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The map label for this gene is purC [H]

Identifier: 15674268

GI number: 15674268

Start: 35364

End: 36098

Strand: Direct

Name: purC [H]

Synonym: SPy_0024

Alternate gene names: 15674268

Gene position: 35364-36098 (Clockwise)

Preceding gene: 15674267

Following gene: 15674269

Centisome position: 1.91

GC content: 35.92

Gene sequence:

>735_bases
ATGAAAACAGAAAGAAAGGCGAATAATCAAGTGACTAACCAGCTTATTTATAAAGGAAAAGCGAAAGATATTTATAGTAC
AAAAGATGAAAATGTGATTAGAACGGTCTATAAAGACCAAGCTACTATGTTGAATGGAGCTCGTAAGGAGACTATTGATG
GCAAGGGAGCACTAAATAATCAGATTTCATCTCTTATTTTTGAGAAATTAAATAAGGCTGGTGTGGTGACACATTATATT
GAGCAAATTTCAAAAAACGAACAATTGAATAAAAAAGTTGATATTATTCCACTTGAGGTGGTGTTACGGAATGTGACAGC
AGGCTCATTTTCAAAACGTTTTGGAGTGGAAGAAGGACATGTTCTTGAAACGCCAATTGTGGAATTTTACTACAAAAATG
ATGATCTGGATGATCCTTTTATCAATGATGAGCATGTGAAGTTTTTGGGTATTGTTAATGATGAGGAGATTGCTTATCTG
AAAGGAGAGACTCGCCGTATTAATGAACTCTTGAAAGGTTGGTTTGCTCAGATTGGGCTTAACTTGATTGACTTCAAGTT
GGAGTTCGGATTTGATCAAGAAGGTACAATTATCTTAGCAGATGAATTTTCGCCTGATAACTGTCGCCTATGGGATAAGA
ATGGTAACCATATGGACAAGGATGTTTTTAGAAGAGACCTTGGCAACCTGACGGATGTCTATCAAGTTGTACTTGAGAAG
TTGATAGCATTGTAA

Upstream 100 bases:

>100_bases
TAAGCTCTTTTTATTATTCTTTAAAAACGAACCTTTTTTTAAAAAAACTTATAAACGTAAATAATATCTTGAATATTTTT
ATAGAGTATGTTACTCTTAA

Downstream 100 bases:

>100_bases
CTAGAAGAGGAAGGAATTGAATCCGTTCGGGAAACTCCGAAAAAAAGATGGAACTTACTGAAATCTCAATTTCAGATGTC
CTCCTATTTTCCAGTCGCTC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MKTERKANNQVTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVVTHYI
EQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGHVLETPIVEFYYKNDDLDDPFINDEHVKFLGIVNDEEIAYL
KGETRRINELLKGWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEK
LIAL

Sequences:

>Translated_244_residues
MKTERKANNQVTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVVTHYI
EQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGHVLETPIVEFYYKNDDLDDPFINDEHVKFLGIVNDEEIAYL
KGETRRINELLKGWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEK
LIAL
>Mature_244_residues
MKTERKANNQVTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNNQISSLIFEKLNKAGVVTHYI
EQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGHVLETPIVEFYYKNDDLDDPFINDEHVKFLGIVNDEEIAYL
KGETRRINELLKGWFAQIGLNLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEK
LIAL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=227, Percent_Identity=34.8017621145374, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI5453539, Length=227, Percent_Identity=34.8017621145374, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI119220559, Length=234, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=42.2907488986784, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=232, Percent_Identity=37.0689655172414, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18860083, Length=228, Percent_Identity=30.7017543859649, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24583917, Length=248, Percent_Identity=28.2258064516129, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28006; Mature: 28006

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTERKANNQVTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNN
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCHHH
QISSLIFEKLNKAGVVTHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGH
HHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCCCCEEHHHHHHHHCCCCCHHHHCCCCCCC
VLETPIVEFYYKNDDLDDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKGWFAQIGL
EECCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCC
NLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEK
EEEEEEEEECCCCCCEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHH
LIAL
HHCC
>Mature Secondary Structure
MKTERKANNQVTNQLIYKGKAKDIYSTKDENVIRTVYKDQATMLNGARKETIDGKGALNN
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCHHH
QISSLIFEKLNKAGVVTHYIEQISKNEQLNKKVDIIPLEVVLRNVTAGSFSKRFGVEEGH
HHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCCCCEEHHHHHHHHCCCCCHHHHCCCCCCC
VLETPIVEFYYKNDDLDDPFINDEHVKFLGIVNDEEIAYLKGETRRINELLKGWFAQIGL
EECCCCEEEEECCCCCCCCCCCCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHCC
NLIDFKLEFGFDQEGTIILADEFSPDNCRLWDKNGNHMDKDVFRRDLGNLTDVYQVVLEK
EEEEEEEEECCCCCCEEEEEECCCCCCCEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHH
LIAL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA