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The map label for this gene is pepC

Identifier: 15673860

GI number: 15673860

Start: 1947325

End: 1948635

Strand: Reverse

Name: pepC

Synonym: L130687

Alternate gene names: 15673860

Gene position: 1948635-1947325 (Counterclockwise)

Preceding gene: 15673861

Following gene: 15673859

Centisome position: 82.37

GC content: 36.38

Gene sequence:

>1311_bases
ATGACAGTAACATCAGATTTCACACAAAAACTCTACGAAAATTTTGCAGAAAATACAAAATTGCGTGCGGTGGAAAATGC
CGTGACTAAAAATGGTTTGCTTTCATCACTCGAAGTCCGTGGTTCACATGCAGCAAATTTGCCTGAGTTTTCAATTGACT
TGACAAAAGACCCTGTAACGAATCAAAAACAATCTGGTCGTTGCTGGATGTTTGCTGCTTTGAACACTTTCCGTCATAAA
TTTATCAATGAATTTAAAACAGAGGATTTTGAGTTTTCACAAGCTTACACTTTCTTCTGGGATAAATATGAAAAATCAAA
CTGGTTCATGGAACAAATTATTGGTGATATTGAAATGGACGATCGTCGTTTGAAATTCCTTTTACAAACACCACAACAAG
ATGGCGGCCAATGGGATATGATGGTTGCAATTTTTGAAAAATATGGAATTGTTCCCAAAGCTGTTTATCCTGAATCACAA
GCTTCAAGTAGCTCACGTGAATTGAATCAATACTTGAATAAACTACTCCGTCAAGATGCTGAAATTTTGCGTTATACAAT
TGAGCAAGGTGGAGATGTTGAAGCAGTTAAAGAAGAACTTTTGCAAGAAGTCTTTAATTTCCTTGCGGTAACTTTAGGTT
TGCCACCACAAAATTTTGAATTTGCTTTCCGTAATAAAGATAATGAATACAAAAAATTTGTTGGTAGTCCAAAAGAATTT
TACAATGAATATGTTGGAATTGATTTGAATAATTATGTGTCAGTAATCAATGCTCCAACTGCTGACAAACCTTATAATAA
GAGCTACACAGTTGAGTTTCTTGGAAATGTTGTCGGTGGTAAAGAAGTGAAACATTTGAATGTTGAAATGGACCGCTTTA
AAAAATTGGCCATTGCCCAAATGCAAGCTGGTGAAACAGTTTGGTTTGGTTGTGACGTGGGTCAAGAATCAAATCGTTCA
GCAGGACTTTTGACAATGGATTCTTATGATTTCAAATCTTCATTGGATATTGAATTTACTCAAAGCAAAGCAGGACGTCT
TGACTATGGTGAGTCGTTGATGACGCATGCCATGGTTTTAGCGGGTGTTGATTTAGATGCTGACGGAAATTCAACTAAAT
GGAAAGTTGAAAATTCATGGGGTAAAGATGCGGGTCAAAAAGGATATTTTGTTGCCTCTGATGAATGGATGGATGAATAT
ACTTATCAAATTGTTGTCCGTAAAGACCTTTTAACTGAAGAAGAATTGGCTGCTTACGAAGAGAAACCTCAAGTACTTCT
ACCATGGGACCCAATGGGTGCTTTAGCTTAA

Upstream 100 bases:

>100_bases
TAGAAGAATGTAAAAAATAATAGAATATCATTATTCAAAATTGATAATGATTATTTTTATCGAAACTTTTGTCAGAAGTT
TCGATTTATTGGGAGGTATT

Downstream 100 bases:

>100_bases
TTTGCAAACAAAGAACATTTAACTTTAGGTTAAATGTTTTTTTATTGACTTAAAGTTCACTTCAAGTGTTAAAATAAAAG
AATGAATATAAAAAAAGCTG

Product: aminopeptidase C

Products: NA

Alternate protein names: Bleomycin hydrolase

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSIDLTKDPVTNQKQSGRCWMFAALNTFRHK
FINEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDIEMDDRRLKFLLQTPQQDGGQWDMMVAIFEKYGIVPKAVYPESQ
ASSSSRELNQYLNKLLRQDAEILRYTIEQGGDVEAVKEELLQEVFNFLAVTLGLPPQNFEFAFRNKDNEYKKFVGSPKEF
YNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQMQAGETVWFGCDVGQESNRS
AGLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGKDAGQKGYFVASDEWMDEY
TYQIVVRKDLLTEEELAAYEEKPQVLLPWDPMGALA

Sequences:

