Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is licR [H]

Identifier: 15674386

GI number: 15674386

Start: 164979

End: 166622

Strand: Direct

Name: licR [H]

Synonym: SPy_0181

Alternate gene names: 15674386

Gene position: 164979-166622 (Clockwise)

Preceding gene: 15674385

Following gene: 15674387

Centisome position: 8.91

GC content: 36.92

Gene sequence:

>1644_bases
ATGATTTTAGATAAAAAGAGTTATGACTTGCTGTCTTATTTACTTAAACTAGAAACACCTGAGACAGTTATGGCCATTTC
TCATGCTTTAAATCAGTCACGTCGTAAAGTTTATTACCAGCTTGACAAAATTAATCAGGCTTTGCCAAAGGGAGTAGATC
AGATTATCTCTTATCCTAGACTTGGCATTCTTTTAACGGCGGATCAAAAAGCTGCTTGTCGCTTATTATTAGAAGAAGTG
ACTGATTATAATTATGTCATGAAAAGTGATGAGCGCAGACGACTATCCTCGATTTATATTGCGGTTTCCACTGAGCGCGT
GACCATTGATAAACTGATGCAGATCAATGATGTGTCTCGTAACACGATTTTAAATGACCTGACTGAGTTAAGGGAAGAAC
TGGAAGACAAACAATACAAGATTCAGCTTCATGCGACAAAGGCTAGGGGATATTATTTTGGTTGTCATCCAATGGCTCTT
ATTCAATACCTGTACAAATTGTTAGTGGACGTTTACCAAGGTGGCAATACTAGCTTTATTGATATATTCAACCGTAAACT
CTCAGAGATACAAGGCTTATCGGTTTATTTTTCTAAAGATATTTTGACCTATTTTCATGAGTATCTTTTTTTATCTCAAG
CTAGTTTAGGAAAGACAATTAATACCCAAGATAGCCAATTCATGTTGCAGATTTTACCTTTCATGCTTTTAAGTTATCGT
AATATGCGTCTTGATTCAGAAACAAAGTCTGCTCTTAAACAAGAATTTCATTTGATTTGGAAACGTAAAGAATATCACAT
TGCTCAGGACTTAGCTAGAGAGCTTTACCATAATTTTAAGCTTCATTTGGATGATATCGAAGTTAGTATGGTAGCGATGT
TGATGTTGTCTTTTCGAAAAGATCAAGATCATCACGTGGAAAGTCAAGATTACGATGACATGCGAGCAACCATTAGTCAC
TTTATTGACCAGTTGGAGAGCCGTTATCAGTTACATTTCACGCATAAACAGGATTTGCTGAAGCGGTTGACGACCCATTG
TAAGGCGCTCGTTTACCGTAAAGCTTATGGGATTTTTTTAGTTAATCCCTTAACAGACCATGTTAAAGAAAAATACGAAG
AATTGTTTGCTATGACTCAATCTTGTGCCACTATTTTGGAACAAGATTGGACGATTAGCTTGACAGACGATGATATTGCC
TACTTGACTATCCATCTTGGGGGAGAGCTGCGTCACAATAATACAGAGCAAGAAAAGACCAAACTCGTTATTGTTTCAGA
TGATGGGATAGGCATTCAAAAGTTATTGTTCAAACAGTGTCAAAGGTATCTAGCAAATGGTCAGATTGAAGCTGTTTTTA
CGACAGAACAGTATCAGAGTGTTTACGATCTTTTAGCAGTCGATATGATTGTTGCTACTACAGATACGCTAAAGACTAAA
ATCCCGATGCTTATTGTTAACCCTATTTTAAGTGACGATGATATCATCAAATTGATACGCTTTTCAAAGCAAGGACGCTT
GAGTGAGCACTCCCGCTTTTCTACAGAGCTCACAAAAGCAATTGAAGCTGTTGTAAAAGATGAATCAGATCGTTATGCCT
TGGTTTCTAAAATTGAAAAACTCATTCATCGCGAGCTGCTATGA

Upstream 100 bases:

