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The map label for this gene is ntpI [H]

Identifier: 15674358

GI number: 15674358

Start: 134603

End: 136603

Strand: Direct

Name: ntpI [H]

Synonym: SPy_0148

Alternate gene names: 15674358

Gene position: 134603-136603 (Clockwise)

Preceding gene: 15674357

Following gene: 15674359

Centisome position: 7.27

GC content: 37.08

Gene sequence:

>2001_bases
ATGGCCATTAGTCAAATGAAAAAGCTGGCAATGGTTTTTGAAAAAGATTATCTTGATCTTGTTTTAAAAACACTTCAACA
ATCTCAATTAGTTGAAGTTCGTGACATGAAGCAACTAAAACATTGGCAAGATGCTTTTAACAAAGGCAACGTCAAGTTGC
CACAAATCGTCCAATACGATCTGACGCATCAAAAACCTCTACTAGATGATGAAGCTTTACAATACCTTTTACAAAGCCAA
CAAGAGTTAGAAAACGGCCTTGCTAGCTTATCAGCGTTTTTACCACCAATAGGAAAGTTAACAGCCTTGAGACAAAAAAC
GCCATCTCTTTCGTTTAAACAGTTCGAAGAACGCCATCGACAACAAGCAGCTCAAACGGCTTTGAAAATGATGTCACAAA
AGATAGAGCGACTAGAGCAGCTGCAAAGCAAAATAGACCAGCTAACAGAATACTGTCAGGAGTTAGAAAAGTGGCGTTCC
TTGACTGTTTTGCCTCAGGACTTAGCGCAATTTCATTTTTTGTCGGCAAGAGTTGGAACGATTCCTAGTACAGCAAATAA
TCATTTTTATCATCAGCTAAAGCAGCACAAAGGTCTTTTTATTGAGGAAGTATACCATACAGAATTTGAGTACGGCCTTG
TCTTATTTTGGCAAGCACAAGATACGATTCATTTACAGAAATATCAGTTTAAACCCTTATTATATAAAGAACAGTTACTG
CCATCAGAACAACTTCGTATAAACAAAGAGTTACTAACGAATTGGCTAGCTGAAAAAGATAGTCTACTAAAAGAGCTTAG
GCAGTCTCAAAAGATACTGGCACAGTTACAGGTTGAAATAGACTATGTCCTTAGTCAGTATCAACGGCAGCAAACTAAAA
AGCAATTACTCGGTACAAGACATCTAATAGCCTTAGAAGGGTGGATAGAAGCTGATTCGGTTAACCAATTAAAAGGGCTA
ATGACTAAGACACTAGGTGATATGTTTTATCTGGATAGTTACGATGTCACGCCAGACGATTGGGAAGATGTTCCCATTAA
GCTACGTAATCACCGCTACATTGCACCGTTTGAATTGGTTACAGAAATGTACGCTTTGCCAAAATATCAAGAAAAAGATC
CGACACCTTTTTTAGCTCCTTTATACCTTACTTTTTTTGGCATGATGGTAGCTGATTTGGGCTATGGTTTGTTGCTATAT
GCTGTGACACTAGCTGCATTGGTCTTTTTTAATCTCCAAAAAACCAGTAAACGGTTAGTGACCTTCTTTAATATTTTAGC
TATTTCAGTAGCCATATGGGGGCTTATTTACGGTTCTTTCTTTGGTTTTGACTTACCTGTGGCATTATTATCAACTAAAA
CGGATGTGATTACTATTTTGGTTGTTTCTTTGCTATTTGGGTTTGTTACACTTATATTTGGGCTTTTGTTAGGAGCATGG
CAACAAGTAAGGATGAAAGCATATGCTACGGCCTATACGTCAAGTCTAGCTTGGACTTTTATTTTATTAGGTCTGCTGTT
ATTTATTCTTGGTAAGAATGTATCTGGCCTTGCTTACTTATCGGTTATTGGTAAGTGGCTTGCATTGGGCAATGCCTTTG
GGATTTTGGTTGTTTCTTTACTAAAAAGCAAAAGCCTTTTAGGTCTAGGTAGTGGATTATATAATTTATATGGCATTAGC
TCTTACTTAAGTGATTTGGTTAGCTTTACTCGTCTAATGGCATTAGGGCTTTCTGGAGCTAGTATTGGAGCGGCTTTTAA
CATGATTGTTGGGATTTTTCCACCAGTCACGCGCTTTACAGTAGGTATCTTTATTTTTATTCTTTTGCATGCGATCAATA
TTTTCTTATCAATGCTTTCAGGATATGTGCATGGTGCTCGTCTTATTTTCGTAGAGTTTTTTGGAAAATTTTATGAAGGT
GGAGGAAAAGCTTTCAATCCTTTAAAGTTAGCTGATAATTATGTCAATGTCAATGAAGAAACAGATTTGGAGGACAATTA
A