>Translated_436_residues
MTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSIDLTKDPVTNQKQSGRCWMFAALNTFRHK
FINEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDIEMDDRRLKFLLQTPQQDGGQWDMMVAIFEKYGIVPKAVYPESQ
ASSSSRELNQYLNKLLRQDAEILRYTIEQGGDVEAVKEELLQEVFNFLAVTLGLPPQNFEFAFRNKDNEYKKFVGSPKEF
YNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQMQAGETVWFGCDVGQESNRS
AGLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGKDAGQKGYFVASDEWMDEY
TYQIVVRKDLLTEEELAAYEEKPQVLLPWDPMGALA
>Mature_435_residues
TVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSIDLTKDPVTNQKQSGRCWMFAALNTFRHKF
INEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDIEMDDRRLKFLLQTPQQDGGQWDMMVAIFEKYGIVPKAVYPESQA
SSSSRELNQYLNKLLRQDAEILRYTIEQGGDVEAVKEELLQEVFNFLAVTLGLPPQNFEFAFRNKDNEYKKFVGSPKEFY
NEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQMQAGETVWFGCDVGQESNRSA
GLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVLAGVDLDADGNSTKWKVENSWGKDAGQKGYFVASDEWMDEYT
YQIVVRKDLLTEEELAAYEEKPQVLLPWDPMGALA

Specific function: Hydrolyzes naphthylamide-substituted amino acids as well as di- and tripeptides in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin and vasopressin. Has also a bleomycin hydrolase activity

COG id: COG3579

COG function: function code E; Aminopeptidase C

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C1 family

Homologues:

Organism=Homo sapiens, GI4557367, Length=450, Percent_Identity=39.7777777777778, Blast_Score=356, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6324090, Length=394, Percent_Identity=37.0558375634518, Blast_Score=283, Evalue=3e-77,
Organism=Drosophila melanogaster, GI161077632, Length=453, Percent_Identity=36.8653421633554, Blast_Score=314, Evalue=8e-86,
Organism=Drosophila melanogaster, GI24640588, Length=453, Percent_Identity=36.8653421633554, Blast_Score=314, Evalue=9e-86,
Organism=Drosophila melanogaster, GI161077630, Length=368, Percent_Identity=38.3152173913043, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI20130175, Length=385, Percent_Identity=28.5714285714286, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PEPC_LACLA (Q9CEG3)

Other databases:

- EMBL:   AE005176
- PIR:   F86859
- RefSeq:   NP_268035.1
- ProteinModelPortal:   Q9CEG3
- SMR:   Q9CEG3
- GeneID:   1115543
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L130687
- NMPDR:   fig|272623.1.peg.1924
- HOGENOM:   HBG350935
- OMA:   LSQNYTN
- ProtClustDB:   CLSK876938
- BioCyc:   LLAC272623:L130687-MONOMER
- BRENDA:   3.4.22.40
- GO:   GO:0006508
- InterPro:   IPR000169
- InterPro:   IPR004134
- PANTHER:   PTHR10363
- PIRSF:   PIRSF005700

Pfam domain/function: PF03051 Peptidase_C1_2

EC number: =3.4.22.40

Molecular weight: Translated: 49914; Mature: 49783

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS00640 THIOL_PROTEASE_ASN; PS00139 THIOL_PROTEASE_CYS; PS00639 THIOL_PROTEASE_HIS

Important sites: ACT_SITE 68-68 ACT_SITE 356-356 ACT_SITE 378-378

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSIDLTKDPVT
CCCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCEEEECCCCCC
NQKQSGRCWMFAALNTFRHKFINEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDIEMD
CCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
DRRLKFLLQTPQQDGGQWDMMVAIFEKYGIVPKAVYPESQASSSSRELNQYLNKLLRQDA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EILRYTIEQGGDVEAVKEELLQEVFNFLAVTLGLPPQNFEFAFRNKDNEYKKFVGSPKEF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHCCCHHHH
YNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQ
HHHHCCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHH
MQAGETVWFGCDVGQESNRSAGLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVL
HCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
AGVDLDADGNSTKWKVENSWGKDAGQKGYFVASDEWMDEYTYQIVVRKDLLTEEELAAYE
HCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECHHHHHCCEEEEEEEHHHCCHHHHHHHH
EKPQVLLPWDPMGALA
CCCCEEECCCCCCCCC
>Mature Secondary Structure 
TVTSDFTQKLYENFAENTKLRAVENAVTKNGLLSSLEVRGSHAANLPEFSIDLTKDPVT
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHEECCCCCCCCCCCEEEECCCCCC
NQKQSGRCWMFAALNTFRHKFINEFKTEDFEFSQAYTFFWDKYEKSNWFMEQIIGDIEMD
CCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
DRRLKFLLQTPQQDGGQWDMMVAIFEKYGIVPKAVYPESQASSSSRELNQYLNKLLRQDA
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
EILRYTIEQGGDVEAVKEELLQEVFNFLAVTLGLPPQNFEFAFRNKDNEYKKFVGSPKEF
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHCCCHHHH
YNEYVGIDLNNYVSVINAPTADKPYNKSYTVEFLGNVVGGKEVKHLNVEMDRFKKLAIAQ
HHHHCCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHH
MQAGETVWFGCDVGQESNRSAGLLTMDSYDFKSSLDIEFTQSKAGRLDYGESLMTHAMVL
HCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
AGVDLDADGNSTKWKVENSWGKDAGQKGYFVASDEWMDEYTYQIVVRKDLLTEEELAAYE
HCCCCCCCCCCCEEEEECCCCCCCCCCCEEEECHHHHHCCEEEEEEEHHHCCHHHHHHHH
EKPQVLLPWDPMGALA
CCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471