Click here to switch to the map view.

The map label for this gene is ntpA

Identifier: 15674362

GI number: 15674362

Start: 139268

End: 141043

Strand: Direct

Name: ntpA

Synonym: SPy_0154

Alternate gene names: 15674362

Gene position: 139268-141043 (Clockwise)

Preceding gene: 15674361

Following gene: 15674363

Centisome position: 7.52

GC content: 46.51

Gene sequence:

>1776_bases
GTGAACCAAGGAAAAATAATAACCGTTTCGGGACCTCTTGTTGTGGCTTCTGGGATGCAAGAAGCTAATATTCAAGATAT
TTGTCGTGTGGGACATCTTGGCTTAGTCGGAGAAATTATTGAAATGCGTCGCGATCAAGCGTCTATTCAGGTTTATGAGG
AAACATCAGGGATCGGTCCAGGAGAACCAGTAGTGACTACTGGTTGTCCTTTGTCGGTCGAGTTAGGCCCGGGCCTGATT
TCAGAAATGTTTGACGGTATTCAGCGACCGCTTGATCGTTTTCAAAAAGCAACGGACAGCGACTTTTTAATCCGTGGTGT
GGCTATCCCAAGTCTTGATCGAAAGGCTAAGTGGGCATTTATTCCCAAGCTAAGTGTTGGTCAAGAAGTAGTTGCAGGTG
ATATTTTAGGAACTGTGCAAGAAACAGCTGTCATTGAGCACCGTATCATGGTTCCTTATAAAGTTTCAGGGACCTTGGTG
GCTATTCATGCAGGGGACTTCACAGTAACAGATACAGTTTATGAAATTAAGCAGGAAGACGGTTCCATTTACCAAGGTAG
CCTCATGCAGACTTGGCCAGTTCGTCAAAGTCGCCCTGTTGCTCAAAAGCTTATCCCAGTCGAACCTTTGGTTACAGGTC
AACGGGTTATTGACACCTTTTTCCCTGTTACAAAAGGTGGTGCCGCTGCCGTTCCTGGACCATTTGGGGCAGGAAAAACA
GTTGTGCAGCATCAAATAGCTAAATTTGCCAACGTTGATATTGTTATTTATGTCGGTTGTGGGGAACGCGGCAACGAGAT
GACCGACGTTTTGAATGAGTTTCCAGAGTTAATTGACCCAAATACAGGCCAGTCCATTATGGAGCGCACGGTGTTAATTG
CAAACACCTCTAATATGCCAGTAGCAGCGCGTGAAGCGTCGATTTACACAGGTATTACCATTGCCGAATATTTCCGTGAT
ATGGGCTATTCTGTGGCTATCATGGCAGACTCGACATCACGTTGGGCAGAAGCTCTGCGCGAGATGTCAGGACGCCTACA
AGAAATGCCTGGTGATGAAGGCTACCCGGCTTACTTAGGGAGTCGTATTGCCGAATATTATGAACGGGCTGGTCGTGTTC
GGACCTTGGGAAGTCAAGAACGTGAGGGAACCATTACAGCCATCGGCGCGGTTTCTCCTCCTGGAGGGGATATTTCAGAG
CCTGTCACTCAAAACACCCTTCGGATTGTCAAAGTTTTCTGGGGGCTCGACGCGCCTCTTGCGCAACGGCGTCACTTCCC
AGCGATTAACTGGCTGACGTCTTATTCATTGTATCAAGATGATGTAGGAAGCTATATTGACCGTAAACAGCAATCTAATT
GGTCCAACAAGGTAACTCGTGCCATGGCTATTTTGCAGCGTGAAGCCAGTCTAGAAGAAATTGTACGCTTGGTGGGGCTT
GATTCACTGTCTGAACAAGATCGTTTGACCATGGCTGTTGCCCGGCAAATTCGGGAGGATTATCTCCAGCAAAATGCCTT
TGATTCGGTGGATACCTTTACTTCCTTTCCGAAACAAGAGGCCATGCTAACCAATATTTTGACCTTTAATGAGGAAGCCA
GCAAAGCCCTTTCTTTGGGAGCTTATTTTAATGAGATTATGGAAGGCACTGCTCAGGTACGCGATCGCATCGCACGCAGC
AAATTTATCCCAGAAGAAAACTTAGAGCAGATTAAAGGGCTTACTCAGAAGGTTACCAAAGAGATTCACCACGTTTTAGC
AAAGGGAGGAATTTAG

Upstream 100 bases:

>100_bases
GAACGCATAGGATAGTTTGCTGACTATTCAAAATAGTCACATTAAACCTTGACAGTATAGATTAGTTAGTATGATTTGGA
AAAAATAAAGGAGGAAAAAG

Downstream 100 bases:

>100_bases
ATGAGCGTTCTCAAAGAATATCGGACGGTTAGCGAAGTGGTTGGCCCTTTGATGATTGTTGATCAAGTTGCAGGAGTGCA
CTACAACGAATTGGTAGATA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLI
SEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLV
AIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISE
PVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQQSNWSNKVTRAMAILQREASLEEIVRLVGL
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARS
KFIPEENLEQIKGLTQKVTKEIHHVLAKGGI

Sequences:

>Translated_591_residues
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLI
SEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLV
AIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISE
PVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQQSNWSNKVTRAMAILQREASLEEIVRLVGL
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARS
KFIPEENLEQIKGLTQKVTKEIHHVLAKGGI
>Mature_591_residues
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGPGEPVVTTGCPLSVELGPGLI
SEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAFIPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLV
AIHAGDFTVTDTVYEIKQEDGSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMPVAAREASIYTGITIAEYFRD
MGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLGSRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISE
PVTQNTLRIVKVFWGLDAPLAQRRHFPAINWLTSYSLYQDDVGSYIDRKQQSNWSNKVTRAMAILQREASLEEIVRLVGL
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLGAYFNEIMEGTAQVRDRIARS
KFIPEENLEQIKGLTQKVTKEIHHVLAKGGI