>100_bases
ATCTTATTATGGTGAGTTTTTAAAAACTTGGCTGCGCAGTCACTGAAATCATGATAAAATAAGCAAGGATGGATTTTCAG
AGAGGAGGTTTGTAAACATG

Downstream 100 bases:

>100_bases
GTAAGTGTTAAGTCGTCAAAGTACCTCAGTTTTCTATGACATAGAAAAATATAACTGAGGTTTTTAATATAGCTTTGAAT
ACAGTATTGATGCGAGATAC

Product: putative transcriptional regulator

Products: NA

Alternate protein names: Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MILDKKSYDLLSYLLKLETPETVMAISHALNQSRRKVYYQLDKINQALPKGVDQIISYPRLGILLTADQKAACRLLLEEV
TDYNYVMKSDERRRLSSIYIAVSTERVTIDKLMQINDVSRNTILNDLTELREELEDKQYKIQLHATKARGYYFGCHPMAL
IQYLYKLLVDVYQGGNTSFIDIFNRKLSEIQGLSVYFSKDILTYFHEYLFLSQASLGKTINTQDSQFMLQILPFMLLSYR
NMRLDSETKSALKQEFHLIWKRKEYHIAQDLARELYHNFKLHLDDIEVSMVAMLMLSFRKDQDHHVESQDYDDMRATISH
FIDQLESRYQLHFTHKQDLLKRLTTHCKALVYRKAYGIFLVNPLTDHVKEKYEELFAMTQSCATILEQDWTISLTDDDIA
YLTIHLGGELRHNNTEQEKTKLVIVSDDGIGIQKLLFKQCQRYLANGQIEAVFTTEQYQSVYDLLAVDMIVATTDTLKTK
IPMLIVNPILSDDDIIKLIRFSKQGRLSEHSRFSTELTKAIEAVVKDESDRYALVSKIEKLIHRELL

Sequences:

>Translated_547_residues
MILDKKSYDLLSYLLKLETPETVMAISHALNQSRRKVYYQLDKINQALPKGVDQIISYPRLGILLTADQKAACRLLLEEV
TDYNYVMKSDERRRLSSIYIAVSTERVTIDKLMQINDVSRNTILNDLTELREELEDKQYKIQLHATKARGYYFGCHPMAL
IQYLYKLLVDVYQGGNTSFIDIFNRKLSEIQGLSVYFSKDILTYFHEYLFLSQASLGKTINTQDSQFMLQILPFMLLSYR
NMRLDSETKSALKQEFHLIWKRKEYHIAQDLARELYHNFKLHLDDIEVSMVAMLMLSFRKDQDHHVESQDYDDMRATISH
FIDQLESRYQLHFTHKQDLLKRLTTHCKALVYRKAYGIFLVNPLTDHVKEKYEELFAMTQSCATILEQDWTISLTDDDIA
YLTIHLGGELRHNNTEQEKTKLVIVSDDGIGIQKLLFKQCQRYLANGQIEAVFTTEQYQSVYDLLAVDMIVATTDTLKTK
IPMLIVNPILSDDDIIKLIRFSKQGRLSEHSRFSTELTKAIEAVVKDESDRYALVSKIEKLIHRELL
>Mature_547_residues
MILDKKSYDLLSYLLKLETPETVMAISHALNQSRRKVYYQLDKINQALPKGVDQIISYPRLGILLTADQKAACRLLLEEV
TDYNYVMKSDERRRLSSIYIAVSTERVTIDKLMQINDVSRNTILNDLTELREELEDKQYKIQLHATKARGYYFGCHPMAL
IQYLYKLLVDVYQGGNTSFIDIFNRKLSEIQGLSVYFSKDILTYFHEYLFLSQASLGKTINTQDSQFMLQILPFMLLSYR
NMRLDSETKSALKQEFHLIWKRKEYHIAQDLARELYHNFKLHLDDIEVSMVAMLMLSFRKDQDHHVESQDYDDMRATISH
FIDQLESRYQLHFTHKQDLLKRLTTHCKALVYRKAYGIFLVNPLTDHVKEKYEELFAMTQSCATILEQDWTISLTDDDIA
YLTIHLGGELRHNNTEQEKTKLVIVSDDGIGIQKLLFKQCQRYLANGQIEAVFTTEQYQSVYDLLAVDMIVATTDTLKTK
IPMLIVNPILSDDDIIKLIRFSKQGRLSEHSRFSTELTKAIEAVVKDESDRYALVSKIEKLIHRELL

