Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is adhA [H]

Identifier: 15674284

GI number: 15674284

Start: 60815

End: 61831

Strand: Direct

Name: adhA [H]

Synonym: SPy_0044

Alternate gene names: 15674284

Gene position: 60815-61831 (Clockwise)

Preceding gene: 15674283

Following gene: 15674285

Centisome position: 3.28

GC content: 42.28

Gene sequence:

>1017_bases
ATGAAAGCCGTAGTTGTTAATCAAGCTAGTACAGGTGTCGAAGTTGTTGAGCATGATCTTCCAAATATTGGTCATGGTGA
AGCGCTTGTTAAAGTAGAATACTGTGGCGTTTGTCATACTGATTTACACGTTGCACATGGCGATTTTGGTCAGGTACCAG
GACGTATTTTGGGGCACGAAGGTATTGGTATAGTAGAAGAAATTGGAGAAGGCGTAACATCCTTAAAGGTTGGTGATCGT
GTCTCTATTGCATGGTTCTTTGAAGGATGTGGTCATTGCGAATACTGTACTACAGGACGTGAGACACTTTGTCGTAGTGT
TAAAAATGCTGGATACAGTGTTGATGGAGGAATGAGTGAATATGCAGTAGTAACAGCTGATTATGCAGTTAAAGTTCCAG
AAGGTTTAGACCCGGCTCAAGCTTCTTCCATTACTTGTGCTGGTGTAACAACTTATAAAGCTATTAAAGAGGCAGGTGCT
GCTCCAGGCCAATGGATTGTTATCTTTGGGGCTGGTGGCCTTGGAAATCTGGCTGTTCAATACGCTAAAAAAGTCTTTAA
TGCACATGTTGTCGCAGTGGACATTAATAATGATAAACTTGAGTTAGCTAAAGAAGTTGGCGCAGATATTTTAGTTAACG
GCAAAGAAATTGAAGATGTTCCAGGCTATATTCAAGAAAAAACCGGTGGAGCACATGGTGTTGTGGTAACGGCTGTTTCT
AAAGTTGCTTTTAACCAAGCAATTGATAGTGTCCGTGCCGGTGGAACAGTTGTAGCCGTAGGTCTTCCATCAGAATACAT
GGAACTGTCTATCGTAAAAACTGTTTTAGATGGTATCAAAGTGGTCGGATCACTTGTAGGGACACGTAAAGACTTGGAAG
AAGCCTTTGCCTTTGGTGCAGAAGGTCTGGTTGCTCCGGTTGTCGAAAAAGTTCCAGTTGACACTGCTCCAGAAGTCTTT
GATGAAATGGAACGTGGTTTAATCCAAGGGCGCAAGGTCTTAGATTTCATCAGCTAA

Upstream 100 bases:

>100_bases
TTCAGAAACTTTTCAGGTTTCTATTGACTTTCATTGTGAAAAGATGTACAATTTATTTGTAACCGATTACAAAAAAGTCA
TTATTAGATGGAGGACTGAT

Downstream 100 bases:

>100_bases
ACATACAAATGTATTAAATATGAGATAAGCCTAAGTTGCTTAAACTTGATTCCAAATAAAATAGCACTCTCGAGTATCAG
AAAACATTTTTGACTCGAGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase I; ADH I [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MKAVVVNQASTGVEVVEHDLPNIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEEIGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADILVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVAPVVEKVPVDTAPEVF
DEMERGLIQGRKVLDFIS

Sequences:

>Translated_338_residues
MKAVVVNQASTGVEVVEHDLPNIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEEIGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADILVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVAPVVEKVPVDTAPEVF
DEMERGLIQGRKVLDFIS
>Mature_338_residues
MKAVVVNQASTGVEVVEHDLPNIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHEGIGIVEEIGEGVTSLKVGDR
VSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSEYAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGA
APGQWIVIFGAGGLGNLAVQYAKKVFNAHVVAVDINNDKLELAKEVGADILVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGAEGLVAPVVEKVPVDTAPEVF
DEMERGLIQGRKVLDFIS

