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The map label for this gene is trxA

Identifier: 15673626

GI number: 15673626

Start: 1691321

End: 1691635

Strand: Reverse

Name: trxA

Synonym: L0195

Alternate gene names: 15673626

Gene position: 1691635-1691321 (Counterclockwise)

Preceding gene: 15673627

Following gene: 15673625

Centisome position: 71.51

GC content: 36.83

Gene sequence:

>315_bases
ATGGAATATAATATTACTGATGCAACGTTTGATGAAGAAACAAAAGAAGGGCTTGTTTTAATTGACTTTTGGGCAACTTG
GTGTGGTCCATGTCGCATGCAAGCGCCAATTTTGGAACAACTTTCAGAAGAACTTGACGAATCAGAACTTAAGATTTGCA
AAATGGATGTTGATGAAAACCCAGCAACAGCCCAAGGATTTGGCATTATGTCTATCCCAACATTGATGTTCAAAAAAGAT
GGTGAAGAAGTAAAACGCATTGTTGGTGTTCAAACAAAAGCACAACTTAAAGCCGTTATTGCTGAATTATCATAA

Upstream 100 bases:

>100_bases
GTAAAATAATAAATTTCTCAAAATCTATTTTCTTGAAATTTTAAGTGAATTACACTAGAATAGTCTTACTGAAGAAAATT
ATTTCAATGAAGGAGATAAA

Downstream 100 bases:

>100_bases
TAAAAATTACTGACAGAACTTTTTTCTTCTTGAAATAAAGTCTGTCAGTATTTTTTTATATTCAATTCTAGTGAAAAGTT
CTGTCAGTAAAAGAGAGTGA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 104; Mature: 104

Protein sequence:

>104_residues
MEYNITDATFDEETKEGLVLIDFWATWCGPCRMQAPILEQLSEELDESELKICKMDVDENPATAQGFGIMSIPTLMFKKD
GEEVKRIVGVQTKAQLKAVIAELS

Sequences:

>Translated_104_residues
MEYNITDATFDEETKEGLVLIDFWATWCGPCRMQAPILEQLSEELDESELKICKMDVDENPATAQGFGIMSIPTLMFKKD
GEEVKRIVGVQTKAQLKAVIAELS
>Mature_104_residues
MEYNITDATFDEETKEGLVLIDFWATWCGPCRMQAPILEQLSEELDESELKICKMDVDENPATAQGFGIMSIPTLMFKKD
GEEVKRIVGVQTKAQLKAVIAELS

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=104, Percent_Identity=30.7692307692308, Blast_Score=63, Evalue=6e-11,
Organism=Escherichia coli, GI87082331, Length=96, Percent_Identity=44.7916666666667, Blast_Score=97, Evalue=1e-22,
Organism=Escherichia coli, GI1788936, Length=100, Percent_Identity=39, Blast_Score=72, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71980562, Length=74, Percent_Identity=33.7837837837838, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=74, Percent_Identity=33.7837837837838, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=96, Percent_Identity=41.6666666666667, Blast_Score=82, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=98, Percent_Identity=39.7959183673469, Blast_Score=80, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319925, Length=81, Percent_Identity=37.037037037037, Blast_Score=66, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=42.1052631578947, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=42.1052631578947, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=33.6734693877551, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=79, Percent_Identity=35.4430379746835, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21358065, Length=94, Percent_Identity=35.1063829787234, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11673; Mature: 11673

Theoretical pI: Translated: 4.05; Mature: 4.05

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYNITDATFDEETKEGLVLIDFWATWCGPCRMQAPILEQLSEELDESELKICKMDVDEN
CCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCHHHHEEEEECCCCC
PATAQGFGIMSIPTLMFKKDGEEVKRIVGVQTKAQLKAVIAELS
CCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MEYNITDATFDEETKEGLVLIDFWATWCGPCRMQAPILEQLSEELDESELKICKMDVDEN
CCCCCCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCHHHHHHHHHCCHHHHEEEEECCCCC
PATAQGFGIMSIPTLMFKKDGEEVKRIVGVQTKAQLKAVIAELS
CCCCCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]