Upstream 100 bases:

>100_bases
AAAAAGAGATTAGCGACGCAACAGCTAGCCCTTCATGCCATTTTAGAAGAGCATAAGCTAACCGTTGTTAGGGAGTTAGT
GGATAAGGTGGTGGAGACAT

Downstream 100 bases:

>100_bases
CATGGAACATTTAGCACATTATTTTACAGCACATGGTGGCGTTTTCTTCGCAGCCTTAGGAATTGTTTTAGCCGTAGCTC
TTAGTGGCATGGGCTCAGCT

Product: V-type ATP synthase subunit I

Products: ADP; phosphate; H+

Alternate protein names: Na(+)-translocating ATPase subunit I; V-type sodium pump subunit I [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MAISQMKKLAMVFEKDYLDLVLKTLQQSQLVEVRDMKQLKHWQDAFNKGNVKLPQIVQYDLTHQKPLLDDEALQYLLQSQ
QELENGLASLSAFLPPIGKLTALRQKTPSLSFKQFEERHRQQAAQTALKMMSQKIERLEQLQSKIDQLTEYCQELEKWRS
LTVLPQDLAQFHFLSARVGTIPSTANNHFYHQLKQHKGLFIEEVYHTEFEYGLVLFWQAQDTIHLQKYQFKPLLYKEQLL
PSEQLRINKELLTNWLAEKDSLLKELRQSQKILAQLQVEIDYVLSQYQRQQTKKQLLGTRHLIALEGWIEADSVNQLKGL
MTKTLGDMFYLDSYDVTPDDWEDVPIKLRNHRYIAPFELVTEMYALPKYQEKDPTPFLAPLYLTFFGMMVADLGYGLLLY
AVTLAALVFFNLQKTSKRLVTFFNILAISVAIWGLIYGSFFGFDLPVALLSTKTDVITILVVSLLFGFVTLIFGLLLGAW
QQVRMKAYATAYTSSLAWTFILLGLLLFILGKNVSGLAYLSVIGKWLALGNAFGILVVSLLKSKSLLGLGSGLYNLYGIS
SYLSDLVSFTRLMALGLSGASIGAAFNMIVGIFPPVTRFTVGIFIFILLHAINIFLSMLSGYVHGARLIFVEFFGKFYEG
GGKAFNPLKLADNYVNVNEETDLEDN

Sequences:

>Translated_666_residues
MAISQMKKLAMVFEKDYLDLVLKTLQQSQLVEVRDMKQLKHWQDAFNKGNVKLPQIVQYDLTHQKPLLDDEALQYLLQSQ
QELENGLASLSAFLPPIGKLTALRQKTPSLSFKQFEERHRQQAAQTALKMMSQKIERLEQLQSKIDQLTEYCQELEKWRS
LTVLPQDLAQFHFLSARVGTIPSTANNHFYHQLKQHKGLFIEEVYHTEFEYGLVLFWQAQDTIHLQKYQFKPLLYKEQLL
PSEQLRINKELLTNWLAEKDSLLKELRQSQKILAQLQVEIDYVLSQYQRQQTKKQLLGTRHLIALEGWIEADSVNQLKGL
MTKTLGDMFYLDSYDVTPDDWEDVPIKLRNHRYIAPFELVTEMYALPKYQEKDPTPFLAPLYLTFFGMMVADLGYGLLLY
AVTLAALVFFNLQKTSKRLVTFFNILAISVAIWGLIYGSFFGFDLPVALLSTKTDVITILVVSLLFGFVTLIFGLLLGAW
QQVRMKAYATAYTSSLAWTFILLGLLLFILGKNVSGLAYLSVIGKWLALGNAFGILVVSLLKSKSLLGLGSGLYNLYGIS
SYLSDLVSFTRLMALGLSGASIGAAFNMIVGIFPPVTRFTVGIFIFILLHAINIFLSMLSGYVHGARLIFVEFFGKFYEG
GGKAFNPLKLADNYVNVNEETDLEDN
>Mature_665_residues
AISQMKKLAMVFEKDYLDLVLKTLQQSQLVEVRDMKQLKHWQDAFNKGNVKLPQIVQYDLTHQKPLLDDEALQYLLQSQQ
ELENGLASLSAFLPPIGKLTALRQKTPSLSFKQFEERHRQQAAQTALKMMSQKIERLEQLQSKIDQLTEYCQELEKWRSL
TVLPQDLAQFHFLSARVGTIPSTANNHFYHQLKQHKGLFIEEVYHTEFEYGLVLFWQAQDTIHLQKYQFKPLLYKEQLLP
SEQLRINKELLTNWLAEKDSLLKELRQSQKILAQLQVEIDYVLSQYQRQQTKKQLLGTRHLIALEGWIEADSVNQLKGLM
TKTLGDMFYLDSYDVTPDDWEDVPIKLRNHRYIAPFELVTEMYALPKYQEKDPTPFLAPLYLTFFGMMVADLGYGLLLYA
VTLAALVFFNLQKTSKRLVTFFNILAISVAIWGLIYGSFFGFDLPVALLSTKTDVITILVVSLLFGFVTLIFGLLLGAWQ
QVRMKAYATAYTSSLAWTFILLGLLLFILGKNVSGLAYLSVIGKWLALGNAFGILVVSLLKSKSLLGLGSGLYNLYGISS
YLSDLVSFTRLMALGLSGASIGAAFNMIVGIFPPVTRFTVGIFIFILLHAINIFLSMLSGYVHGARLIFVEFFGKFYEGG
GKAFNPLKLADNYVNVNEETDLEDN

Specific function: Involved in ATP-driven sodium extrusion [H]

COG id: COG1269

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase 116 kDa subunit family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002490 [H]

Pfam domain/function: PF01496 V_ATPase_I [H]

EC number: 3.6.3.14

Molecular weight: Translated: 75897; Mature: 75766

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCC
>Mature Secondary Structure 
AISQMKKLAMVFEKDYLDLVLKTLQQSQLVEVRDMKQLKHWQDAFNKGNVKLPQIVQYD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHC
LTHQKPLLDDEALQYLLQSQQELENGLASLSAFLPPIGKLTALRQKTPSLSFKQFEERHR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHH
QQAAQTALKMMSQKIERLEQLQSKIDQLTEYCQELEKWRSLTVLPQDLAQFHFLSARVGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
IPSTANNHFYHQLKQHKGLFIEEVYHTEFEYGLVLFWQAQDTIHLQKYQFKPLLYKEQLL
CCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEECCCCEEHHHHCCCCHHHHHHCC
PSEQLRINKELLTNWLAEKDSLLKELRQSQKILAQLQVEIDYVLSQYQRQQTKKQLLGTR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
HLIALEGWIEADSVNQLKGLMTKTLGDMFYLDSYDVTPDDWEDVPIKLRNHRYIAPFELV
HHEEEECCCCCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEECCCCCCCHHHHH
TEMYALPKYQEKDPTPFLAPLYLTFFGMMVADLGYGLLLYAVTLAALVFFNLQKTSKRLV
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFFNILAISVAIWGLIYGSFFGFDLPVALLSTKTDVITILVVSLLFGFVTLIFGLLLGAW
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQVRMKAYATAYTSSLAWTFILLGLLLFILGKNVSGLAYLSVIGKWLALGNAFGILVVSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LKSKSLLGLGSGLYNLYGISSYLSDLVSFTRLMALGLSGASIGAAFNMIVGIFPPVTRFT
HHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHH
VGIFIFILLHAINIFLSMLSGYVHGARLIFVEFFGKFYEGGGKAFNPLKLADNYVNVNEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCCC
TDLEDN
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8157629; 8144530 [H]