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The map label for this gene is kinA

Identifier: 15673575

GI number: 15673575

Start: 1637285

End: 1638760

Strand: Reverse

Name: kinA

Synonym: L0130

Alternate gene names: 15673575

Gene position: 1638760-1637285 (Counterclockwise)

Preceding gene: 15673576

Following gene: 15673574

Centisome position: 69.27

GC content: 34.55

Gene sequence:

>1476_bases
ATGAAAAAACTATTTACTTTCAATAAGAAAAAAGAGACGGTAGAGGAAAGTTCGGCTAAGCGGTCTATCATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTTTGTTTGCTACTTTGACTTATCAATTGACAATCAGTTCTT
TTATTAAAGAAGAACAACAATTATTAACTCGCTCTATGGATAGTGTTGAGGAAGTCTTAGAAAAAGCAGATGCTCCTTTG
AATTCATCGAATTTGAACACATATATTGAAGCGACATCAAAGATTCAAAATGGTGAGTCTGAAGGAATGAGTTTGGGTAG
TATCATTGGGACACGGAAAGCATTTTATATTTATGACTTAAATCATAAATTATTGTATTCAACGAATCGACATACTTTTG
GTTTTCAGAATCAGGCTAATAATGAAATGAAAGAGATTCGGGGAGAAAATCCAGGTTATTTAGTTCAGAGAAAAATTATT
TCTAAGTCAACAGGACAAGTTGTGGGATACTTACAGGCTTTTTATGATACGACGACTTATCATCGAATTTCTAATCTTCT
TTTGATTGTCTTGTTAATTTTAGAAATTGTTGCCTTGATTGTCGCTCAGTTGATTGGTTATTTCATGGCTAATTACTTTA
TGAAACCATTGGAAAAACTTTATCAGGGCATGCAAGAAATGGCAAATGATCCAACAAATGATTTTGAACCGATTGAAATT
CAAAGTGGAGATGAAATCGAAGAGTTGGCTCATGTTTACAATGATATGATGTTGAAGATGAAGGCATATCTTGAACAGCA
AAATCGCTTTGTTTCTGATGTTTCTCATGAATTAAGAACACCTTTAGCTGTCTTGGATGGACATATTAACTTGTTGAATC
GATGGGGGAAAAATGATCCAGAAGTATTAGATGAATCTTTGCAGGCAAGTTTAGATGAAGTTGATCGAATGAAGAAAATG
CTTGAGGAGATGTTGGCTCTTGCTCGCCTTGAAAATGTTGACTTATCAAGTGAAGAACTGGATTGTGATGTTGGAAAAGT
TTGTAATCGGGCCCTTAAGAATTTTCAGCTTTTGCATGATGATTTTGAAATAGTGCTTGATAACCGGCTTATTTATCCCA
CTCATGCGCGAATTTCAGAAAATCATTTTGAACAAGGGTTACGAATTCTGTTAGATAATGCTGCTAAATACTCTCCTGAT
GATCGTAAAGAAATCGTGATTACTGTTTCTGAGGATGAACAGTTTGTGATTACGAGTGTATCTGACAAAGGAATTGGAAT
TTCAGAAGAAGATATTAATCATCTTTTTGAGCGTTTCTTTAGAGCGGACAAGGCTCGCAATCGAGAAATTGGTGGAACTG
GTTTAGGTTTATCAATTTTAGCTCGATTGGCAGAAAATTATCAAGGGGAAATTGAGGTAAATTCAGAACTGGGTCTTGGT
TCAACTTTTACACTAAAATTCCCGAAAATAAAATAA

Upstream 100 bases:

>100_bases
CGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATAGCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCG
TGAACGCAAATAAAAATAAG

Downstream 100 bases:

>100_bases
AGAATAAGAGAATTGCTAAAGGGCAGTTCTTTTTTTGCGACGTATGTTATGTTTTGTGACATCAAATGCAAAAATAATTG
ACTTGTTTAGAAAGTTGTGT

Product: sensor protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Sequences:

>Translated_491_residues
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK
>Mature_491_residues
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.5964125560538, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=27.6422764227642, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=28.3154121863799, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=29.7413793103448, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=287, Percent_Identity=28.9198606271777, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1787894, Length=303, Percent_Identity=27.0627062706271, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=26.431718061674, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=29.3103448275862, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790861, Length=290, Percent_Identity=27.9310344827586, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789403, Length=463, Percent_Identity=23.3261339092873, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788279, Length=283, Percent_Identity=24.7349823321555, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=27.0992366412214, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=30.316742081448, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994928, Length=228, Percent_Identity=27.6315789473684, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1789808, Length=241, Percent_Identity=24.4813278008299, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=28.2051282051282, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=26.9911504424779, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56196; Mature: 56196

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQ
CCCCCCCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTRSMDSVEEVLEKADAPLNSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEC
NHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKIISKSTGQVVGYLQAFYDTTTY
CCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
HRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCH
EVLDESLQASLDEVDRMKKMLEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHC
DFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPDDRKEIVITVSEDEQFVITSV
CHHEEECCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEEEC
SDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCC
STFTLKFPKIK
CEEEEECCCCC
>Mature Secondary Structure
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQ
CCCCCCCCCHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTRSMDSVEEVLEKADAPLNSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDL
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHCCCEEEEEEC
NHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKIISKSTGQVVGYLQAFYDTTTY
CCEEEEECCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
HRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCH
EVLDESLQASLDEVDRMKKMLEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHC
DFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPDDRKEIVITVSEDEQFVITSV
CHHEEECCEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCEEEEEEC
SDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCCC
STFTLKFPKIK
CEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA