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The map label for this gene is pheA

Identifier: 15673724

GI number: 15673724

Start: 1800161

End: 1801000

Strand: Reverse

Name: pheA

Synonym: L0055

Alternate gene names: 15673724

Gene position: 1801000-1800161 (Counterclockwise)

Preceding gene: 15673725

Following gene: 15673723

Centisome position: 76.13

GC content: 35.24

Gene sequence:

>840_bases
ATGAAAATTGCGTATTTAGGACCTCGTGGCTCTTTTTGTTCGGTGGTGGCTGAGACAGCATTTGTATCAGAAGAATTATT
TGCTTATGATAGTATTCTGGATGTTATTGAAGCTTATGATGAAGGAAAATGTGATTTTGCTCTTGTTCCTATTGAAAATT
CGACTGAAGGAACTGTGAATATGAGTATTGATAAAATTTTTCATGATTCTAAGGCGACAGTTGTGGCTGAATTTGTTTTG
CCAATTTCACAAAATTTGCTGGCTCTTTCAAAAGAGGGGAAAATTGAACATATTTATTCCCACCCTCAAGCGCTTGCACA
AACACGAAATTATTTACGAGAGCATTATCCACAGGCAAAGGTTGAAATTACTGATTCTACTTCAGCAGCAGCTGAATTTG
TGAAAAATCATCCAGATTTGCCAATTGCAGCTGTTGCTAATTCTTACGCGGCTAAAATGTATGATTTAGAGATTGTTGCC
AAAAATATTCAGGATTTAGCAGGAAATTCTACTCGGTTTTGGTTATTGGGAAAAGAGAAAAAATCATTTGATTTACTAAA
AACAGGTGAGAAGGTGAGTTTGGCTTTGACTCTACCTGATAACCTGCCAGGAGCGCTTCATAAAGCGATTTCTGTTTTTG
CTTGGCGTGATATTGATATGACAAAAATTGAATCACGTCCTTTAAGAACAAGGCTAGGTCAGTACTTTTTTAATATTGAT
TTAGTAAATAATGAAAAAAATAATTTAAAAATTCCTTATGCTCTTGAAGAACTATCAGGTTTGGGAGTAAAGGTTCGTTT
ATTAGGAAATTATGCAGTCTATTCATTGGGAGAGGGGTAA

Upstream 100 bases:

>100_bases
AATGACTATGCAAAAGTGGCCGATTTAACGATTGATGTTACTGATAAGAGTCCTGAGCAAATTGTAGAAGAGATTCGTGA
AAAATGGGGGATAAATTAAG

Downstream 100 bases:

>100_bases
AGGTGAGAATTTATTTTGTACGACATGGTAAGACGGAGTGGAACTTGGCGCGACGTTTGCAAGGACAAAAAGGAGATTCA
CCTTTATTGCCAGAATCTTA

Product: prephenate dehydratase

Products: NA

Alternate protein names: PDT

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MKIAYLGPRGSFCSVVAETAFVSEELFAYDSILDVIEAYDEGKCDFALVPIENSTEGTVNMSIDKIFHDSKATVVAEFVL
PISQNLLALSKEGKIEHIYSHPQALAQTRNYLREHYPQAKVEITDSTSAAAEFVKNHPDLPIAAVANSYAAKMYDLEIVA
KNIQDLAGNSTRFWLLGKEKKSFDLLKTGEKVSLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFNID
LVNNEKNNLKIPYALEELSGLGVKVRLLGNYAVYSLGEG

Sequences:

>Translated_279_residues
MKIAYLGPRGSFCSVVAETAFVSEELFAYDSILDVIEAYDEGKCDFALVPIENSTEGTVNMSIDKIFHDSKATVVAEFVL
PISQNLLALSKEGKIEHIYSHPQALAQTRNYLREHYPQAKVEITDSTSAAAEFVKNHPDLPIAAVANSYAAKMYDLEIVA
KNIQDLAGNSTRFWLLGKEKKSFDLLKTGEKVSLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFNID
LVNNEKNNLKIPYALEELSGLGVKVRLLGNYAVYSLGEG
>Mature_279_residues
MKIAYLGPRGSFCSVVAETAFVSEELFAYDSILDVIEAYDEGKCDFALVPIENSTEGTVNMSIDKIFHDSKATVVAEFVL
PISQNLLALSKEGKIEHIYSHPQALAQTRNYLREHYPQAKVEITDSTSAAAEFVKNHPDLPIAAVANSYAAKMYDLEIVA
KNIQDLAGNSTRFWLLGKEKKSFDLLKTGEKVSLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFNID
LVNNEKNNLKIPYALEELSGLGVKVRLLGNYAVYSLGEG

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain

Homologues:

Organism=Escherichia coli, GI1788951, Length=288, Percent_Identity=29.1666666666667, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324013, Length=304, Percent_Identity=24.6710526315789, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHEA_LACLA (Q9CEU2)

Other databases:

- EMBL:   AE005176
- PIR:   F86842
- RefSeq:   NP_267898.1
- ProteinModelPortal:   Q9CEU2
- SMR:   Q9CEU2
- GeneID:   1115405
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0055
- NMPDR:   fig|272623.1.peg.1786
- HOGENOM:   HBG693866
- OMA:   CRKWLDA
- ProtClustDB:   PRK11898
- BioCyc:   LLAC272623:L0055-MONOMER
- BRENDA:   4.2.1.51
- InterPro:   IPR001086
- InterPro:   IPR018528

Pfam domain/function: PF00800 PDT

EC number: =4.2.1.51

Molecular weight: Translated: 30967; Mature: 30967

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00857 PREPHENATE_DEHYDR_1; PS00858 PREPHENATE_DEHYDR_2; PS51171 PREPHENATE_DEHYDR_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAYLGPRGSFCSVVAETAFVSEELFAYDSILDVIEAYDEGKCDFALVPIENSTEGTVN
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEE
MSIDKIFHDSKATVVAEFVLPISQNLLALSKEGKIEHIYSHPQALAQTRNYLREHYPQAK
EEHHHHHCCCCHHEEHHHHHHHCCCCEEECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCE
VEITDSTSAAAEFVKNHPDLPIAAVANSYAAKMYDLEIVAKNIQDLAGNSTRFWLLGKEK
EEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
KSFDLLKTGEKVSLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFNID
CCCHHHCCCCEEEEEEECCCCCCHHHHHHHHHHEECCCCHHHCCCCCHHHHHCCEEEEEE
LVNNEKNNLKIPYALEELSGLGVKVRLLGNYAVYSLGEG
EEECCCCCEECCEEHHHHHCCCEEEEEEECEEEEEECCC
>Mature Secondary Structure
MKIAYLGPRGSFCSVVAETAFVSEELFAYDSILDVIEAYDEGKCDFALVPIENSTEGTVN
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEE
MSIDKIFHDSKATVVAEFVLPISQNLLALSKEGKIEHIYSHPQALAQTRNYLREHYPQAK
EEHHHHHCCCCHHEEHHHHHHHCCCCEEECCCCCCHHHHCCHHHHHHHHHHHHHHCCCCE
VEITDSTSAAAEFVKNHPDLPIAAVANSYAAKMYDLEIVAKNIQDLAGNSTRFWLLGKEK
EEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
KSFDLLKTGEKVSLALTLPDNLPGALHKAISVFAWRDIDMTKIESRPLRTRLGQYFFNID
CCCHHHCCCCEEEEEEECCCCCCHHHHHHHHHHEECCCCHHHCCCCCHHHHHCCEEEEEE
LVNNEKNNLKIPYALEELSGLGVKVRLLGNYAVYSLGEG
EEECCCCCEECCEEHHHHHCCCEEEEEEECEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471