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The map label for this gene is speG

Identifier: 15674408

GI number: 15674408

Start: 190526

End: 191230

Strand: Direct

Name: speG

Synonym: SPy_0212

Alternate gene names: 15674408

Gene position: 190526-191230 (Clockwise)

Preceding gene: 15674406

Following gene: 15674409

Centisome position: 10.29

GC content: 27.94

Gene sequence:

>705_bases
ATGAAAACAAACATTTTGACAATTATCATATTATCATGTGTTTTTAGCTATGGAAGTCAATTAGCTTATGCAGATGAAAA
TTTAAAAGATTTAAAAAGAAGTTTAAGATTTGCCTATAATATTACCCCATGCGATTATGAAAATGTAGAAATTGCATTTG
TTACTACAAATAGCATACATATTAATACTAAACAAAAAAGATCGGAATGTATTCTTTATGTTGATTCTATTGTATCTTTA
GGCATTACTGATCAGTTTATAAAAGGGGATAAGGTCGATGTTTTTGGTCTCCCTTATAATTTTTCCCCACCTTATGTAGA
TAATATTTATGGTGGTATTGTAAAACATTCGAATCAAGGAAATAAATCATTACAGTTTGTAGGAATTTTAAATCAAGATG
GGAAAGAAACTTATTTGCCCTCTGAGGCTGTTCGCATAAAAAAGAAACAGTTTACTTTACAGGAATTTGATTTTAAAATA
AGAAAATTTCTAATGGAAAAATACAATATCTATGATTCGGAATCGCGTTATACATCGGGGAGCCTTTTCCTTGCTACTAA
AGATAGTAAACATTATGAAGTTGATTTATTTAATAAGGATGATAAGCTTTTAAGTCGAGACAGTTTCTTTAAAAGGTATA
AAGATAATAAGATTTTTAATAGTGAAGAAATTAGTCATTTTGATATCTACTTAAAAACGCACTAG

Upstream 100 bases:

>100_bases
CTAAAGTAATTTCCTCCTTCTATAGTGTCATCAGTTGTTGAAACCGATTGATATTTTTATTTAGGCTAAGAGGTATAAAA
CAGGACATAAAAAGTTTTAA

Downstream 100 bases:

>100_bases
TGCTATTCTCCCCCCTTTGCTTTTTAAGTATTCAAATGATTGCCATTTTTAGATAATGAGAGTAAGTAATGTTAAGAAGA
TAGCATGAGAAAGTATTTAC

Product: exotoxin G

Products: NA

Alternate protein names: Pyrogenic exotoxin G; SPE G

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKTNILTIIILSCVFSYGSQLAYADENLKDLKRSLRFAYNITPCDYENVEIAFVTTNSIHINTKQKRSECILYVDSIVSL
GITDQFIKGDKVDVFGLPYNFSPPYVDNIYGGIVKHSNQGNKSLQFVGILNQDGKETYLPSEAVRIKKKQFTLQEFDFKI
RKFLMEKYNIYDSESRYTSGSLFLATKDSKHYEVDLFNKDDKLLSRDSFFKRYKDNKIFNSEEISHFDIYLKTH

Sequences:

>Translated_234_residues
MKTNILTIIILSCVFSYGSQLAYADENLKDLKRSLRFAYNITPCDYENVEIAFVTTNSIHINTKQKRSECILYVDSIVSL
GITDQFIKGDKVDVFGLPYNFSPPYVDNIYGGIVKHSNQGNKSLQFVGILNQDGKETYLPSEAVRIKKKQFTLQEFDFKI
RKFLMEKYNIYDSESRYTSGSLFLATKDSKHYEVDLFNKDDKLLSRDSFFKRYKDNKIFNSEEISHFDIYLKTH
>Mature_234_residues
MKTNILTIIILSCVFSYGSQLAYADENLKDLKRSLRFAYNITPCDYENVEIAFVTTNSIHINTKQKRSECILYVDSIVSL
GITDQFIKGDKVDVFGLPYNFSPPYVDNIYGGIVKHSNQGNKSLQFVGILNQDGKETYLPSEAVRIKKKQFTLQEFDFKI
RKFLMEKYNIYDSESRYTSGSLFLATKDSKHYEVDLFNKDDKLLSRDSFFKRYKDNKIFNSEEISHFDIYLKTH

Specific function: Mitogenic for human peripheral blood lymphocytes

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the staphylococcal/streptococcal toxin family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SPEG_STRP1 (Q9X5C7)

Other databases:

- EMBL:   AF124499
- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268582.1
- RefSeq:   YP_281546.1
- ProteinModelPortal:   Q9X5C7
- SMR:   Q9X5C7
- EnsemblBacteria:   EBSTRT00000000657
- EnsemblBacteria:   EBSTRT00000027767
- GeneID:   3572727
- GeneID:   900527
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0212
- KEGG:   spz:M5005_Spy_0182
- GeneTree:   EBGT00050000028723
- HOGENOM:   HBG698126
- OMA:   NIHINTG
- ProtClustDB:   CLSK698258
- BioCyc:   SPYO160490:SPY0212-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0182-MONOMER
- GO:   GO:0009405
- InterPro:   IPR008992
- InterPro:   IPR006126
- InterPro:   IPR006173
- InterPro:   IPR016091
- InterPro:   IPR013307
- InterPro:   IPR006123
- Gene3D:   G3DSA:3.10.20.120
- PRINTS:   PR01898

Pfam domain/function: PF02876 Stap_Strp_tox_C; PF01123 Stap_Strp_toxin; SSF50203 Bact_endotox; SSF54334 Stap/Strep_toxin

EC number: NA

Molecular weight: Translated: 27262; Mature: 27262

Theoretical pI: Translated: 8.39; Mature: 8.39

Prosite motif: PS00277 STAPH_STREP_TOXIN_1; PS00278 STAPH_STREP_TOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNILTIIILSCVFSYGSQLAYADENLKDLKRSLRFAYNITPCDYENVEIAFVTTNSIH
CCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHEEEECCCCCCCCEEEEEEEECEEE
INTKQKRSECILYVDSIVSLGITDQFIKGDKVDVFGLPYNFSPPYVDNIYGGIVKHSNQG
EECCCCCCCEEEEEEHHHHCCCCHHHHCCCCEEEEECCCCCCCCCHHHHHHCEEEECCCC
NKSLQFVGILNQDGKETYLPSEAVRIKKKQFTLQEFDFKIRKFLMEKYNIYDSESRYTSG
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SLFLATKDSKHYEVDLFNKDDKLLSRDSFFKRYKDNKIFNSEEISHFDIYLKTH
EEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC
>Mature Secondary Structure
MKTNILTIIILSCVFSYGSQLAYADENLKDLKRSLRFAYNITPCDYENVEIAFVTTNSIH
CCCHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHEEEECCCCCCCCEEEEEEEECEEE
INTKQKRSECILYVDSIVSLGITDQFIKGDKVDVFGLPYNFSPPYVDNIYGGIVKHSNQG
EECCCCCCCEEEEEEHHHHCCCCHHHHCCCCEEEEECCCCCCCCCHHHHHHCEEEECCCC
NKSLQFVGILNQDGKETYLPSEAVRIKKKQFTLQEFDFKIRKFLMEKYNIYDSESRYTSG
CCEEEEEEEECCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SLFLATKDSKHYEVDLFNKDDKLLSRDSFFKRYKDNKIFNSEEISHFDIYLKTH
EEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9874566; 11296296