Specific function: Positive regulator of the licABCH operon [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF00359 PTS_EIIA_2; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 63932; Mature: 63932

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDKKSYDLLSYLLKLETPETVMAISHALNQSRRKVYYQLDKINQALPKGVDQIISYPR
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGILLTADQKAACRLLLEEVTDYNYVMKSDERRRLSSIYIAVSTERVTIDKLMQINDVSR
CEEEEECCCHHHHHHHHHHHCCCHHHCCCCHHHHHEEEEEEEECCEEEHHHHHHHHCCHH
NTILNDLTELREELEDKQYKIQLHATKARGYYFGCHPMALIQYLYKLLVDVYQGGNTSFI
HHHHHHHHHHHHHHCCCEEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCHH
DIFNRKLSEIQGLSVYFSKDILTYFHEYLFLSQASLGKTINTQDSQFMLQILPFMLLSYR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
NMRLDSETKSALKQEFHLIWKRKEYHIAQDLARELYHNFKLHLDDIEVSMVAMLMLSFRK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECHHHHHHHHHHHHHHCC
DQDHHVESQDYDDMRATISHFIDQLESRYQLHFTHKQDLLKRLTTHCKALVYRKAYGIFL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHCCEEE
VNPLTDHVKEKYEELFAMTQSCATILEQDWTISLTDDDIAYLTIHLGGELRHNNTEQEKT
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCEECCCCCCCHHE
KLVIVSDDGIGIQKLLFKQCQRYLANGQIEAVFTTEQYQSVYDLLAVDMIVATTDTLKTK
EEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHC
IPMLIVNPILSDDDIIKLIRFSKQGRLSEHSRFSTELTKAIEAVVKDESDRYALVSKIEK
CCCEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LIHRELL
HHHHHCC
>Mature Secondary Structure
MILDKKSYDLLSYLLKLETPETVMAISHALNQSRRKVYYQLDKINQALPKGVDQIISYPR
CCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGILLTADQKAACRLLLEEVTDYNYVMKSDERRRLSSIYIAVSTERVTIDKLMQINDVSR
CEEEEECCCHHHHHHHHHHHCCCHHHCCCCHHHHHEEEEEEEECCEEEHHHHHHHHCCHH
NTILNDLTELREELEDKQYKIQLHATKARGYYFGCHPMALIQYLYKLLVDVYQGGNTSFI
HHHHHHHHHHHHHHCCCEEEEEEEEEECCCEEECCCHHHHHHHHHHHHHHHHCCCCCCHH
DIFNRKLSEIQGLSVYFSKDILTYFHEYLFLSQASLGKTINTQDSQFMLQILPFMLLSYR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
NMRLDSETKSALKQEFHLIWKRKEYHIAQDLARELYHNFKLHLDDIEVSMVAMLMLSFRK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEECHHHHHHHHHHHHHHCC
DQDHHVESQDYDDMRATISHFIDQLESRYQLHFTHKQDLLKRLTTHCKALVYRKAYGIFL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHCCEEE
VNPLTDHVKEKYEELFAMTQSCATILEQDWTISLTDDDIAYLTIHLGGELRHNNTEQEKT
ECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEEEECCEECCCCCCCHHE
KLVIVSDDGIGIQKLLFKQCQRYLANGQIEAVFTTEQYQSVYDLLAVDMIVATTDTLKTK
EEEEEECCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHCHHHHHHC
IPMLIVNPILSDDDIIKLIRFSKQGRLSEHSRFSTELTKAIEAVVKDESDRYALVSKIEK
CCCEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LIHRELL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8990303; 8969509; 9384377; 10438772 [H]