Click here to switch to the map view.

The map label for this gene is ypjA

Identifier: 15673531

GI number: 15673531

Start: 1590528

End: 1591574

Strand: Reverse

Name: ypjA

Synonym: L190278

Alternate gene names: 15673531

Gene position: 1591574-1590528 (Counterclockwise)

Preceding gene: 15673532

Following gene: 15673530

Centisome position: 67.28

GC content: 41.93

Gene sequence:

>1047_bases
ATGAAATCAGTTTATTTTGTCGAAAAAAATAAAATGCAAGTTAGAGAATTTCCCAAAGCGCAACTTGTAAAAGAAACAGA
TGCTATCATAAAAATTGTTCGTGCCTGCGTATGTGGTTCCGATTTATGGTGGTTCCGTGGGATTTCTGAACGTCAACCTG
GACCGGTAGGGCATGAAGCTATTGGTCTGATTGAAGAAGTAGGCACCGGAGTTAAAAACTTTAAAGTAGGAGATTTTGTC
ATTGTTCCCTTTACGCACGGTTGTGGACACTGTCCAATTTGTTTGGCTGGCTTTGAAGCCAATTGTCCAAATGCAAAAGA
TGGTGTGAATGGCGGCTATCAAGGAGAATTCTATCGGGCGATTAATACTGATGGTGCACTTGTCAAAATCCCGGGCCAAC
CAAGTGATTATTCTGATGACCAGTTGGCTTCATTGACGGCTTTAGCTGATGTCATGCCTACAGGTTTTCATGCAGCTAAA
GCAGCAGATGTCCATGAAGGTGATACAGTGGTTGTCTTTGGTGATGGAGCGGTTGGACTTTGTGCAGTGATTTCAGCTAA
ACTTTTAGGAGCAAAACGGATTATTGCCATGAGTCGCCATGAAGACCGTGCAGCACTTGCGCGTGACTTTGGTGCAACAG
ATATTATTGATGAACGTGGTGAAGAAGCGATTCAAAAAATTATGTCCTTAACCAATGGTTATGGTGCAGATGCTGCCTTA
GAATGTGTCGGAACAAAACAAGCAATTGAATCTGCTTTTCAAGCGGTAAGAGCAGGAGGGCGAGTAGGTCGTGTGGGAGT
TCCTCATGATGTTGATTACAATGAATGGATTGATTCTCTTTTTTGGAAAAATATTCAACTTGGAGGGGGAGTAGCCTCTG
TCGCACGCTGGGATAAGGAAATCTTACTTGAAGCAGTTTTAAGTGGGGAGATTAATCCAGGCCGTGTCTTTACAGCAGAA
TTTAGCTTAGATGAAATTCAAAAAGCATATGAAGCAATGGATCAACGTACAGCAATTAAATCTCTATTGAGAATTTCAGA
GGTATAA

Upstream 100 bases:

>100_bases
TCCTTATGCTTTAAAAGCATAAGGAGTTTTTAAAAAAGTATTTTAAAAAAAGTAAAATTCATTTTATAATAAATTCAATA
AAAGAAAAGGAAGTAAAAAA

Downstream 100 bases:

>100_bases
ATAAGAAAATAGTAAATAAATCAAAAGTCTACCAAAGTTGGTGGGCTTTTTTGTATTCTAAAAGTCTTGTTTTTAAATTA
AGTTAAAACGGTTACTTTAT

Product: dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKSVYFVEKNKMQVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEAIGLIEEVGTGVKNFKVGDFV
IVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRAINTDGALVKIPGQPSDYSDDQLASLTALADVMPTGFHAAK
AADVHEGDTVVVFGDGAVGLCAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIDERGEEAIQKIMSLTNGYGADAAL
ECVGTKQAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKEILLEAVLSGEINPGRVFTAE
FSLDEIQKAYEAMDQRTAIKSLLRISEV

Sequences:

>Translated_348_residues
MKSVYFVEKNKMQVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEAIGLIEEVGTGVKNFKVGDFV
IVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRAINTDGALVKIPGQPSDYSDDQLASLTALADVMPTGFHAAK
AADVHEGDTVVVFGDGAVGLCAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIDERGEEAIQKIMSLTNGYGADAAL
ECVGTKQAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKEILLEAVLSGEINPGRVFTAE
FSLDEIQKAYEAMDQRTAIKSLLRISEV
>Mature_348_residues
MKSVYFVEKNKMQVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEAIGLIEEVGTGVKNFKVGDFV
IVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRAINTDGALVKIPGQPSDYSDDQLASLTALADVMPTGFHAAK
AADVHEGDTVVVFGDGAVGLCAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIDERGEEAIQKIMSLTNGYGADAAL
ECVGTKQAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKEILLEAVLSGEINPGRVFTAE
FSLDEIQKAYEAMDQRTAIKSLLRISEV

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=356, Percent_Identity=28.3707865168539, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI71565152, Length=366, Percent_Identity=28.4153005464481, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI4501933, Length=352, Percent_Identity=28.4090909090909, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262073058, Length=377, Percent_Identity=25.4641909814324, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI71743840, Length=377, Percent_Identity=25.4641909814324, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI156627571, Length=328, Percent_Identity=23.780487804878, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786825, Length=385, Percent_Identity=29.3506493506493, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1788073, Length=339, Percent_Identity=30.3834808259587, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790045, Length=328, Percent_Identity=29.8780487804878, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=28.8571428571429, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788075, Length=336, Percent_Identity=28.2738095238095, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=27.6881720430108, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1788407, Length=270, Percent_Identity=28.5185185185185, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081918, Length=273, Percent_Identity=32.2344322344322, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=23.3333333333333, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787863, Length=361, Percent_Identity=27.7008310249307, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510992, Length=335, Percent_Identity=25.3731343283582, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=350, Percent_Identity=26.5714285714286, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=362, Percent_Identity=25.6906077348066, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=362, Percent_Identity=25.414364640884, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=334, Percent_Identity=24.5508982035928, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17565904, Length=347, Percent_Identity=25.6484149855908, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17562584, Length=331, Percent_Identity=25.9818731117825, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=382, Percent_Identity=27.7486910994764, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6322619, Length=310, Percent_Identity=27.4193548387097, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=310, Percent_Identity=27.4193548387097, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=26.2536873156342, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=251, Percent_Identity=28.2868525896414, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=274, Percent_Identity=28.1021897810219, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=295, Percent_Identity=23.3898305084746, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=274, Percent_Identity=27.3722627737226, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=345, Percent_Identity=24.0579710144928, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=296, Percent_Identity=27.027027027027, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737895, Length=357, Percent_Identity=28.8515406162465, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137530, Length=343, Percent_Identity=26.2390670553936, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17737897, Length=358, Percent_Identity=24.0223463687151, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221457811, Length=325, Percent_Identity=24.3076923076923, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45551930, Length=325, Percent_Identity=24.3076923076923, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45550770, Length=325, Percent_Identity=24.3076923076923, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 37506; Mature: 37506

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVYFVEKNKMQVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEA
CCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHH
IGLIEEVGTGVKNFKVGDFVIVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRA
HHHHHHHCCCCCCEECCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
INTDGALVKIPGQPSDYSDDQLASLTALADVMPTGFHAAKAADVHEGDTVVVFGDGAVGL
ECCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEECCCHHHH
CAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIDERGEEAIQKIMSLTNGYGADAAL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ECVGTKQAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKE
HHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ILLEAVLSGEINPGRVFTAEFSLDEIQKAYEAMDQRTAIKSLLRISEV
HHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSVYFVEKNKMQVREFPKAQLVKETDAIIKIVRACVCGSDLWWFRGISERQPGPVGHEA
CCCEEEEECCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCHHH
IGLIEEVGTGVKNFKVGDFVIVPFTHGCGHCPICLAGFEANCPNAKDGVNGGYQGEFYRA
HHHHHHHCCCCCCEECCCEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEE
INTDGALVKIPGQPSDYSDDQLASLTALADVMPTGFHAAKAADVHEGDTVVVFGDGAVGL
ECCCCCEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHCCCCCCCCEEEEECCCHHHH
CAVISAKLLGAKRIIAMSRHEDRAALARDFGATDIIDERGEEAIQKIMSLTNGYGADAAL
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ECVGTKQAIESAFQAVRAGGRVGRVGVPHDVDYNEWIDSLFWKNIQLGGGVASVARWDKE
HHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
ILLEAVLSGEINPGRVFTAEFSLDEIQKAYEAMDQRTAIKSLLRISEV
HHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]