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI19913424, Length=562, Percent_Identity=53.55871886121, Blast_Score=600, Evalue=1e-171,
Organism=Homo sapiens, GI32189394, Length=316, Percent_Identity=31.6455696202532, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI19913428, Length=233, Percent_Identity=29.1845493562232, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI19913426, Length=233, Percent_Identity=29.6137339055794, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI50345984, Length=243, Percent_Identity=27.5720164609054, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4757810, Length=243, Percent_Identity=27.5720164609054, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790170, Length=348, Percent_Identity=28.735632183908, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788251, Length=308, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790172, Length=236, Percent_Identity=27.5423728813559, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17565854, Length=559, Percent_Identity=52.9516994633274, Blast_Score=587, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI25144756, Length=316, Percent_Identity=31.6455696202532, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17510931, Length=225, Percent_Identity=30.6666666666667, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17570191, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71988080, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71988074, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71988063, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6320016, Length=357, Percent_Identity=46.7787114845938, Blast_Score=327, Evalue=3e-90,
Organism=Saccharomyces cerevisiae, GI6322581, Length=360, Percent_Identity=29.7222222222222, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6319603, Length=240, Percent_Identity=30.8333333333333, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6319370, Length=236, Percent_Identity=25.8474576271186, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583988, Length=562, Percent_Identity=53.0249110320285, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24583986, Length=562, Percent_Identity=53.0249110320285, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24583984, Length=562, Percent_Identity=53.0249110320285, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24583992, Length=559, Percent_Identity=52.9516994633274, Blast_Score=588, Evalue=1e-168,
Organism=Drosophila melanogaster, GI20129479, Length=535, Percent_Identity=52.3364485981308, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI28574560, Length=319, Percent_Identity=34.4827586206897, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24638766, Length=314, Percent_Identity=32.1656050955414, Blast_Score=126, Evalue=5e-29,
Organism=Drosophila melanogaster, GI281361666, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24646341, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17136796, Length=233, Percent_Identity=30.0429184549356, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24658560, Length=247, Percent_Identity=27.1255060728745, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): VATA_STRP1 (Q9A1Q3)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_268536.1
- RefSeq:   YP_281495.1
- ProteinModelPortal:   Q9A1Q3
- SMR:   Q9A1Q3
- EnsemblBacteria:   EBSTRT00000000823
- EnsemblBacteria:   EBSTRT00000027564
- GeneID:   3572793
- GeneID:   900480
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_0154
- KEGG:   spz:M5005_Spy_0131
- GeneTree:   EBGT00050000027468
- HOGENOM:   HBG288114
- OMA:   KITWNVI
- ProtClustDB:   PRK04192
- BioCyc:   SPYO160490:SPY0154-MONOMER
- BioCyc:   SPYO293653:M5005_SPY0131-MONOMER
- HAMAP:   MF_00309
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878
- SMART:   SM00382

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 64968; Mature: 64968

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGP
CCCCCEEEEECCEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
GEPVVTTGCPLSVELGPGLISEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAF
CCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEE
IPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLVAIHAGDFTVTDTVYEIKQED
CCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEECCCEEEHHHHHHHHHCC
GSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
CCEEECCCCEECCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHH
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMP
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITIAEYFRDMGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLG
EEECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPL
HHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
AQRRHFPAINWLTSYSLYQDDVGSYIDRKQQSNWSNKVTRAMAILQREASLEEIVRLVGL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHCC
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
AYFNEIMEGTAQVRDRIARSKFIPEENLEQIKGLTQKVTKEIHHVLAKGGI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNQGKIITVSGPLVVASGMQEANIQDICRVGHLGLVGEIIEMRRDQASIQVYEETSGIGP
CCCCCEEEEECCEEEECCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCCCC
GEPVVTTGCPLSVELGPGLISEMFDGIQRPLDRFQKATDSDFLIRGVAIPSLDRKAKWAF
CCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEE
IPKLSVGQEVVAGDILGTVQETAVIEHRIMVPYKVSGTLVAIHAGDFTVTDTVYEIKQED
CCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEECCCEEEHHHHHHHHHCC
GSIYQGSLMQTWPVRQSRPVAQKLIPVEPLVTGQRVIDTFFPVTKGGAAAVPGPFGAGKT
CCEEECCCCEECCCCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCHH
VVQHQIAKFANVDIVIYVGCGERGNEMTDVLNEFPELIDPNTGQSIMERTVLIANTSNMP
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCEEEEEECCCCC
VAAREASIYTGITIAEYFRDMGYSVAIMADSTSRWAEALREMSGRLQEMPGDEGYPAYLG
EEECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
SRIAEYYERAGRVRTLGSQEREGTITAIGAVSPPGGDISEPVTQNTLRIVKVFWGLDAPL
HHHHHHHHHCCCEEECCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCH
AQRRHFPAINWLTSYSLYQDDVGSYIDRKQQSNWSNKVTRAMAILQREASLEEIVRLVGL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHCC
DSLSEQDRLTMAVARQIREDYLQQNAFDSVDTFTSFPKQEAMLTNILTFNEEASKALSLG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
AYFNEIMEGTAQVRDRIARSKFIPEENLEQIKGLTQKVTKEIHHVLAKGGI
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296