621301775148, Blast_Score=277, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17933600, Length=333, Percent_Identity=46.5465465465465, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI18110149, Length=333, Percent_Identity=46.5465465465465, Blast_Score=279, Evalue=2e-75,
Organism=Drosophila melanogaster, GI85725000, Length=332, Percent_Identity=46.3855421686747, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI22023983, Length=332, Percent_Identity=46.3855421686747, Blast_Score=275, Evalue=3e-74,
Organism=Drosophila melanogaster, GI19922412, Length=331, Percent_Identity=44.7129909365559, Blast_Score=268, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020831
- InterPro:   IPR020830
- InterPro:   IPR020829
- InterPro:   IPR020828
- InterPro:   IPR006424
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02800 Gp_dh_C; PF00044 Gp_dh_N [H]

EC number: =1.2.1.12 [H]

Molecular weight: Translated: 35943; Mature: 35943

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS00071 GAPDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEE
KEGGFEVNGNFIKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVI
ECCCEEECCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
TAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPMAKALHDAFGIQKGLMTTIHA
ECCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
YTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
ECCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCC
GSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVM
CCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCHHCCCCCEEE
EVDGSQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
EECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVVKVGINGFGRIGRLAFRRIQNIEGVEVTRINDLTDPNMLAHLLKYDTTQGRFDGTVEV
CEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEE
KEGGFEVNGNFIKVSAERDPENIDWATDGVEIVLEATGFFAKKEAAEKHLHANGAKKVVI
ECCCEEECCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEEEE
TAPGGNDVKTVVFNTNHDILDGTETVISGASCTTNCLAPMAKALHDAFGIQKGLMTTIHA
ECCCCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEE
YTGDQMILDGPHRGGDLRRARAGAANIVPNSTGAAKAIGLVIPELNGKLDGAAQRVPVPT
ECCCEEEEECCCCCCCHHHHHCCCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCCCCCC
GSVTELVVTLDKNVSVDEINAAMKAASNDSFGYTEDPIVSSDIVGVSYGSLFDATQTKVM
CCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCHHCCCCCEEE
EVDGSQLVKVVSWYDNEMSYTAQLVRTLEYFAKIAK
EECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8706717 [H]