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=342, Percent_Identity=30.4093567251462, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI4501933, Length=348, Percent_Identity=29.8850574712644, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4501929, Length=338, Percent_Identity=29.2899408284024, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI71743840, Length=295, Percent_Identity=29.4915254237288, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI262073058, Length=295, Percent_Identity=29.4915254237288, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI71565154, Length=250, Percent_Identity=33.6, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI156627571, Length=334, Percent_Identity=26.3473053892216, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI71565152, Length=345, Percent_Identity=26.9565217391304, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI156523966, Length=224, Percent_Identity=31.6964285714286, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501939, Length=224, Percent_Identity=31.6964285714286, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=65.4761904761905, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=29.9120234604106, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787863, Length=298, Percent_Identity=31.8791946308725, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1786518, Length=347, Percent_Identity=27.0893371757925, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788073, Length=265, Percent_Identity=31.3207547169811, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI226510992, Length=339, Percent_Identity=28.3185840707965, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87082401, Length=342, Percent_Identity=26.6081871345029, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1788075, Length=344, Percent_Identity=27.906976744186, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790718, Length=310, Percent_Identity=29.3548387096774, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1786552, Length=246, Percent_Identity=33.739837398374, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082125, Length=266, Percent_Identity=27.4436090225564, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788407, Length=297, Percent_Identity=28.2828282828283, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=358, Percent_Identity=26.536312849162, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17562582, Length=340, Percent_Identity=38.5294117647059, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17562584, Length=339, Percent_Identity=37.7581120943953, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71988145, Length=340, Percent_Identity=37.3529411764706, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17562876, Length=264, Percent_Identity=32.9545454545455, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562878, Length=271, Percent_Identity=32.1033210332103, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=266, Percent_Identity=29.3233082706767, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=285, Percent_Identity=27.3684210526316, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=263, Percent_Identity=27.3764258555133, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324486, Length=340, Percent_Identity=40.2941176470588, Blast_Score=235, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6323961, Length=341, Percent_Identity=39.5894428152493, Blast_Score=232, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6319621, Length=341, Percent_Identity=39.2961876832845, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6323729, Length=322, Percent_Identity=40.3726708074534, Blast_Score=228, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6319949, Length=335, Percent_Identity=29.2537313432836, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=28.2131661442006, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320033, Length=230, Percent_Identity=36.0869565217391, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6322619, Length=305, Percent_Identity=28.8524590163934, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319955, Length=305, Percent_Identity=28.5245901639344, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323099, Length=271, Percent_Identity=31.3653136531365, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=289, Percent_Identity=24.2214532871972, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137530, Length=222, Percent_Identity=30.6306306306306, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17737895, Length=342, Percent_Identity=28.3625730994152, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17737897, Length=322, Percent_Identity=27.639751552795, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221457811, Length=159, Percent_Identity=28.9308176100629, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551930, Length=159, Percent_Identity=28.9308176100629, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550770, Length=159, Percent_Identity=28.9308176100629, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 35367; Mature: 35367

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVVNQASTGVEVVEHDLPNIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHE
CCEEEEECCCCCHHHHHHCCCCCCCCCEEEEEEECCEECCCCEEECCCCCCCCCEEECCC
GIGIVEEIGEGVTSLKVGDRVSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSE
CCCHHHHHCCCHHEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
YAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGAAPGQWIVIFGAGGLGNLAVQ
EEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVVAVDINNDKLELAKEVGADILVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
HHHHHHCCEEEEEECCCCHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHH
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGA
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EGLVAPVVEKVPVDTAPEVFDEMERGLIQGRKVLDFIS
CCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MKAVVVNQASTGVEVVEHDLPNIGHGEALVKVEYCGVCHTDLHVAHGDFGQVPGRILGHE
CCEEEEECCCCCHHHHHHCCCCCCCCCEEEEEEECCEECCCCEEECCCCCCCCCEEECCC
GIGIVEEIGEGVTSLKVGDRVSIAWFFEGCGHCEYCTTGRETLCRSVKNAGYSVDGGMSE
CCCHHHHHCCCHHEEECCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
YAVVTADYAVKVPEGLDPAQASSITCAGVTTYKAIKEAGAAPGQWIVIFGAGGLGNLAVQ
EEEEEECEEEECCCCCCCCCCCCEEEECHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHH
YAKKVFNAHVVAVDINNDKLELAKEVGADILVNGKEIEDVPGYIQEKTGGAHGVVVTAVS
HHHHHHCCEEEEEECCCCHHHHHHHCCCEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHH
KVAFNQAIDSVRAGGTVVAVGLPSEYMELSIVKTVLDGIKVVGSLVGTRKDLEEAFAFGA
HHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EGLVAPVVEKVPVDTAPEVFDEMERGLIQGRKVLDFIS
CCHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2185223; 8320209; 2935393 [H]