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The map label for this gene is purK [H]

Identifier: 15674276

GI number: 15674276

Start: 48485

End: 49594

Strand: Direct

Name: purK [H]

Synonym: SPy_0034

Alternate gene names: 15674276

Gene position: 48485-49594 (Clockwise)

Preceding gene: 15674275

Following gene: 15674277

Centisome position: 2.62

GC content: 49.73

Gene sequence:

>1110_bases
ATGAGGAACAAGGAAAAATCGCAGAGGAGTCAAGTGGTGAACTCATTTAAGACCATTGGGATTATCGGTGGTGGTCAGCT
GGGGCAGATGATGGCCATTGCGGCTATCTATATGGGTCACAAGGTCATCACGCTGGATCCTGCTAGCGACAGCCCTGCCT
CCCGCGTTAGCGAGGTAATTGTGGCGCCTTACGATGATGTTGAGGCTTTGGGACAATTGGCTGCGCGTTGCGATGTGTTG
ACTTATGAGTTTGAGAATGTTGATGCGGACGGTTTGGATGCCGTTGTGTCAGCTTGTCAGCTACCGCAGGGGACCGATCT
GCTCCGCATTTCCCAAAACCGTATCGTTGAAAAAGACTTTCTGGCAAATAAGGCTGGTGTGACAGTCGCTCCCTATAAGG
TGGTGACGTCTAGCCTTGACCTAGGGGGGCTTGATTTGACCAAGACCTATGTCCTCAAGACAGAGACAGGTGGTTATGAC
GGTCATGGGCAAAAGATTATCCGCTCAGCAGAAGATTTGCCAGAGGCGCAGCAATTAGCTAACTCAGCTCAGTGTGTCTT
GGAAGAGTTTGTCAACTTTGACCTTGAAATCTCAGTCATCGTGTCTGGAAATGGCAAGGATGTGACGGTCTTTCCCGTTC
AGGAAAATATCCACCGCAACAATATCCTGTCAAAAACCATCGTACCAGCTCGCATCTCAGATCAACTGGCTGATAAGGCT
AAGAAAACGGCGGTGCAGATTGCCAAGAAACTCCAGCTGTCAGGAACTCTCTGTGTGGAAATGTTTACGACCGCAGATGA
TATCATTGTCAATGAAATTGCCCCACGCCCCCACAACTCAGGGCGCTATTCTATCGAAGCCTGCGACTTTTCACAGTTTG
ACACCCACATCTTGGGTGTGTTGGGCGCACCACTTCCTCAGATTCAGCTCCACGCCCCAGCCGTCATGCTCAATGTCCTA
GGACAACATGTCCAGCAGGCAACTGACTATGTTGCCAAAAACCCTAGCGCCCACCTCCACATGTATGGTAAACTAGAAGC
GAAACATAACCGCAAAATGGGACATGTGACGGTGTTTGCAAAAGATGCGGATGAGGTGAAGGAGTTTTAA

Upstream 100 bases:

>100_bases
ATGGCTATCGGAGAAGCGGGAGCGACTAACGCTGCCCTGACAGCCCTCCGTATCCTCTCTATCGAGGACCAAAATCTGGC
TGATGCGCTAGCTCATTTCC

Downstream 100 bases:

>100_bases
AGAGTTAATTAGGAGATGTTTATTTTATGGCAAATATTCAAATAAATAGAATAAAAAGTAAATTGACAGAACTGTTTAGT
AGTATTATCTATATGGGTAA

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MRNKEKSQRSQVVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALGQLAARCDVL
TYEFENVDADGLDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYD
GHGQKIIRSAEDLPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKA
KKTAVQIAKKLQLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLHAPAVMLNVL
GQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF

Sequences:

>Translated_369_residues
MRNKEKSQRSQVVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALGQLAARCDVL
TYEFENVDADGLDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYD
GHGQKIIRSAEDLPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKA
KKTAVQIAKKLQLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLHAPAVMLNVL
GQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF
>Mature_369_residues
MRNKEKSQRSQVVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVIVAPYDDVEALGQLAARCDVL
TYEFENVDADGLDAVVSACQLPQGTDLLRISQNRIVEKDFLANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYD
GHGQKIIRSAEDLPEAQQLANSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKA
KKTAVQIAKKLQLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGVLGAPLPQIQLHAPAVMLNVL
GQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFAKDADEVKEF

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=356, Percent_Identity=27.8089887640449, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1788155, Length=362, Percent_Identity=24.0331491712707, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324702, Length=376, Percent_Identity=34.0425531914894, Blast_Score=193, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR006140
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C; PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40064; Mature: 40064

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKEKSQRSQVVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVI
CCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHEE
VAPYDDVEALGQLAARCDVLTYEFENVDADGLDAVVSACQLPQGTDLLRISQNRIVEKDF
ECCCCCHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
LANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYDGHGQKIIRSAEDLPEAQQLA
HCCCCCCEECCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHH
NSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKA
HHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECHHCCCHHCCHHHCCCCHHHHHHHHHHH
KKTAVQIAKKLQLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGV
HHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHH
LGAPLPQIQLHAPAVMLNVLGQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFA
HCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEE
KDADEVKEF
CCHHHHHCC
>Mature Secondary Structure
MRNKEKSQRSQVVNSFKTIGIIGGGQLGQMMAIAAIYMGHKVITLDPASDSPASRVSEVI
CCCHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHEE
VAPYDDVEALGQLAARCDVLTYEFENVDADGLDAVVSACQLPQGTDLLRISQNRIVEKDF
ECCCCCHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHHH
LANKAGVTVAPYKVVTSSLDLGGLDLTKTYVLKTETGGYDGHGQKIIRSAEDLPEAQQLA
HCCCCCCEECCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHCCCHHHHHH
NSAQCVLEEFVNFDLEISVIVSGNGKDVTVFPVQENIHRNNILSKTIVPARISDQLADKA
HHHHHHHHHHHCCCEEEEEEEECCCCEEEEEECHHCCCHHCCHHHCCCCHHHHHHHHHHH
KKTAVQIAKKLQLSGTLCVEMFTTADDIIVNEIAPRPHNSGRYSIEACDFSQFDTHILGV
HHHHHHHHHHHHCCCEEEEEEHHCCCHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHH
LGAPLPQIQLHAPAVMLNVLGQHVQQATDYVAKNPSAHLHMYGKLEAKHNRKMGHVTVFA
HCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCEEEEEE
KDADEVKEF
CCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA